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rAAV-Mediated Overexpression of SOX9 and TGF-β via Carbon Dot-Guided Vector Delivery Enhances the Biological Activities in Human Bone Marrow-Derived Mesenchymal Stromal Cells
(MDPI, 2020-04-28)
[Abstract]
Scaffold-assisted gene therapy is a highly promising tool to treat articular cartilage lesions
upon direct delivery of chondrogenic candidate sequences. The goal of this study was to examine
the feasibility ...
Biomaterial-Assisted Gene Therapy for Translational Approaches to Treat Musculoskeletal Disorders
(Elsevier, 2020-12-28)
[Abstract]
Biomaterial-assisted gene therapy is a promising strategy for the treatment of various musculoskeletal disorders such as those concerning the articular cartilage, bones, tendons and ligaments, and meniscus as ...
Scaffold-Mediated Gene Delivery for Osteochondral Repair
(MDPI, 2020-09-29)
[Abstract]
Osteochondral defects involve both the articular cartilage and the underlying subchondral
bone. If left untreated, they may lead to osteoarthritis. Advanced biomaterial-guided delivery of gene
vectors has ...
Therapeutic Delivery of rAAV sox9 via Polymeric Micelles Counteracts the Effects of Osteoarthritis-Associated Inflammatory Cytokines in Human Articular Chondrocytes
(MDPI, 2020-06-25)
[Abstract]
Osteoarthritis (OA) is a prevalent joint disease linked to the irreversible degradation of key extracellular cartilage matrix (ECM) components (proteoglycans, type-II collagen) by proteolytic enzymes due to an ...
PEO-PPO-PEO tri-block copolymers for gene delivery applications in human regenerative medicine: an overview
(MDPI, 2018-03-08)
[Abstract] Lineal (poloxamers or Pluronic®) or X-shaped (poloxamines or Tetronic®) amphiphilic tri-block copolymers of poly(ethylene oxide) and poly(propylene oxide) (PEO-PPO-PEO) have been broadly explored for controlled ...
Hydrogel-based localized nonviral gene delivery in regenerative medicine approaches: an overview
(MDPI, 2020-08-10)
[Abstract]
Hydrogel-based nonviral gene delivery constitutes a powerful strategy in various
regenerative medicine scenarios, as those concerning the treatment of musculoskeletal, cardiovascular,
or neural tissues disorders ...
Therapeutic effects of rAAV-mediated concomittant gene transfer and overexpression of TGF-β and IGF-I on the chondrogenesis of human bone-marrow-derived mesenchymal stem cells
(MDPI, 2019-05-27)
[Abstract] Application of chondroreparative gene vectors in cartilage defects is a powerful approach to directly stimulate the regenerative activities of bone-marrow-derived mesenchymal stem cells (MSCs) that repopulate ...
Niosomes-Based Gene Delivery Systems for Effective Transfection of Human Mesenchymal Stem Cells
(Elsevier, 2021-07-11)
[Abstract] Gene transfer to mesenchymal stem cells (MSCs) has arisen as a powerful approach to increase the therapeutic potential of this effective cell population. Over recent years, niosomes have emerged as self-assembled ...
Current trends in viral gene therapy for human orthopaedic regenerative medicine
(Springer, 2019-02-21)
[Abstract] Background: Viral vector-based therapeutic gene therapy is a potent strategy to enhance the intrinsic reparative abilities of human orthopaedic tissues. However, clinical application of viral gene transfer remains ...
Controlled Release of rAAV Vectors from APMA-Functionalized Contact Lenses for Corneal Gene Therapy
(MDPI, 2020-04-09)
[Abstract]
As an alternative to eye drops and ocular injections for gene therapy, the aim of this work
was to design for the first time hydrogel contact lenses that can act as platforms for the controlled
delivery of ...