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Enhancing physical activity programs for diabetic patients at high and very high cardiovascular risk
(Universitatea Nationala de Stiinta si Tehnologie Politehnica Bucaresti, 2023-10-31)
[Abstract] This study aimed to identify the populations most susceptible to cardiovascular risks, aligning with the 2021
ESC guidelines. Additionally, this study aimed to evaluate statin prescriptions to determine suitable ...
Therapeutic Potential for Regulation of the Nuclear Factor Kappa-B Transcription Factor p65 to Prevent Cellular Senescence and Activation of Pro-Inflammatory in Mesenchymal Stem Cells
(MDPI, 2021-03-25)
[Abstract]
Mesenchymal stem cells have an important potential in the treatment of age-related diseases.
In the last years, small extracellular vesicles derived from these stem cells have been proposed as
cell-free ...
Genome Wide CRISPR/Cas9 Screen Identifies the Coagulation Factor IX (F9) as a Regulator of Senescence
(Nature, 2022-02-19)
[Abstract] During this last decade, the development of prosenescence therapies has become an attractive strategy as cellular senescence acts as a barrier against tumour progression. In this context, CDK4/6 inhibitors induce ...
Global DNA Methylation in Dental Implant Failure Due to Peri-Implantitis: An Exploratory Clinical Pilot Study
(MDPI, 2022-01-17)
[Abstract] Background: Peri-implantitis (PIT) is highly prevalent in patients with dental implants and is a challenging condition to treat due to the limited outcomes reported for non-surgical and surgical therapies. ...
Therapy free of cells vs human mesenchymal stem cells from umbilical cord stroma to treat the inflammation in OA
(Springer, 2022-10-20)
[Abstract] Osteoarthritis (OA) is closely linked to the increase in the number of senescent cells in joint tissues, and the senescence-associated secretory phenotype (SASP) is implicated in cartilage degradation. In the ...
High-Throughput Screen Detects Calcium Signaling Dysfunction in Hutchinson-Gilford Progeria Syndrome
(MDPI, 2021-07-07)
[Abstract] Hutchinson–Gilford progeria syndrome (HGPS) is a deadly childhood disorder, which is considered a very rare disease. It is caused by an autosomal dominant mutation on the LMNA gene, and it is characterized by ...
The Experience With Health Care of Patients With Inflammatory Arthritis: A Cross-sectional Survey Using the Instrument to Evaluate the Experience of Patients With Chronic Diseases
(Wolters Kluwer, 2021-01-27)
[Abstract]
Background: Patients' experience with health care is becoming a key component for the provision of a patient-centered health care model. The aim of this study was to assess the experience with health care of ...
NF-κB/IKK Activation by Small Extracellular Vesicles Within the SASP
(Wiley, 2021-06-29)
[Abstract] Cellular senescence plays an important role in different biological and pathological conditions. Senescent cells communicate with their microenvironment through a plethora of soluble factors, metalloproteases ...
Classical and nonclassical intercellular communication in senescence and ageing
(Cell Press, 2020-06-03)
[Abstract] Intercellular communication refers to the different ways through which cells communicate with each other and transfer a variety of messages. These communication methods involve a number of different processes ...
Extracellular Vesicles as Potential Tools for Regenerative Therapy
(Taylor & Francis Online, 2020-09-08)
[Abstract]
Small extracellular vesicles released by fibroblasts from young human donors diminish lipid peroxidation
in senescent cells and in different old mice organs due to their enrichment in Glutathione-S-transferase
Mu ...