Current Development of Alternative Treatments for Endothelial Decompensation: Cell-Based Therapy

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Current Development of Alternative Treatments for Endothelial Decompensation: Cell-Based TherapyAuthor(s)
Date
2021-04-01Citation
Rodríguez-Fernández S, Piñeiro-Ramil M, Castro-Viñuelas R, Sanjurjo-Rodríguez C, Álvarez-Portela M, Fuentes-Boquete IM, et al. Current development of alternative treatments for endothelial decompensation: Cell-based therapy. Exp Eye Res. 2021;207:108560.
Abstract
[Abstract]
Current treatment for corneal endothelial dysfunction consists in the replacement of corneal endothelium by keratoplasty. Owing to the scarcity of donor corneas and the increasing number of transplants, alternative treatments such as cell-based therapies are necessary. In this article, we highlight the biological aspects of the cornea and the corneal endothelium, as well as the context that surrounds the need for new alternatives to conventional keratoplasty. We then review some of those experimental treatments in more detail, focusing on the development of the in vitro and preclinical phases of two cell-based therapies: tissue-engineered endothelial keratoplasty (TE-EK) and cell injection. In the case of TE-EK graft construction, we analyse the current progress, considering all the requirements it must meet in order to be functional. Moreover, we discuss the inherent drawbacks of endothelial keratoplasties, which TE-EK grafts should overcome in order to make surgical intervention easier and to improve the outcomes of current endothelial keratoplasties. Finally, we analyse the development of preclinical trials and their limitations in terms of performing an optimal functional evaluation of cell-based therapy, and we conclude by discussing early clinical trials in humans.
Keywords
Corneal endothelium
Endothelial decompensation
Transplantation
Endothelial keratoplasty
Cell-based therapy
Tissue engineering
Cell injection
Endothelial regeneration
Animal model
Endothelial decompensation
Transplantation
Endothelial keratoplasty
Cell-based therapy
Tissue engineering
Cell injection
Endothelial regeneration
Animal model
Description
Financiado para publicación en acceso aberto: Universidade da Coruña/CISUG
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Rights
Creative Commons Attribution 4.0 International Licence (CC BY 4.0)
ISSN
0014-4835
1096-0007
1096-0007