Now showing items 82-101 of 102

    • Quantification of cells expressing mesenchymal stem cell markers in healthy and osteoarthritic synovial membranes 

      Hermida Gómez, Tamara; Fuentes Boquete, Isaac Manuel; Gimeno-Longas, María José; Muiños-López, Emma; Díaz-Prado, Silvia; De-Toro, Javier; Blanco García, Francisco J (Journal of Rheumatology Publishing Company, 2010-11-15)
      [Abstract] Objective. To quantify cells expressing mesenchymal stem cell (MSC) markers in synovial mem- branes from human osteoarthritic (OA) and healthy joints. Methods. Synovial membranes from OA and healthy joints were ...
    • Reduced Levels of H₂S in Diabetes-Associated Osteoarthritis Are Linked to Hyperglycaemia, Nrf-2/HO-1 Signalling Downregulation and Chondrocyte Dysfunction 

      Piñeiro-Ramil, María; Burguera, Elena F.; Hermida-Gómez, Tamara; Caramés, Beatriz; Oreiro, Natividad; Meijide-Faílde, Rosa; Blanco García, Francisco J; Vaamonde-García, Carlos (MDPI, 2022-03-25)
      [Abstract] Different findings indicate that type 2 diabetes is an independent risk factor for osteoarthritis (OA). However, the mechanisms underlying the connection between both diseases remain unclear. Changes in the ...
    • Regulation of Angiogenesis Discriminates Tissue Resident MSCs from Effective and Defective Osteogenic Environments 

      Cuthbert, R.J.; Jones, Elena; Sanjurjo-Rodríguez, Clara; Lotfy, A.; Ganguly, P.; Churchman, S.M.; Kastana, P.; Tan, H.B.; McGonagle, Dennis; Papadimitriou, E.; Giannoudis, P.V. (MDPI, 2020-05-28)
      [Abstract] Background: The biological mechanisms that contribute to atrophic long bone non-union are poorly understood. Multipotential mesenchymal stromal cells (MSCs) are key contributors to bone formation and are ...
    • Risks factors of mechanical ventilation in acute traumatic cervical spinal cord injured patients 

      Montoto Marqués, Antonio; Trillo-Dono, Natalia; Ferreiro-Velasco, María Elena; Salvador de la Barrera, Sebastián; Rodríguez-Sotillo, Antonio; Mourelo-Fariña, Mónica; Galeiras, Rita; Meijide-Faílde, Rosa (Springer, 2017-10-23)
      [Abstract] Study design: Descriptive retrospective study. Objectives: To analyze risk factors associated with mechanical ventilation (MV) in cases of acute traumatic Cervical Spinal Cord Injury (tCSCI). Setting: ...
    • Risks factors of mechanical ventilation in acute traumatic cervical spinal cord injured patients 

      Montoto-Marqués, A.; Trillo-Dono, Natalia; Ferreiro-Velasco, M.E.; Salvador-de-la-Barrera, S.; Rodríguez-Sotillo, A.; Mourelo-Fariña, Mónica; Galeiras, Rita; Meijide-Faílde, Rosa (Nature, 2017-10-23)
      [Abstract] Study design. Descriptive retrospective study. Objectives. To analyze risk factors associated with mechanical ventilation (MV) in cases of acute traumatic Cervical Spinal Cord Injury (tCSCI). Setting. Unidad ...
    • Small Extracellular Vesicles Have GST Activity and Ameliorate Senescence-Related Tissue Damage 

      Fafián Labora, Juan Antonio; Rodríguez-Navarro, José Antonio; O’Loghlen, Ana (Elsevier, 2020-07-07)
      [Abstract] Aging is a process of cellular and tissue dysfunction characterized by different hallmarks, including cellular senescence. However, there is proof that certain features of aging and senescence can be ameliorated. ...
    • Spanish Rheumatology Society and Hospital Pharmacy Society Consensus on recommendations for biologics optimization in patients with rheumatoid arthritis, ankylosing spondylitis and psoriatic arthritis 

      González-Álvaro, Isidoro; Martínez-Fernández, Carmen; Dorantes-Calderón, Benito; García-Vicuña, Rosario; Hernández-Cruz, Blanca; Herrero-Ambrosio, Alicia; Ibarra-Barrueta, Olatz; Martín-Mola, Emilio; Monte-Boquet, Emilio; Morell-Baladrón, Alberto; Sanmartí, Raimon; Sanz-Sanz, Jesús; De-Toro, Javier; Vela, Paloma; Román Ivorra, José Andrés; Poveda-Andrés, José Luis; Muñoz-Fernández, Santiago (Oxford University Press, 2014-12-19)
      [Abstract] Objective. The aim of this study was to establish guidelines for the optimization of biologic therapies for health professionals involved in the management of patients with RA, AS and PsA. Methods. Recommendations ...
    • Statistical degradation modelling of Poly(D,L-lactide-co-glycolide) copolymers for bioscaffold applications 

      Robles-Bykbaev, Yaroslava; Tarrío-Saavedra, Javier; Quintana-Pita, Sara; Díaz-Prado, Silvia; García Sabán, Francisco Javier; Naya, Salvador (PLOS, 2018-10-01)
      [Abstract] This methodology permits to simulate the performance of different Poly(D,L-lactide-co-glycolide) copolymer formulations (PDLGA) in the human body, to identify the more influencing variables on hydrolytic degradation ...
    • The addition of albumin improves Schwann cells viability in nerve cryopreservation 

      González Porto, Sara Alicia; Doménech, Nieves; González Rodríguez, Alba; Avellaneda Oviedo, Edgar Mauricio; Blanco García, Francisco J; Arufe, M.C.; Álvarez Jorge, Ángel; Sánchez Ibáñez, Jacinto; Rendal Vázquez, María Esther (Springer, 2018-04-26)
      [Abstract] The purpose of the current study was to establish a valid protocol for nerve cryopreservation, and to evaluate if the addition of albumin supposed any advantage in the procedure. We compared a traditional ...
    • The experience of inflammatory bowel disease patients with healthcare: a survey with the IEXPAC instrument 

      Marín-Jiménez, Ignacio; Casellas, Francesc; Cortés, Xavier; García-Sepulcre, Mariana; Juliá, Berta; Cea-Calvo, Luis; Soto, Nadia; Navarro-Correal, Ester; Saldaña, Roberto; De-Toro, Javier; Galindo, María J.; Orozco-Beltrán, Domingo (Wolters Kluwer, 2019-04)
      [Abstract] To assess inflammatory bowel disease (IBD) patients' experience of chronic illness care and the relationship with demographic and healthcare-related characteristics.This cross-sectional survey used the Instrument ...
    • The Experience With Health Care of Patients With Inflammatory Arthritis: A Cross-sectional Survey Using the Instrument to Evaluate the Experience of Patients With Chronic Diseases 

      De-Toro, Javier; Cea-Calvo, Luis; García-Vivar, María L.; Pantoja, Lucía; Lerín-Lozano, Cristina; García-Díaz, Silvia; Galindo, María J.; Marín-Jiménez, Ignacio; Fernández, Sabela; Mestre, Yvonne; Orozco-Beltrán, Domingo (Wolters Kluwer, 2021-01-27)
      [Abstract] Background: Patients' experience with health care is becoming a key component for the provision of a patient-centered health care model. The aim of this study was to assess the experience with health care of ...
    • The Influence of Patient Experience with Healthcare on the Health-Related Quality of Life of People Living with HIV: An Observational Cross-Sectional Survey 

      Fuster-RuizdeApodaca, María J.; Sánchez-Vega, Nuria; Galindo, María J.; Marín-Jimenez, Ignacio; De-Toro, Javier; Orozco-Beltrán, Domingo; Cotarelo, Manuel; López, Juan Carlos (Springer Nature, 2019-07-09)
      [Abstract] Introduction Patient experience is central to the quality of healthcare delivery, showing positive associations with several outcome measures. The main objectives of this study are to analyze the influence of ...
    • The mitochondrial inhibitor oligomycin induces an inflammatory response in the rat knee joint 

      Vaamonde-García, Carlos; Loureiro, Jesús; Valcárcel Ares, Marta Noa; Riveiro Naveira, Romina R.; Ramil-Gómez, Olalla; Hermida-Carballo, Laura; Centeno, Alberto; Meijide-Faílde, Rosa; Blanco García, Francisco J; López-Armada, María José (BioMed Central, 2017-06-12)
      [Abstract] Background. Recent findings support a connection between mitochondrial dysfunction and activation of inflammatory pathways in articular cells. This study investigates in vivo in an acute model whether ...
    • The teaching of rheumatology at the university: the journey from teacher based to student-centered learning 

      Naranjo, Antonio; de-Toro, Javier; Nolla, Joan M. (Elsevier, 2015-07)
      [Abstract] In recent years, university education has undergone profound changes as a result of the creation of the European Space for Higher Education. It has gone from a teacher-centred model, based on the transmission ...
    • The use of antidotes for calcium gluconate extravasation: an experimental study in mice 

      Pacheco Compaña, Francisco Javier; Midón Míguez, José; De-Toro, Javier; Centeno, Alberto; López San Martín, Patricia; Yebra-Pimentel Vidal, María Teresa; Mosquera Osés, Joaquín José (Wolters Kluwer, 2018)
      [Abstract] Background: Calcium gluconate extravasation is a process that can cause serious lesions, such as necrosis and calcification of the soft tissues. The aim of the present study was to analyze the beneficial effects ...
    • Tips and Tricks for Successfully Culturing and Adapting Human Induced Pluripotent Stem Cells [Protocol] 

      Castro Viñuelas, Rocío; Sanjurjo-Rodríguez, Clara; Piñeiro-Ramil, María; Rodríguez-Fernández, Silvia; López-Baltar, Isidoro; Fuentes Boquete, Isaac Manuel; Blanco García, Francisco J; Díaz-Prado, Silvia (Cell Press, 2021-12)
      [Abstract] Reprogramming somatic cells toward pluripotency became possible over a decade ago. Since then, induced pluripotent stem cells (iPSCs) have served as a versatile and powerful tool not only for basic research but ...
    • Tissue array analysis for the differentiation of gliosis from gliomas 

      Medina Villaamil, Vanessa; Álvarez García, A.; Aparicio Gallego, Guadalupe; Díaz-Prado, Silvia; Rivas López, A.; Santamarina, Isabel; Valladares-Ayerbes, Manuel; Antón-Aparicio, Luis M. (Spandidos, 2011-03-22)
      [Abstract] The aim of this study was to provide a methodology to make a clear distinction between malignant tumors and morphologically similar benign processes, by examining the expression of EGFR, VEGF, HIF1-α, survivin, ...
    • Umbilical Cord as a Mesenchymal Stem Cell Source for Treating Joint Pathologies 

      Arufe, M.C.; Fuente, Alexandre de la; Fuentes Boquete, Isaac Manuel; De-Toro, Javier; Blanco García, Francisco J (Baishideng, 2011-06-18)
      [Abstract] Articular cartilage disorders and injuries often result in life-long chronic pain and compromised quality of life. Regrettably, the regeneration of articular cartilage is a continuing challenge for biomedical ...
    • Usefulness of mesenchymal cell lines for bone and cartilage regeneration research 

      Piñeiro-Ramil, María; Sanjurjo-Rodríguez, Clara; Castro Viñuelas, Rocío; Rodríguez-Fernández, Silvia; Fuentes Boquete, Isaac Manuel; Blanco García, Francisco J; Díaz-Prado, Silvia (MDPI, 2019-12-13)
      [Abstract] The unavailability of sufficient numbers of human primary cells is a major roadblock for in vitro repair of bone and/or cartilage, and for performing disease modelling experiments. Immortalized mesenchymal ...
    • Versatility of induced Pluripotent Stem Cells (iPSCs) for improving the knowledge on musculoskeletal diseases 

      Sanjurjo-Rodríguez, Clara; Castro Viñuelas, Rocío; Piñeiro-Ramil, María; Rodríguez-Fernández, Silvia; Fuentes Boquete, Isaac Manuel; Blanco García, Francisco J; Díaz-Prado, Silvia (MDPI, 2020-08-25)
      [Abstract] Induced pluripotent stem cells (iPSCs) represent an unlimited source of pluripotent cells capable of di erentiating into any cell type of the body. Several studies have demonstrated the valuable use of iPSCs ...