Listar Terapia Celular e Medicina Rexenerativa por autor "Díaz-Prado, Silvia"
Mostrando ítems 1-20 de 51
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Alternative protocols to induce chondrogenic differentiation: transforming growth factor-β superfamily
Cicione, Claudia; Muiños Gómez, Emma; Hermida Gómez, Tamara; Fuentes Boquete, Isaac Manuel; Díaz-Prado, Silvia; Blanco García, Francisco J (Springer, 2014-09-10)[Abstract] Mesenchymal stem cells (MSCs) are an accepted candidate for cell-based therapy of multiple diseases. The interest in MSCs and their possible application in cell therapy have resulted in a better understanding ... -
An artificial-vision- and statistical-learning-based method for studying the biodegradation of type I collagen scaffolds in bone regeneration systems
Robles-Bykbaev, Yaroslava; Naya, Salvador; Díaz-Prado, Silvia; Calle-López, D.; Robles-Bykbaev, Vladimir; Garzón, Luis; Sanjurjo-Rodríguez, Clara; Tarrío-Saavedra, Javier (PeerJ, 2019-07-05)[Abstract] This work proposes a method based on image analysis and machine and statistical learning to model and estimate osteocyte growth (in type I collagen scaffolds for bone regeneration systems) and the collagen ... -
Analysis of Cryopreservation Protocols and Their Harmful Effects on the Endothelial Integrity of Human Corneas
Rodríguez-Fernández, Silvia; Álvarez-Portela, Marcelino; Rendal Vázquez, María Esther; Piñeiro-Ramil, María; Sanjurjo-Rodríguez, Clara; Castro Viñuelas, Rocío; Sánchez-Ibáñez, Jacinto; Fuentes Boquete, Isaac Manuel; Díaz-Prado, Silvia (MDPI, 2021-11-22)[Abstract] Corneal cryopreservation can partially solve the worldwide concern regarding donor cornea shortage for keratoplasties. In this study, human corneas were cryopreserved using two standard cryopreservation protocols ... -
Biology of BMP signalling and cancer
Blanco, Moisés; Bolós Fernández, Victoria; Medina Villaamil, Vanessa; Aparicio Gallego, Guadalupe; Díaz-Prado, Silvia; Grande Pulido, Enrique (Springer, 2009)[Abstract] In recent years, it has been proposed that tumours are not homogeneous but composed of several cellular types like normal tissues. A cellular subtype, which is though to be the origin of tumours as well as their ... -
Bone marrow cells immunomagnetically selected for CD271+ antigen promote in vitro the repair of articular cartilage defects
Hermida Gómez, Tamara; Fuentes Boquete, Isaac Manuel; Gimeno-Longas, María José; Muíños-López, Emma; Díaz-Prado, Silvia; De-Toro, Javier; Blanco García, Francisco J (Mary Ann Liebert, 2011-03-22)[Abstract] Objective: The purposes of this project were to quantify the cells expressing the mesenchymal stem cell (MSC) marker CD271 in synovial membranes from human osteoarthritic (OA) and healthy joints, and to determine ... -
Cartilage tissue engineering: adult human mesenchymal stromal cells and collagen biomaterials
Sanjurjo-Rodríguez, Clara; Martínez Sánchez, A.H.; Hermida Gómez, Tamara; Fuentes Boquete, Isaac Manuel; Buján, J.; De-Toro, Javier; Díaz-Prado, Silvia; Blanco García, Francisco J (Elsevier, 2014-03-20) -
Cell and Tissue Transplant Strategies for Joint Lesions
Fuentes Boquete, Isaac Manuel; Arufe, M.C.; Díaz-Prado, Silvia; Hermida Gómez, Tamara; De-Toro, Javier; Blanco García, Francisco J (Bentham Open, 2008-07-11)[Abstract] Articular cartilage lesions that do not disrupt the integrity of subchondral bone are not capable of spontaneous repair. The asymptomatic nature of these lesions leads to articular cartilage degeneration and ... -
Cell therapy and tissue engineering for cartilage repair
Piñeiro-Ramil, María; Castro Viñuelas, Rocío; Sanjurjo-Rodríguez, Clara; Hermida Gómez, Tamara; Fuentes Boquete, Isaac Manuel; De-Toro, Javier; Blanco García, Francisco J; Díaz-Prado, Silvia (IntechOpen, 2018-02-14)[Abstract] The integrity of the articular cartilage is necessary for the proper functioning of the diarthrodial joint. The self-repair capacity of this tissue is very limited and, currently, there is no effective treatment ... -
Cell viability assay in corneal endothelium
Rodríguez-Fernández, Silvia; Álvarez Portela, Marcelino; Rendal Vázquez, María Esther; Montero Salinas, Alejandro; Piñeiro-Ramil, María; Castro Viñuelas, Rocío; Rojas, María Victoria de; Sánchez Ibáñez, Jacinto; Fuentes Boquete, Isaac Manuel; Díaz-Prado, Silvia (2018)[Abstract] Introduction: Endothelium is the inner layer of the cornea, which must be viable for transplanting. The limited availability of corneas makes necessary the developing of preservation ... -
Characterization of microRNA expression profiles in normal and osteoarthritic human chondrocytes
Díaz-Prado, Silvia; Cicione, Claudia; Muiños-López, Emma; Hermida Gómez, Tamara; Oreiro, Natividad; Fernández-López, Carlos; Blanco García, Francisco J (BioMed Central, 2012-08-12)[Abstract] Background. Osteoarthritis (OA) is a multifactorial disease characterized by destruction of the articular cartilage due to environmental, mechanical and genetic components. The genetics of OA is complex and ... -
Corneal cryopreservation: and endothelial cell viability and histomorphological study of cornea
Rodríguez-Fernández, Silvia; Álvarez Portela, Marcelino; Rendal Vázquez, María Esther; Montero Salinas, Alejandro; Piñeiro-Ramil, María; Castro Viñuelas, Rocío; Rojas, María Victoria de; Sánchez Ibáñez, Jacinto; Fuentes Boquete, Isaac Manuel; Díaz-Prado, Silvia (2019) -
Criopreservación de córnea: estudio de la viabilidad celular endotelial y de la histomofología de la córnea
Rodríguez-Fernández, Silvia; Álvarez Portela, Marcelino; Rendal Vázquez, María Esther; Montero Salinas, Alejandro; Piñeiro-Ramil, María; Castro Viñuelas, Rocío; Rojas, María Victoria de; Sánchez Ibáñez, Jacinto; Fuentes Boquete, Isaac Manuel; Díaz-Prado, Silvia (2019) -
Cryopreservation effect on proliferative and chondrogenic potential of human chondrocytes isolated from superficial and deep cartilage
Muíños López, Emma; Rendal Vázquez, María Esther; Hermida Gómez, Tamara; Fuentes Boquete, Isaac Manuel; Díaz-Prado, Silvia; Blanco García, Francisco J (Bentham Open, 2012-04-06)[Abstract] Objectives: To compare the proliferative and chondrogenic potential of fresh and frozen chondrocytes isolated from superficial and deep articular cartilage biopsies. Materials and Methodology: The study ... -
Current Development of Alternative Treatments for Endothelial Decompensation: Cell-Based Therapy
Rodríguez-Fernández, Silvia; Piñeiro-Ramil, María; Castro Viñuelas, Rocío; Sanjurjo-Rodríguez, Clara; Álvarez Portela, Marcelino; Fuentes Boquete, Isaac Manuel; Rendal Vázquez, María Esther; Díaz-Prado, Silvia (Elsevier, 2021-04-01)[Abstract] Current treatment for corneal endothelial dysfunction consists in the replacement of corneal endothelium by keratoplasty. Owing to the scarcity of donor corneas and the increasing number of transplants, alternative ... -
Detección de la viabilidad celular sobre endotelio corneal
Rodríguez-Fernández, Silvia; Álvarez Portela, Marcelino; Rendal Vázquez, María Esther; Montero Salinas, Alejandro; Piñeiro-Ramil, María; Castro Viñuelas, Rocío; Rojas, María Victoria de; Sánchez Ibáñez, Jacinto; Fuentes Boquete, Isaac Manuel; Díaz-Prado, Silvia (2018) -
Diagnostic accuracy of small breast epithelial mucin mRNA as a marker for bone marrow micrometastasis in breast cancer: a pilot study
Valladares-Ayerbes, Manuel; Iglesias-Díaz, Pilar; Díaz-Prado, Silvia; Ayude, Daniel; Medina Villaamil, Vanessa; Haz, Mar; Reboredo, Margarita; Antolín, Silvia; Calvo, Lourdes; Antón-Aparicio, Luis M. (Springer-Verlag, 2009-02-17)[Abstract] Background. Detection of isolated tumour cells (ITC) in the blood or minimal deposits in distant organs such as bone marrow (BM) could be important to identify breast cancer patients at high risk of relapse or ... -
Differentiation of human mesenchymal stromal cells cultured on collagen sponges for cartilage repair
Sanjurjo-Rodríguez, Clara; Martínez Sánchez, Adela Helvia; Hermida Gómez, Tamara; Fuentes Boquete, Isaac Manuel; Díaz-Prado, Silvia; Blanco García, Francisco J (Sociedad Española de Histología e Ingeniería Tisular, 2016)[Abstract] Aim: The aim of this study was to evaluate proliferation and chondrogenic differentiation of human bone-marrow mesenchymal stromal cells (hBMSCs) cultured on collagen biomaterials. Materials and methods: ... -
Effects of severe hypoxia on bone marrow mesenchymal stem cells differentiation potential
Cicione, Claudia; Muiños-López, Emma; Hermida Gómez, Tamara; Fuentes Boquete, Isaac Manuel; Díaz-Prado, Silvia; Blanco García, Francisco J (Hindawi, 2013-06-30)[Abstract] Background. The interests in mesenchymal stem cells (MSCs) and their application in cell therapy have resulted in a better understanding of the basic biology of these cells. Recently hypoxia has been indicated ... -
Establishment of human induced pluripotent stem cell-lines (IPSC) for in vitro modelling hand ostheoarthritis.
Castro Viñuelas, Rocío; Sanjurjo-Rodríguez, Clara; Piñeiro-Ramil, María; Hermida Gómez, Tamara; Fuentes Boquete, Isaac Manuel; De-Toro, Javier; Blanco García, Francisco J; Díaz-Prado, Silvia (BMJ Journals, 2019-05-27) -
Evaluation of COX-2, EGFR, and p53 as biomarkers of non-dysplastic oral leukoplakias
Díaz-Prado, Silvia; López Cedrún, José Luis; Luaces Rey, Ramón; Medina Villaamil, Vanessa; Álvarez García, Augusto; Valladares-Ayerbes, Manuel; Antón-Aparicio, Luis M. (Elsevier, 2010-07-01)[Abstract] Objective. Identify candidate SEBs (surrogate endpoint biomarkers) for premalignant trends in head and neck mucosa. Study design. Study, by qPCR (quantitative real-time polymerase chain reaction), the expression ...