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NF-κB/IKK Activation by Small Extracellular Vesicles Within the SASP
(Wiley, 2021-06-29)
[Abstract] Cellular senescence plays an important role in different biological and pathological conditions. Senescent cells communicate with their microenvironment through a plethora of soluble factors, metalloproteases ...
Small Extracellular Vesicles Have GST Activity and Ameliorate Senescence-Related Tissue Damage
(Elsevier, 2020-07-07)
[Abstract]
Aging is a process of cellular and tissue dysfunction characterized by different hallmarks, including cellular senescence. However, there is proof that certain features of aging and senescence can be ameliorated. ...
Extracellular Vesicles as Potential Tools for Regenerative Therapy
(Taylor & Francis Online, 2020-09-08)
[Abstract]
Small extracellular vesicles released by fibroblasts from young human donors diminish lipid peroxidation
in senescent cells and in different old mice organs due to their enrichment in Glutathione-S-transferase
Mu ...
Classical and nonclassical intercellular communication in senescence and ageing
(Cell Press, 2020-06-03)
[Abstract] Intercellular communication refers to the different ways through which cells communicate with each other and transfer a variety of messages. These communication methods involve a number of different processes ...
Generation of mesenchymal cell lines derived from aged donors
(MDPI, 2021-10-01)
[Abstract] Background: Mesenchymal stromal cells (MSCs) have the capacity for self-renewal and multi-differentiation, and for this reason they are considered a potential cellular source in regenerative medicine of cartilage ...