Listar Instituto de Investigación Biomédica da Coruña (INIBIC) por data de publicación

Mostrando ítems 1-20 de 755

    • Mitochondrial activity is modulated by TNFα and IL-1β in normal human chondrocyte cells 

      López-Armada, María José; Caramés, Beatriz; Martín, M.A.; Cillero-Pastor, B.; Lires-Dean, M.; Fuentes Boquete, Isaac Manuel; Arenas, J.; Blanco García, Francisco J (Elsevier, 2006-05-05)
      [Abstract] Objective. Pro-inflammatory cytokines play an important role in osteoarthritis (OA). In osteoarthritic cartilage, chondrocytes exhibit an alteration in mitochondrial activity. This study analyzes the effect of ...

    • Bioinformatics approach to mRNA markers discovery for detection of circulating tumor cells in patients with gastrointestinal cancer 

      Valladares-Ayerbes, Manuel; Díaz-Prado, Silvia; Reboredo, Margarita; Medina Villaamil, Vanessa; Iglesias-Díaz, Pilar; Lorenzo-Patiño, María J.; García Campelo, Rosario; Haz, Mar; Santamarina, Isabel; Antón-Aparicio, Luis M. (Elsevier, 2008)
      [Abstract] Background: Detection of tumor cells in the blood, or minimal deposits in distant organs as bone marrow, could be important to identify cancer patients at high risk of relapse or disease progression. Quantitative ...

    • Cell and Tissue Transplant Strategies for Joint Lesions 

      Fuentes Boquete, Isaac Manuel; Arufe, M.C.; Díaz-Prado, Silvia; Hermida Gómez, Tamara; De-Toro, Javier; Blanco García, Francisco J (Bentham Open, 2008-07-11)
      [Abstract] Articular cartilage lesions that do not disrupt the integrity of subchondral bone are not capable of spontaneous repair. The asymptomatic nature of these lesions leads to articular cartilage degeneration and ...

    • Tratamiento de lesiones del cartílago articular con terapia celular 

      Fuentes Boquete, Isaac Manuel; Arufe, M.C.; Díaz-Prado, Silvia; Hermida Gómez, Tamara; De-Toro, Javier; Blanco García, Francisco J (Elsevier, 2008-11-13)
      [Resumen] Las lesiones del cartílago articular que no afectan a la integridad del hueso subcondral no se reparan espontáneamente. El carácter asintomático de estas lesiones propicia la progresiva degeneración articular y ...

    • Hedgehog signalling as a target in cancer stem cells 

      Medina Villaamil, Vanessa; Blanco, Moisés; Díaz-Prado, Silvia; Espada, Jesús (Spirnger, 2009)
      [Abstract] Hedgehog (Hh) is one of the most important signalling pathways. Together with the Wnt, TGF-β/BMP and Notch pathways, it is involved in both embryonic development and adult tissue homeostasis. This is because Hh ...

    • Expression of Wnt gene family and frizzled receptors in head and neck squamous cell carcinomas 

      Díaz-Prado, Silvia; Medina Villaamil, Vanessa; Aparicio Gallego, Guadalupe; Blanco, Moisés; López Cedrún, José Luis; Sironvalle Soliva, Sheila; Valladares-Ayerbes, Manuel; García Campelo, Rosario; Antón-Aparicio, Luis M. (Spirnger, 2009)
      [Abstract] Genes of the Wnt and Frizzled class, expressed in HNSCC tissue and cell lines, have an established role in cell morphogenesis and differentiation, and also they have oncogenic properties. We studied Wnt and Fz ...

    • Notch signalling in cancer stem cells 

      Bolós Fernández, Victoria; Medina Villaamil, Vanessa; Aparicio Gallego, Guadalupe; Díaz-Prado, Silvia; Grande Pulido, Enrique (Springer, 2009)
      [Abstract] A new theory about the development of solid tumours is emerging from the idea that solid tumours, like normal adult tissues, contain stem cells (called cancer stem cells) and arise from them. Genetic mutations ...

    • Biology of BMP signalling and cancer 

      Blanco, Moisés; Bolós Fernández, Victoria; Medina Villaamil, Vanessa; Aparicio Gallego, Guadalupe; Díaz-Prado, Silvia; Grande Pulido, Enrique (Springer, 2009)
      [Abstract] In recent years, it has been proposed that tumours are not homogeneous but composed of several cellular types like normal tissues. A cellular subtype, which is though to be the origin of tumours as well as their ...

    • Mixed burst and tonic firing in the thalamus: a study in the feline lateral geniculate nucleus in vivo 

      Grieve, Kenneth; Rivadulla, Casto; Cudeiro, Javier (Elsevier, 2009)
      [Abstract] Compounds known to inhibit or disfacilitate cells in cat dorsal lateral geniculate nucleus (dLGN) were applied iontophoretically in vivo. Application of GABA, or agonists of GABAA and GABAB receptors, markedly ...

    • Differentiation of Murine Embryonic Stem Cells to Thyrocytes Requires Insulin and Insulin-like Growth Factor-1 

      Arufe, M.C.; Lu, Min; Lin, Reigh-Yi (Elsevier, 2009-02-14)
      [Abstract] The mechanisms controlling thyrocyte development during embryonic stem (ES) cell differentiation have only been partially elucidated, although previous studies have suggested the participation of thyroid stimulating ...

    • Diagnostic accuracy of small breast epithelial mucin mRNA as a marker for bone marrow micrometastasis in breast cancer: a pilot study 

      Valladares-Ayerbes, Manuel; Iglesias-Díaz, Pilar; Díaz-Prado, Silvia; Ayude, Daniel; Medina Villaamil, Vanessa; Haz, Mar; Reboredo, Margarita; Antolín, Silvia; Calvo, Lourdes; Antón-Aparicio, Luis M. (Springer-Verlag, 2009-02-17)
      [Abstract] Background. Detection of isolated tumour cells (ITC) in the blood or minimal deposits in distant organs such as bone marrow (BM) could be important to identify breast cancer patients at high risk of relapse or ...

    • Differentiation of Synovial CD-105+ Human Mesenchymal Stem Cells into Chondrocyte-like Cells through Spheroid Formation 

      Arufe, M.C.; Fuente, Alexandre de la; Fuentes Boquete, Isaac Manuel; De-Toro, Javier; Blanco García, Francisco J (Wiley, 2009-06-18)
      [Abstract] Mesenchymal stem cells (MSCs) have the capacity to differentiate into several cell lineages, some of which can generate bone, cartilage, or adipose tissue. The presence of MSCs in the synovial membrane was ...

    • Wnt signalling and cancer stem cells 

      Espada, Jesús; Calvo, Moisés B.; Díaz-Prado, Silvia; Medina, Vanessa (Springer, 2009-07-15)
      [Abstract] Intracellular signalling mediated by secreted Wnt proteins is essential for the establishment of cell fates and proper tissue patterning during embryo development and for the regulation of tissue homeostasis and ...

    • Different sources of nitric oxide mediate neurovascular coupling in the lateral geniculate nucleus of the cat 

      Labra, Carmen de; Rivadulla, Casto; Espinosa, Nelson; Dasilva, Miguel; Cao, Ricardo; Cudeiro, Javier (Frontiers, 2009-09-08)
      [Abstract] Understanding the link between neuronal responses (NRs) and metabolic signals is fundamental to our knowledge of brain function and it is a milestone in our efforts to interpret data from modern non invasive ...

    • Effect of ghrelin on glucose-insulin homeostasis: therapeutic implications 

      Sangiao-Alvarellos, Susana; Cordido, Fernando (Hindawi, 2010)
      [Abstract] Ghrelin is a 28-amino-acid peptide that displays a strong growth hormone- (GH-) releasing activity through the activation of the growth hormone secretagogue receptor (GHSR). The first studies about role of ghrelin ...

    • Peritoneal protein transport during the baseline peritoneal equilibration test is an accurate predictor of the outcome of peritoneal dialysis patients 

      Pérez-Fontán, Miguel; Rodríguez Carmona, Ana; Barreda, D.; López-Muñiz, Andrés; Blanco-Castro, N.; García Falcón, María Teresa (Karger, 2010)
      [Abstract] Background: Peritoneal protein excretion (PPE) is a potential marker of the outcome in peritoneal dialysis (PD) patients. Method: Observational study of a cohort of 269 patients starting PD in a single unit. ...

    • Molecular profile and cellular characterization of human bone marrow mesenchymal stem cells: donor influence on chondrogenesis 

      Cicione, Claudia; Díaz-Prado, Silvia; Muiños-López, Emma; Hermida Gómez, Tamara; Blanco García, Francisco J (Elsevier, 2010)
      [Abstract] Background. The use of autologous or allogenic stem cells has recently been suggested as an alternative therapeutic approach for treatment of cartilage defects. Bone marrow mesenchymal stem cells (BM-MSCs) are ...

    • Approved and off-label uses of obesity medications, and potential new pharmacologic treatment options 

      Isidro, María Luisa; Cordido, Fernando (MDPI, 2010-01-12)
      [Abstract] Available anti-obesity pharmacotherapy options remain very limited and development of more effective drugs has become a priority. The potential strategies to achieve weight loss are to reduce energy intake by ...

    • Potential use of the human amniotic membrane as a scaffold in human articular cartilage repair 

      Díaz-Prado, Silvia; Rendal Vázquez, María Esther; Muiños-López, Emma; Hermida Gómez, Tamara; Rodríguez-Cabarcos, Margarita; Fuentes Boquete, Isaac Manuel; De-Toro, Javier; Blanco García, Francisco J (Springer, 2010-04-13)
      [Abstract] The human amniotic membrane (HAM) is an abundant and readily obtained tissue that may be an important source of scaffold for transplanted chondrocytes in cartilage regeneration in vivo. To evaluate the potential ...

    • Evaluation of Plakophilin-3 mRNA as a biomarker for detection of circulating tumor cells in gastrointestinal cancer patients 

      Valladares-Ayerbes, Manuel; Díaz-Prado, Silvia; Reboredo, Margarita; Medina, Vanessa; Lorenzo-Patiño, María J.; Iglesias-Díaz, Pilar; Haz, Mar; Pértega-Díaz, Sonia; Santamarina, Isabel; Blanco, Moisés; Quindós-Varela, María; Figueroa, Angélica; Antón-Aparicio, Luis M. (American Association for Cancer Research, 2010-05-25)
      [Abstract] Background: This study aims to assess Plakophilin-3 (PKP3) as a surrogate biomarker of circulating tumor cells in patients with gastrointestinal cancer. Methods: The primary aim is to estimate the diagnostic ...