Now showing items 1-20 of 113

    • 3, 3′, 5-triiodo-L-thyronine increases in vitro chondrogenesis of mesenchymal stem cells from human umbilical cord stroma through SRC2 

      Fernández-Pernas, Pablo; Fafián Labora, Juan Antonio; Lesende-Rodríguez, Iván; Mateos, Jesús; Fuente, Alexandre de la; Fuentes Boquete, Isaac Manuel; De-Toro, Javier; Blanco García, Francisco J; Arufe, M.C. (Wiley, 2016-07-08)
      [Abstract] Our group focuses on the study of mesenchymal stem cells (MSCs) from human umbilical cord stroma or Warthońs jelly and their directed differentiation toward chondrocyte-like cells capable of regenerating damaged ...
    • A Comparative Study of Doppler Ultrasound Against Temporal Artery Biopsy in the Diagnosis of Giant Cell Arteritis 

      González Porto, Sara Alicia; Silva-Díaz, María T.; Reguera Arias, Ana; Pombo-Otero, Jorge; González Rodríguez, Alba; Valero Gasalla, Javier; De-Toro, Javier (Elsevier, 2020-08-13)
      [Abstract] Background. Giant cell arteritis (GCA) is a vasculitis that affects medium- and large-sized arteries. Temporal artery biopsy is the gold standard for diagnosis. In view of the high demand for temporal biopsies, ...
    • A survey of anatomical items relevant to the practice of rheumatology: pelvis, lower extremity, and gait 

      Hernández-Díaz, Cristina; Álvarez-Nemegyei, José; Navarro-Zarza, José Eduardo; Villaseñor-Ovies, Pablo; Kalish, Robert A.; Canoso, Juan J.; Vargas, Angélica; Chiapas-Gasca, Karla; Biundo, Joseph J.; De-Toro, Javier; McGonagle, Dennis; Carette, Simon; Saavedra, Miguel Ángel (Springer, 2017-06-01)
      [Abstract] This study aimed to generate a minimum list of structural and functional anatomical items about the pelvis/hip, knee, ankle/foot, gait, and lower limb innervation, which are most relevant to the practice of ...
    • A survey of anatomical items relevant to the practice of rheumatology: upper extremity, head, neck, spine, and general concepts 

      Villaseñor-Ovies, Pablo; Navarro-Zarza, José Eduardo; Saavedra, Miguel Ángel; Hernández-Díaz, Cristina; Canoso, Juan J.; Biundo, Joseph J.; Kalish, Robert A.; De-Toro, Javier; McGonagle, Dennis; Carette, Simon; Álvarez-Nemegyei, José (Springer, 2016-08-18)
      [Abstract] This study aimed to identify the anatomical items of the upper extremity and spine that are potentially relevant to the practice of rheumatology. Ten rheumatologists interested in clinical anatomy who published, ...
    • Adherence to synthetic disease-modifying antirheumatic drugs in rheumatoid arthritis: results of the OBSERVAR study 

      Juan Mas, Antonio; Castañeda, Santos; Cantero Santamaría, José I.; Baquero, José L.; De-Toro, Javier (Elsevier, 2019-01-10)
      [Abstract] Background: Treatment compliance with disease-modifying antirheumatic drugs (DMARD) is essential to achieve the therapeutic goals in rheumatoid arthritis (RA). However, despite the need for good compliance, there ...
    • Alternative protocols to induce chondrogenic differentiation: transforming growth factor-β superfamily 

      Cicione, Claudia; Muiños Gómez, Emma; Hermida Gómez, Tamara; Fuentes Boquete, Isaac Manuel; Díaz-Prado, Silvia; Blanco García, Francisco J (Springer, 2014-09-10)
      [Abstract] Mesenchymal stem cells (MSCs) are an accepted candidate for cell-based therapy of multiple diseases. The interest in MSCs and their possible application in cell therapy have resulted in a better understanding ...
    • An artificial-vision- and statistical-learning-based method for studying the biodegradation of type I collagen scaffolds in bone regeneration systems 

      Robles-Bykbaev, Yaroslava; Naya, Salvador; Díaz-Prado, Silvia; Calle-López, D.; Robles-Bykbaev, Vladimir; Garzón, Luis; Sanjurjo-Rodríguez, Clara; Tarrío-Saavedra, Javier (PeerJ, 2019-07-05)
      [Abstract] This work proposes a method based on image analysis and machine and statistical learning to model and estimate osteocyte growth (in type I collagen scaffolds for bone regeneration systems) and the collagen ...
    • Analysis of Cryopreservation Protocols and Their Harmful Effects on the Endothelial Integrity of Human Corneas 

      Rodríguez-Fernández, Silvia; Álvarez-Portela, Marcelino; Rendal Vázquez, María Esther; Piñeiro-Ramil, María; Sanjurjo-Rodríguez, Clara; Castro Viñuelas, Rocío; Sánchez-Ibáñez, Jacinto; Fuentes Boquete, Isaac Manuel; Díaz-Prado, Silvia (MDPI, 2021-11-22)
      [Abstract] Corneal cryopreservation can partially solve the worldwide concern regarding donor cornea shortage for keratoplasties. In this study, human corneas were cryopreserved using two standard cryopreservation protocols ...
    • Analysis of the Chondrogenic Potential and Secretome of Mesenchymal Stem Cells Derived from Human Umbilical Cord Stroma 

      Arufe, M.C.; Fuente, Alexandre de la; Mateos, Jesús; Fuentes Boquete, Isaac Manuel; De-Toro, Javier; Blanco García, Francisco J (Mary Ann Liebert, 2011-06-28)
      [Abstract] Mesenchymal stem cells (MSCs) from umbilical cord stroma were isolated by plastic adherence and characterized by flow cytometry, looking for cells positive for OCT3/4 and SSEA-4 as well as the classic MSC markers ...
    • Association between non-adherence behaviors, patients’ experience with healthcare and beliefs in medications: a survey of patients with different chronic conditions 

      Cea-Calvo, Luis; Marín-Jiménez, Ignacio; De-Toro, Javier; Fuster-RuizdeApodaca, María J.; Fernández, Gonzalo; Sánchez-Vega, Nuria; Orozco-Beltrán, Domingo (Taylor & Francis, 2019-10-15)
      [Abstract] Objective: The objective of the current work was to assess the frequency of non-adherence behaviors and potential association with patients' experience with healthcare and beliefs in medicines self-reported by ...
    • Biodistribution and Immunogenicity of Allogeneic Mesenchymal Stem Cells in a Rat Model of Intraarticular Chondrocyte Xenotransplantation 

      Marquina, Maribel; Collado, Javier A.; Pérez-Cruz, Magdiel; Fernández-Pernas, Pablo; Fafián Labora, Juan Antonio; Blanco García, Francisco J; Máñez, Rafael; Arufe, M.C.; Costa, Cristina (Frontiers, 2017-11-06)
      [Abstract] Xenogeneic chondrocytes and allogeneic mesenchymal stem cells (MSC) are considered a potential source of cells for articular cartilage repair. We here assessed the immune response triggered by xenogeneic ...
    • Biology of BMP signalling and cancer 

      Blanco, Moisés; Bolós Fernández, Victoria; Medina Villaamil, Vanessa; Aparicio Gallego, Guadalupe; Díaz-Prado, Silvia; Grande Pulido, Enrique (Springer, 2009)
      [Abstract] In recent years, it has been proposed that tumours are not homogeneous but composed of several cellular types like normal tissues. A cellular subtype, which is though to be the origin of tumours as well as their ...
    • Blood RNA sequencing reveals immunological processes associated with the response to abatacept in rheumatoid arthritis. 

      Julià, Antonio; López Lasanta, María; Gómez, Antonio; Sanmartí, Raimon; Marras, Carlos; Pina Salvador, José Manuel; Romero Yuste, Susana; Veiga Cabello, Raúl María; Navarro, Pilar; Moragues Pastor, Carme; Martínez Pardo, Silvia; De-Toro, Javier; Sánchez, Amalia; Cerda, Dacia; Prada, Alejandro; Erra, Alba; Monfort, Jordi; Urruticoechea-Arana, Ana; Palau, Núria; Lastra, Raquel M.; Tortosa, Raúl; Pluma Sanjurjo, Andrea; Marsal, Sara (BMJ Journals, 2019-05-27)
    • Bone marrow cells immunomagnetically selected for CD271+ antigen promote in vitro the repair of articular cartilage defects 

      Hermida Gómez, Tamara; Fuentes Boquete, Isaac Manuel; Gimeno-Longas, María José; Muíños-López, Emma; Díaz-Prado, Silvia; De-Toro, Javier; Blanco García, Francisco J (Mary Ann Liebert, 2011-03-22)
      [Abstract] Objective: The purposes of this project were to quantify the cells expressing the mesenchymal stem cell (MSC) marker CD271 in synovial membranes from human osteoarthritic (OA) and healthy joints, and to determine ...
    • Cartilage tissue engineering: adult human mesenchymal stromal cells and collagen biomaterials 

      Sanjurjo-Rodríguez, Clara; Martínez Sánchez, A.H.; Hermida Gómez, Tamara; Fuentes Boquete, Isaac Manuel; Buján, J.; De-Toro, Javier; Díaz-Prado, Silvia; Blanco García, Francisco J (Elsevier, 2014-03-20)
    • CD105+-Mesenchymal Stem Cells Migrate into Osteoarthritis Joint: an Animal Model 

      Fernández-Pernas, Pablo; Rodríguez-Lesende, Iván; Fuente, Alexandre de la; Mateos, Jesús; Fuentes Boquete, Isaac Manuel; De-Toro, Javier; Blanco García, Francisco J; Arufe, M.C. (PLoS, 2017-11-30)
      [Abstract] Mesenchymal stem cells are being the focus of connective tissue technology and regenerative medicine, presenting a good choice cell source for improving old and well recognized techniques of cartilage defect ...
    • Cell and Tissue Transplant Strategies for Joint Lesions 

      Fuentes Boquete, Isaac Manuel; Arufe, M.C.; Díaz-Prado, Silvia; Hermida Gómez, Tamara; De-Toro, Javier; Blanco García, Francisco J (Bentham Open, 2008-07-11)
      [Abstract] Articular cartilage lesions that do not disrupt the integrity of subchondral bone are not capable of spontaneous repair. The asymptomatic nature of these lesions leads to articular cartilage degeneration and ...
    • Cell therapy and tissue engineering for cartilage repair 

      Piñeiro-Ramil, María; Castro Viñuelas, Rocío; Sanjurjo-Rodríguez, Clara; Hermida Gómez, Tamara; Fuentes Boquete, Isaac Manuel; De-Toro, Javier; Blanco García, Francisco J; Díaz-Prado, Silvia (IntechOpen, 2018-02-14)
      [Abstract] The integrity of the articular cartilage is necessary for the proper functioning of the diarthrodial joint. The self-repair capacity of this tissue is very limited and, currently, there is no effective treatment ...
    • Cell viability assay in corneal endothelium 

      Rodríguez-Fernández, Silvia; Álvarez Portela, Marcelino; Rendal Vázquez, María Esther; Montero Salinas, Alejandro; Piñeiro-Ramil, María; Castro Viñuelas, Rocío; Rojas, María Victoria de; Sánchez Ibáñez, Jacinto; Fuentes Boquete, Isaac Manuel; Díaz-Prado, Silvia (2018)
      [Abstract] Introduction: Endothelium is the inner layer of the cornea, which must be viable for transplanting. The limited availability of corneas makes necessary the developing of preservation ...
    • Characterization of microRNA expression profiles in normal and osteoarthritic human chondrocytes 

      Díaz-Prado, Silvia; Cicione, Claudia; Muiños-López, Emma; Hermida Gómez, Tamara; Oreiro, Natividad; Fernández-López, Carlos; Blanco García, Francisco J (BioMed Central, 2012-08-12)
      [Abstract] Background. Osteoarthritis (OA) is a multifactorial disease characterized by destruction of the articular cartilage due to environmental, mechanical and genetic components. The genetics of OA is complex and ...