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Regulation of Angiogenesis Discriminates Tissue Resident MSCs from Effective and Defective Osteogenic Environments
(MDPI, 2020-05-28)
[Abstract] Background: The biological mechanisms that contribute to atrophic long bone non-union
are poorly understood. Multipotential mesenchymal stromal cells (MSCs) are key contributors to bone
formation and are ...
rAAV-Mediated Overexpression of SOX9 and TGF-β via Carbon Dot-Guided Vector Delivery Enhances the Biological Activities in Human Bone Marrow-Derived Mesenchymal Stromal Cells
(MDPI, 2020-04-28)
[Abstract]
Scaffold-assisted gene therapy is a highly promising tool to treat articular cartilage lesions
upon direct delivery of chondrogenic candidate sequences. The goal of this study was to examine
the feasibility ...
Biomaterial-Assisted Gene Therapy for Translational Approaches to Treat Musculoskeletal Disorders
(Elsevier, 2020-12-28)
[Abstract]
Biomaterial-assisted gene therapy is a promising strategy for the treatment of various musculoskeletal disorders such as those concerning the articular cartilage, bones, tendons and ligaments, and meniscus as ...
Scaffold-Mediated Gene Delivery for Osteochondral Repair
(MDPI, 2020-09-29)
[Abstract]
Osteochondral defects involve both the articular cartilage and the underlying subchondral
bone. If left untreated, they may lead to osteoarthritis. Advanced biomaterial-guided delivery of gene
vectors has ...
Therapeutic Delivery of rAAV sox9 via Polymeric Micelles Counteracts the Effects of Osteoarthritis-Associated Inflammatory Cytokines in Human Articular Chondrocytes
(MDPI, 2020-06-25)
[Abstract]
Osteoarthritis (OA) is a prevalent joint disease linked to the irreversible degradation of key extracellular cartilage matrix (ECM) components (proteoglycans, type-II collagen) by proteolytic enzymes due to an ...
A Pilot Randomized Controlled Trial of Aquatic-Based Activities in a Group Occupational Therapy Program for Adults Living With Serious Mental Illness in Spain
(Wiley, 2021-08-17)
[Abstract] Although aquatic-based interventions are increasingly used in the psychiatric rehabilitation services, the effects of this type of community program as an adjuvant therapy for psychosocial problems of people ...
Valor pronóstico de la resonancia magnética precoz en la morbilidad y mortalidad de la lesión medular traumática
(Elsevier, 2022-02-12)
[Resumen] Objetivo. Valorar en individuos con lesión medular traumática (LMT) la relación entre la mortalidad y la necesidad de UCI y las alteraciones objetivadas mediante resonancia magnética (RM) precoz, analizando ...
Action mechanisms of small extracellular vesicles in inflammaging
(MDPI, 2022-04-06)
[Abstract] The accumulation process of proinflammatory components in the body due to aging influences intercellular communication and is known as inflammaging. This biological mechanism relates the development of inflammation ...
Acellular Nerve Graft Enriched With Mesenchymal Stem Cells in the Transfer of the Phrenic Nerve to the Musculocutaneous Nerve in a C5-C6 Brachial Plexus Avulsion in a Rat Model
(Wiley, 2021-10-18)
[Abstract] Introduction: Phrenic nerve transfer has been shown to achieve good nerve regeneration in brachial plexus avulsion. Acellular nerve allografts (ANAs) showed inferior results to autografts, which is why its use ...
Therapeutic Potential for Regulation of the Nuclear Factor Kappa-B Transcription Factor p65 to Prevent Cellular Senescence and Activation of Pro-Inflammatory in Mesenchymal Stem Cells
(MDPI, 2021-03-25)
[Abstract]
Mesenchymal stem cells have an important potential in the treatment of age-related diseases.
In the last years, small extracellular vesicles derived from these stem cells have been proposed as
cell-free ...