Listar Terapia Celular e Medicina Rexenerativa por título

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    • Gene expression and functional comparison between multipotential stromal cells from lateral and medial condyles of knee osteoarthritis patients 

      Sanjurjo-Rodríguez, Clara; Baboolal, Thomas G.; Burska, Agata N.; Ponchel, Frederique; El-Jawhari, Jehan J.; Pandit, Hemant; McGonagle, Dennis; Jones, Elena (Nature Publishing Group, 2019-06-29)
      [Abstract] Osteoarthritis (OA) is the most common degenerative joint disorder. Multipotential stromal cells (MSCs) have a crucial role in joint repair, but how OA severity affects their characteristics remains unknown. ...

    • Gene Expression Signatures of Synovial Fluid Multipotent Stromal Cells in Advanced Knee Osteoarthritis and Following Knee Joint Distraction 

      Sanjurjo-Rodríguez, Clara; Altaie, Ala; Mastbergen, Simon; Baboolal, Thomas G.; Welting, Tim; Lafeber, Floris; Pandit, Hemant; McGonagle, Dennis; Jones, Elena (Frontiers Media S.A., 2020-10-14)
      [Abstract] Osteoarthritis (OA) is the most common musculoskeletal disorder. Although joint replacement remains the standard of care for knee OA patients, knee joint distraction (KJD), which works by temporarily off-loading ...

    • Generation and Characterization of Human Induced Pluripotent Stem Cells (iPSCs) From Hand Osteoarthritis Patient-Derived Fibroblasts 

      Castro Viñuelas, Rocío; Sanjurjo-Rodríguez, Clara; Piñeiro-Ramil, María; Hermida Gómez, Tamara; Rodríguez-Fernández, Silvia; Oreiro, Natividad; De-Toro, Javier; Fuentes Boquete, Isaac Manuel; Blanco García, Francisco J; Díaz-Prado, Silvia (Nature Research, 2020-03-06)
      [Abstract] Knowledge and research results about hand osteoarthritis (hOA) are limited due to the lack of samples and animal models of the disease. Here, we report the generation of two induced pluripotent stem cell ...

    • Generation of a human control iPS cell line (ESi080‐A) from a donor with no rheumatic diseases 

      Castro Viñuelas, Rocío; Sanjurjo-Rodríguez, Clara; Piñeiro-Ramil, María; Rodríguez-Fernández, Silvia; Fuentes Boquete, Isaac Manuel; Blanco García, Francisco J; Díaz-Prado, Silvia (Elsevier, 2020-03)
      [Abstract] Here, we report the establishment of the human iPS cell line N1-FiPS4F#7 generated from skin cells of a patient with no rheumatic diseases, thus obtaining an appropriate control iPS cell line for researchers ...

    • Generation of Mesenchymal Cell Lines Derived from Aged Donors 

      Piñeiro-Ramil, María; Sanjurjo-Rodríguez, Clara; Rodríguez-Fernández, Silvia; Castro Viñuelas, Rocío; Hermida Gómez, Tamara; Blanco García, Francisco J; Fuentes Boquete, Isaac Manuel; Díaz-Prado, Silvia (MDPI, 2021-10-01)
      [Abstract] Background: Mesenchymal stromal cells (MSCs) have the capacity for self-renewal and multi-differentiation, and for this reason they are considered a potential cellular source in regenerative medicine of cartilage ...

    • Generation of osteoarthritic mesenchymal stromal cell lines. 

      Piñeiro-Ramil, María; Castro Viñuelas, Rocío; Sanjurjo-Rodríguez, Clara; Rodríguez-Fernández, Silvia; Hermida Gómez, Tamara; De-Toro, Javier; Blanco García, Francisco J; Fuentes Boquete, Isaac Manuel; Díaz-Prado, Silvia (BMJ Journals, 2019-05-27)

    • Generation of osteoarthritis and healthy mesenchymal cell lines for research on regenerative medicine for osteoarthritis 

      Piñeiro-Ramil, María; Castro Viñuelas, Rocío; Sanjurjo-Rodríguez, Clara; Hermida Gómez, Tamara; Fuentes Boquete, Isaac Manuel; De-Toro, Javier; Blanco García, Francisco J; Díaz-Prado, Silvia (2018-04)
      [Purpose] Bone-marrow mesenchymal stem cells (BM-MSCs) are multipotent self-renewal adult cells with potential to regenerate the damaged tissues in degenerative diseases such as osteoarthritis (OA). Nevertheless, research ...

    • Genome Wide CRISPR/Cas9 Screen Identifies the Coagulation Factor IX (F9) as a Regulator of Senescence 

      Carpintero-Fernández, Paula; Borghesan, Michela; Eleftheriadou, Olga; Pan-Castillo, Belén; Fafián Labora, Juan Antonio; Mitchell, Tom P.; Yuste, Alejandro; Ogrunc, Muge; Nightingale, Thomas D.; Mayán, María; O'Loghlen, Ana (Nature, 2022-02-19)
      [Abstract] During this last decade, the development of prosenescence therapies has become an attractive strategy as cellular senescence acts as a barrier against tumour progression. In this context, CDK4/6 inhibitors induce ...

    • Global DNA Methylation in Dental Implant Failure Due to Peri-Implantitis: An Exploratory Clinical Pilot Study 

      Khouly, Ismael; Pardiñas López, Simón; Díaz-Prado, Silvia; Ferrantino, Luca; Kalm, Josephine; Larsson, Lena; Asa'ad, Farah (MDPI, 2022-01-17)
      [Abstract] Background: Peri-implantitis (PIT) is highly prevalent in patients with dental implants and is a challenging condition to treat due to the limited outcomes reported for non-surgical and surgical therapies. ...

    • Healthcare experience among patients with type 2 diabetes: A cross-sectional survey using the IEXPAC tool 

      Orozco-Beltrán, Domingo; Artola-Menéndez, Sara; Hormigo-Pozo, Antonio; Cararach-Salami, Daniel; Alonso-Jerez, José Luis; Álvaro-Grande, Epifanio; Villalibre-Arias, Covadonga; De-Toro, Javier; Galindo-Puerto, María José; Marín-Jiménez, Ignacio; Gómez-García, Antón; Ledesma-Rodríguez, Rocío; Fernández, Gonzalo; Ferreira de Campos, Karine (Wiley, 2021-02-15)
      [Abstract] Aim: To assess the experience with health care among patients with type 2 diabetes (T2DM) and to evaluate patients' demographic variables and healthcare-related characteristics which may affect their ...

    • Healthcare experience and their relationship with demographic, disease and healthcare-related variables: a cross-sectional survey of patients with chronic diseases using the IEXPAC scale. 

      Orozco-Beltrán, Domingo; De-Toro, Javier; Galindo, María J.; Marín-Jiménez, Ignacio; Casellas, Francesc; Fuster-RuizdeApodaca, María J.; García-Vivar, María L.; Hormigo-Pozo, Antonio; Guilabert, Mercedes; Sánchez-Vega, Nuria; Fernández, Gonzalo; Cea-Calvo, Luis (Springer, 2018-11-15)
      [Abstract] BACKGROUND: Patient experience is acknowledged as a principal aspect of quality healthcare delivery, and it has implications with regard to outcomes. OBJECTIVES: Our objective was to evaluate the healthcare ...

    • Hedgehog signalling as a target in cancer stem cells 

      Medina Villaamil, Vanessa; Blanco, Moisés; Díaz-Prado, Silvia; Espada, Jesús (Spirnger, 2009)
      [Abstract] Hedgehog (Hh) is one of the most important signalling pathways. Together with the Wnt, TGF-β/BMP and Notch pathways, it is involved in both embryonic development and adult tissue homeostasis. This is because Hh ...

    • Hemophagocytic syndrome in patients from SLE Registry from the Spanish Society of Rheumatology (RELESSER) 

      Lois Iglesias, Ana J.; Rua Figueroa, I.; De-Toro, Javier; Zea-Mendoza, A.; López-Longo, J.; Calvo, J.; Galindo, M.; Uriarte-Isacelaya, E.; Pego-Reigosa, J. (BMJ, 2017)

    • High-Throughput Screen Detects Calcium Signaling Dysfunction in Hutchinson-Gilford Progeria Syndrome 

      Fafián Labora, Juan Antonio; Morente López, Miriam; De-Toro, Javier; Arufe, M.C. (MDPI, 2021-07-07)
      [Abstract] Hutchinson–Gilford progeria syndrome (HGPS) is a deadly childhood disorder, which is considered a very rare disease. It is caused by an autosomal dominant mutation on the LMNA gene, and it is characterized by ...

    • Human amniotic membrane as an alternative source of stem cells for regenerative medicine 

      Díaz-Prado, Silvia; Muiños-López, Emma; Hermida Gómez, Tamara; Cicione, Claudia; Rendal Vázquez, María Esther; Fuentes Boquete, Isaac Manuel; De-Toro, Javier; Blanco García, Francisco J (Elsevier, 2011-02-19)
      [Abstract] The human amniotic membrane (HAM) is a highly abundant and readily available tissue. This amniotic tissue has considerable advantageous characteristics to be considered as an attractive material in the field of ...

    • Human amniotic mesenchymal stromal cells as favorable source for cartilage repair 

      Muiños-López, Emma; Hermida Gómez, Tamara; Fuentes Boquete, Isaac Manuel; De-Toro, Javier; Blanco García, Francisco J; Díaz-Prado, Silvia (Mary Ann Liebert, 2017-01-10)
      [Abstract] Introduction: Localized trauma-derived breakdown of the hyaline articular cartilage may progress toward osteoarthritis, a degenerative condition characterized by total loss of articular cartilage and joint ...

    • Human cartilage engineering in an in vitro repair model using collagen scaffolds and mesenchymal stromal cells 

      Sanjurjo-Rodríguez, Clara; Castro Viñuelas, Rocío; Hermida Gómez, Tamara; Fuentes Boquete, Isaac Manuel; De-Toro, Javier; Blanco García, Francisco J; Díaz-Prado, Silvia (Ivyspring, 2017-09-28)
      [Abstract] The purpose of this study was to investigate cartilage repair of in vitro lesion models using human bone marrow mesenchymal stromal cells (hBMSCs) with different collagen (Col) scaffolds. Lesions were made ...

    • Hydrogel-Based Localized Nonviral Gene Delivery in Regenerative Medicine Approaches: an Overview 

      Carballo-Pedrares, Natalia; Fuentes Boquete, Isaac Manuel; Díaz-Prado, Silvia; Rey-Rico, Ana (MDPI, 2020-08-10)
      [Abstract] Hydrogel-based nonviral gene delivery constitutes a powerful strategy in various regenerative medicine scenarios, as those concerning the treatment of musculoskeletal, cardiovascular, or neural tissues disorders ...

    • Hydrogen sulfide and inflammatory joint diseases 

      Burguera, Elena F.; Meijide-Faílde, Rosa; Blanco García, Francisco J (Bentham, 2017)
      [Abstract] Background: Rheumatoid arthritis (RA) and osteoarthritis (OA) are widespread rheumatic diseases characterized by persistent inflammation and joint destruction. Hydrogen sulfide (H2S) is an endogenous gas with ...

    • Hydrogen sulfide biosynthesis is impaired in the osteoarthritic joint 

      Burguera, Elena F.; Vela Anero, Ángela; Gato Calvo, Lucía; Vaamonde-García, Carlos; Meijide-Faílde, Rosa; Blanco García, Francisco J (Springer, 2019-11-16)
      [Abstract] Osteoarthritis (OA) is the most common form of arthritis and it is a leading cause of disability in the elderly. Its complete etiology is not known although there are several metabolic, genetic, epigenetic, and ...