Listar INIBIC-TCMR - Artigos por título
Mostrando ítems 64-83 de 102
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Lamin A deregulation in human mesenchymal stem cells promotes an impairment in their chondrogenic potential and imbalance in their response to oxidative stress
(Elsevier, 2013-07-26)[Abstract] In the present study, we examined the effect of the over-expression of LMNA, or its mutant form progerin (PG), on the mesoderm differentiation potential of mesenchymal stem cells (MSCs) from human umbilical cord ... -
Long-term effects of hydrogen sulfide on the anabolic-catabolic balance of articular cartilage in vitro
(Elsevier, 2017-08-15)[Abstract] Healthy cartilage maintenance relies on an equilibrium among the anabolic and catabolic processes in chondrocytes. With the onset of osteoarthritis (OA), increased interleukin (IL)-1β levels induce an inhibition ... -
Mesenchymal stem cell functionalization for enhanced therapeutic applications
(Mary Ann Liebert, 2019-02-14)[Abstract] Culture expansion of MSCs has detrimental effects on various cell characteristics and attributes (e.g., phenotypic changes and senescence), which, in addition to inherent interdonor variability, negatively impact ... -
Mesenchymal stromal cells for articular cartilage repair: preclinical studies
(AO Research Institute Davos (ARI), 2020-08-26)[Abstract] Rheumatic diseases such as osteoarthritis (OA) are a major social and economic burden because of the population aging and the lack of curative solutions. An effective cell therapy may be the best treatment ... -
Molecular profile and cellular characterization of human bone marrow mesenchymal stem cells: donor influence on chondrogenesis
(Elsevier, 2010)[Abstract] Background. The use of autologous or allogenic stem cells has recently been suggested as an alternative therapeutic approach for treatment of cartilage defects. Bone marrow mesenchymal stem cells (BM-MSCs) are ... -
Multilineage differentiation potential of cells isolated from the human amniotic membrane
(Wiley, 2010-11-01)[Abstract] The human amniotic membrane (HAM) contains two cell types from different embryological origins. Human amnion epithelial cells (hAECs) are derived from the embryonic ectoderm, while human amnion mesenchymal stromal ... -
Myofascial release therapy in the treatment of occupational mechanical neck pain: a randomized parallel group study
(Wolters Kluwer, 2016-07)[Abstract] Objective: As myofascial release therapy is currently under development, the objective of this study was to compare the effectiveness of myofascial release therapy with manual therapy for treating occupational ... -
Next-generation sequencing and quantitative proteomics of Hutchinson-Gilford progeria syndrome-derived cells point to a role of nucleotide metabolism in premature aging
(PLOS, 2018-10-31)[Abstract] Hutchinson-Gilford progeria syndrome (HGPS) is a very rare fatal disease characterized for accelerated aging. Although the causal agent, a point mutation in LMNA gene, was identified more than a decade ago, the ... -
NF-κB/IKK Activation by Small Extracellular Vesicles Within the SASP
(Wiley, 2021-06-29)[Abstract] Cellular senescence plays an important role in different biological and pathological conditions. Senescent cells communicate with their microenvironment through a plethora of soluble factors, metalloproteases ... -
Notch signalling in cancer stem cells
(Springer, 2009)[Abstract] A new theory about the development of solid tumours is emerging from the idea that solid tumours, like normal adult tissues, contain stem cells (called cancer stem cells) and arise from them. Genetic mutations ... -
Organisational and clinical approach to osteoporosis in rheumatology: OP-SER-Excellence survey and consensus
(Elsevier, 2021-05-07)[Abstract] Objective. To determine and analyse the organisational approach adopted by Spanish rheumatologists to osteoporosis (OP) to define strategic priorities. Material and method. A group of experts designed a ... -
Ovine mesenchymal stromal cells: morphologic, phenotypic and functional characterization for osteochondral tissue engineering
(PLoS ONE, 2017-01-31)[Abstract] Introduction. Knowledge of ovine mesenchymal stromal cells (oMSCs) is currently expanding. Tissue engineering combining scaffolding with oMSCs provides promising therapies for the treatment of osteochondral ... -
Patients' perceptions on shared decision making during prescription of subcutaneous biological drug treatments for inflammatory arthritis: the RHEU-LIFE survey
(Wiley, 2020-08-24)[Abstract] Objectives: The aim of this study was to explore the preferences of patients with rheumatic diseases and their perceived experience regarding participation in shared decision making (SDM) when they were prescribed ... -
Perceptions of patients with rheumatic diseases treated with subcutaneous biologicals on their level of information: RHEU-LIFE survey
(Elsevier, 2018-12-21)[Abstract] Objective: To investigate, in Spanish patients with rheumatic diseases treated with subcutaneous biological drugs, their sources of information, which sources they consider most relevant, and their satisfaction ... -
Potential use of the human amniotic membrane as a scaffold in human articular cartilage repair
(Springer, 2010-04-13)[Abstract] The human amniotic membrane (HAM) is an abundant and readily obtained tissue that may be an important source of scaffold for transplanted chondrocytes in cartilage regeneration in vivo. To evaluate the potential ... -
Prevalencia de osteoporosis, estimación de la probabilidad de fractura y estudio del metabolismo óseo en pacientes con reciente diagnóstico de cáncer de próstata en el área sanitaria de Lugo
(Elsevier, 2017-06-17)[Resumen] Objetivo. Estudiar la prevalencia de osteoporosis y probabilidad de fractura en pacientes diagnosticados de cáncer de próstata. Diseño. Estudio observacional, descriptivo y transversal. Emplazamiento. ... -
Proteome Analysis During Chondrocyte Differentiation in a New Chondrogenesis Model Using Human Umbilical Cord Stroma Mesenchymal Stem Cells
(American Society for Biochemistry and Molecular Biology, 2011-10-17)[Abstract] Umbilical cord stroma mesenchymal stem cells were differentiated toward chondrocyte-like cells using a new in vitro model that consists of the random formation of spheroids in a medium supplemented with fetal ... -
Proteomic applications in the study of human mesenchymal stem cells
(Multidisciplinary Digital Publishing Institute, 2014-02-07)Mesenchymal stem cells (MSCs) are undifferentiated cells with an unlimited capacity for self-renewal and able to differentiate towards specific lineages under appropriate conditions. MSCs are, a priori, a good target for ... -
Quantification of cells expressing mesenchymal stem cell markers in healthy and osteoarthritic synovial membranes
(Journal of Rheumatology Publishing Company, 2010-11-15)[Abstract] Objective. To quantify cells expressing mesenchymal stem cell (MSC) markers in synovial mem- branes from human osteoarthritic (OA) and healthy joints. Methods. Synovial membranes from OA and healthy joints were ... -
Reduced levels of H₂S in diabetes-associated osteoarthritis are linked to hyperglycaemia, Nrf-2/HO-1 signalling downregulation and chondrocyte dysfunction
(MDPI, 2022-03-25)[Abstract] Different findings indicate that type 2 diabetes is an independent risk factor for osteoarthritis (OA). However, the mechanisms underlying the connection between both diseases remain unclear. Changes in the ...