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Building-Scale Wastewater-Based Epidemiology for SARS-CoV-2 Surveillance at Nursing Homes in A Coruña, Spain
dc.contributor.author | Trigo-Tasende, Noelia | |
dc.contributor.author | Vallejo, J.A. | |
dc.contributor.author | Rumbo-Feal, Soraya | |
dc.contributor.author | Conde-Pérez, Kelly | |
dc.contributor.author | Nasser-Ali, Mohammed | |
dc.contributor.author | Tarrío-Saavedra, Javier | |
dc.contributor.author | Barbeito, Inés | |
dc.contributor.author | Cao, Ricardo | |
dc.contributor.author | Ladra, Susana | |
dc.contributor.author | Bou, Germán | |
dc.contributor.author | Poza, Margarita | |
dc.date.accessioned | 2024-07-03T16:38:38Z | |
dc.date.available | 2024-07-03T16:38:38Z | |
dc.date.issued | 2023-11 | |
dc.identifier.citation | Trigo-Tasende, N., Vallejo, J. A., Rumbo-Feal, S., Conde-Pérez, K., Nasser-Ali, M., Tarrío-Saavedra, J., et. al. (2023). Building-Scale Wastewater-Based Epidemiology for SARS-CoV-2 Surveillance at Nursing Homes in A Coruña, Spain. Environments 10(11). https://doi.org/10.3390/environments10110189 | es_ES |
dc.identifier.issn | 2076-3298 | |
dc.identifier.uri | http://hdl.handle.net/2183/37693 | |
dc.description | Financiado para publicación en acceso aberto: Universidade da Coruña/CISUG | es_ES |
dc.description.abstract | [Abstract] Wastewater-based epidemiology (WBE) has become an effective tool in the surveillance of infectious diseases such as COVID-19. In this work, we performed a brief study of monitoring the SARS-CoV-2 viral load in wastewater from six nursing homes located in the metropolitan area of A Coruña (Spain) between December 2020 and March 2021. The main objective was to detect SARSCoV- 2 outbreaks among residents and study the efficacy of the vaccination campaign. SARS-CoV-2 viral load (RNA copies per L of wastewater) was determined by reverse-transcription quantitative PCR (RT-qPCR) using the quantification cycle (Cq) values for the nucleocapsid (N) gene. Our results showed that the increase in viral load preceded the increase in clinical cases, favoring an early warning system that detects COVID-19 outbreaks in advance, making it possible to contain and stop the transmission of the virus among residents. In addition, the efficacy of the new COVID-19 vaccines was evidenced, since after the vaccination campaign in nursing homes in A Coruña, it was observed that many residents did not present any symptoms of the disease, although they excreted high amounts of virus in their feces. WBE is a cost-effective strategy that should be implemented in all cities to prevent new emerging diseases or future pandemic threats. | es_ES |
dc.description.sponsorship | EDAR Bens S.A.; INV04020 | es_ES |
dc.description.sponsorship | EDAR Bens S.A.; INV12120 | es_ES |
dc.description.sponsorship | EDAR Bens S.A.; INV05921 | es_ES |
dc.description.sponsorship | EDAR Bens S.A.; INV148721 | es_ES |
dc.description.sponsorship | Xunta de Galicia; IN607A 2016/22 | es_ES |
dc.description.sponsorship | Xunta de Galicia; ED431C-2016/015 | es_ES |
dc.description.sponsorship | Xunta de Galicia; ED431C-2020/14 | es_ES |
dc.description.sponsorship | Xunta de Galicia; ED431C 2021/53 | es_ES |
dc.description.sponsorship | Xunta de Galicia; ED431G 2019/01 | es_ES |
dc.description.sponsorship | Xunta de Galicia; COV20/00604 | es_ES |
dc.description.sponsorship | Funding for open access charge: Universidade da Coruña/CISUG. This work was mainly supported by the grant INV00821 from Consellería de Política Social (Xunta de Galicia, Spain) to M.P. The team was also supported by EDAR Bens S.A., A Coruña, Spain (grant references INV04020, INV12120, INV05921, and INV148721 to M.P.), by the National Plan for Scientific Research, Development and Technological Innovation funded by the Institute of Health Carlos III (ISCIII), Spain—General Subdirection of Assessment and Promotion of the Research-European Regional Development Fund (FEDER) “A way of making Europe” [grant references PI15/00860 to G.B., PI17/01482 and PI20/00413 to M.P.], by the Galician Innovation Agency (GAIN) (Xunta de Galicia, Spain) [grant references IN607A 2016/22 to G.B., ED431C-2016/015 and ED431C-2020/14 to R.C., ED431C 2021/53 to S.L., and ED431G 2019/01 and COV20/00604 to R.C. and S.L., by the Ministry of Economic Affairs and Digital Transformation (MINECO), Spain (grant references MTM2017-82724-R to R.C.), by the Spanish Network of Research in Infectious Diseases (CIBERINFEC, ISCIII, reference CB21/13/00055), and by the European Virus Archive Global (EVA-GLOBAL) project that has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No 871029. S.R.-F. was financially supported by REIPI RD16/0016/006, K.C.-P. by IN607A 2016/22 and the Spanish Association against Cancer (AECC), and J.A.V. by IN607A 2016/22. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | MDPI | es_ES |
dc.relation | info:eu-repo/grantAgreement/EC/H2020/871029 | es_ES |
dc.relation | info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/PI15%2F00860/ES/Desarrollo de una plataforma universal de vacunas bacterianas vivas atenuadas auxótrofas para D-glutamato: prevención y erradicación de infecciones por bacterias multirresistentes/ | |
dc.relation | info:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/PI17%2F01482/ES/EVALUACION DE NUEVAS ESTRATEGIAS ANTIMICROBIANAS MEDIANTE SILENCIAMIENTO DE ARN VEHICULIZADO EN NANOCAPSULAS E INHIBIDORES ENZIMATICOS/ | |
dc.relation | info:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PI20%2F00413/ES/FARMACOMICROBIOMICA Y MEDICINA PERSONALIZADA EN LA TERAPIA DEL CANCER COLORECTAL/ | |
dc.relation | info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/MTM2017-82724-R/ES/INFERENCIA ESTADISTICA FLEXIBLE PARA DATOS COMPLEJOS DE GRAN VOLUMEN Y DE ALTA DIMENSION/ | |
dc.relation.uri | https://doi.org/10.3390/environments10110189 | es_ES |
dc.rights | Atribución 4.0 Internacional | es_ES |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | COVID-19 | es_ES |
dc.subject | Epidemiology | es_ES |
dc.subject | Nursing home | es_ES |
dc.subject | Early warning | es_ES |
dc.subject | Environmental surveillance | es_ES |
dc.subject | Public health | es_ES |
dc.subject | Wastewater | es_ES |
dc.subject | SARS-CoV-2 | es_ES |
dc.subject | WBE | es_ES |
dc.title | Building-Scale Wastewater-Based Epidemiology for SARS-CoV-2 Surveillance at Nursing Homes in A Coruña, Spain | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.access | info:eu-repo/semantics/openAccess | es_ES |
UDC.journalTitle | Environments | es_ES |
UDC.volume | 10 | es_ES |
UDC.issue | 11 | es_ES |
dc.identifier.doi | https://doi.org/10.3390/environments10110189 |
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