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Regulation of Angiogenesis Discriminates Tissue Resident MSCs from Effective and Defective Osteogenic Environments
(MDPI, 2020-05-28)
[Abstract] Background: The biological mechanisms that contribute to atrophic long bone non-union
are poorly understood. Multipotential mesenchymal stromal cells (MSCs) are key contributors to bone
formation and are ...
Myofascial release therapy in the treatment of occupational mechanical neck pain: a randomized parallel group study
(Wolters Kluwer, 2016-07)
[Abstract] Objective: As myofascial release therapy is currently under development, the objective of this study was to compare the effectiveness of myofascial release therapy with manual therapy for treating occupational ...
Epidemiology of traumatic spinal cord injury in Galicia, Spain: trends over a 20-year period
(Nature, 2017-02-14)
[Abstract] Study design: Observational study with prospective and retrospective monitoring.
Objective: To describe the epidemiological and demographic characteristics of traumatic spinal cord injury (TSCI), and to analyze ...
Analysis of the Chondrogenic Potential and Secretome of Mesenchymal Stem Cells Derived from Human Umbilical Cord Stroma
(Mary Ann Liebert, 2011-06-28)
[Abstract] Mesenchymal stem cells (MSCs) from umbilical cord stroma were isolated by plastic adherence and characterized by flow cytometry, looking for cells positive for OCT3/4 and SSEA-4 as well as the classic MSC markers ...
rAAV-Mediated Overexpression of SOX9 and TGF-β via Carbon Dot-Guided Vector Delivery Enhances the Biological Activities in Human Bone Marrow-Derived Mesenchymal Stromal Cells
(MDPI, 2020-04-28)
[Abstract]
Scaffold-assisted gene therapy is a highly promising tool to treat articular cartilage lesions
upon direct delivery of chondrogenic candidate sequences. The goal of this study was to examine
the feasibility ...
Biomaterial-Assisted Gene Therapy for Translational Approaches to Treat Musculoskeletal Disorders
(Elsevier, 2020-12-28)
[Abstract]
Biomaterial-assisted gene therapy is a promising strategy for the treatment of various musculoskeletal disorders such as those concerning the articular cartilage, bones, tendons and ligaments, and meniscus as ...
Scaffold-Mediated Gene Delivery for Osteochondral Repair
(MDPI, 2020-09-29)
[Abstract]
Osteochondral defects involve both the articular cartilage and the underlying subchondral
bone. If left untreated, they may lead to osteoarthritis. Advanced biomaterial-guided delivery of gene
vectors has ...
Chondrogenic Potential of Subpopulations of Cells Expressing Mesenchymal Stem Cell Markers Derived from Human Synovial Membranes
(Wiley, 2010-07-21)
[Abstract] In this study we analyzed the chondrogenic potential of subpopulations of mesenchymal stem cells (MSCs) derived from human synovial membranes enriched for CD73, CD106, and CD271 markers. Subpopulations of human ...
Therapeutic Delivery of rAAV sox9 via Polymeric Micelles Counteracts the Effects of Osteoarthritis-Associated Inflammatory Cytokines in Human Articular Chondrocytes
(MDPI, 2020-06-25)
[Abstract]
Osteoarthritis (OA) is a prevalent joint disease linked to the irreversible degradation of key extracellular cartilage matrix (ECM) components (proteoglycans, type-II collagen) by proteolytic enzymes due to an ...
Gene expression and functional comparison between multipotential stromal cells from lateral and medial condyles of knee osteoarthritis patients
(Nature Publishing Group, 2019-06-29)
[Abstract] Osteoarthritis (OA) is the most common degenerative joint disorder. Multipotential stromal cells (MSCs) have a crucial role in joint repair, but how OA severity affects their characteristics remains unknown. ...