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Electrochemically Controlled Cleavage of Imine Bonds on a Graphene Platform: Towards New Electro-Responsive Hybrids for Drug Release

dc.contributor.authorHou, Huilei
dc.contributor.authorCardo, Lucia
dc.contributor.authorMancino, Donato
dc.contributor.authorArnaiz, Blanca
dc.contributor.authorCriado, Alejandro
dc.contributor.authorPrato, Maurizio
dc.date.accessioned2024-06-27T15:37:40Z
dc.date.available2024-06-27T15:37:40Z
dc.date.issued2020-11-25
dc.identifier.citationNanoscale, 2020, 12, 23824es_ES
dc.identifier.issn2040-3372
dc.identifier.urihttp://hdl.handle.net/2183/37510
dc.description.abstract[Abstract] Graphene-based materials are particularly suitable platforms for the development of new systems able to release drugs upon the application of controlled electrochemical stimuli. Herein, we report a new electro-responsive graphene carrier functionalised with aldehydes (as drug models) through imine-based linkers. We explore a new type of drug loading/release combination based on the formation of a covalent bond and its cleavage upon electrolysis. The new graphene–drug model hybrid is stable under physiological conditions and displays a fast drug release upon the application of low voltages.es_ES
dc.description.sponsorshipM. Prato is the recipient of the AXA Chair (2016–2023). A. Criado, H.-L. Hou and D. Mancino thank MINECO for their research grants (Juan de la Cierva – Incorporación No. IJCI-2016-31113 and IJC-2018-037396 for A. Criado and H.-L. Hou, respectively; and FPI No. BES-2017-081563 for D. Mancino). This work was supported by the Graphene Flagship Core 2 and Core 3 grant agreement (No. 785219 and 881603, respectively) and EU H2020-MSCA-RISE-2016 (No. 734381). This work was performed under the Maria de Maeztu Units of Excellence Program from the Spanish State Research Agency – Grant No. MDM-2017-0720.es_ES
dc.language.isoenges_ES
dc.publisherRoyal Society of Chemistryes_ES
dc.relationinfo:eu-repo/grantAgreement/EC/H2020/785219es_ES
dc.relationinfo:eu-repo/grantAgreement/EC/H2020/881603es_ES
dc.relationinfo:eu-repo/grantAgreement/EC/H2020/734381es_ES
dc.relationinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/IJC-2018-037396-I/ES/es_ES
dc.relationinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/BES-2017-081563/ES/es_ES
dc.relationinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/IJCI-2016-31113/ES/es_ES
dc.relationinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/MDM-2017-0720/ES/es_ES
dc.relation.urihttps://doi.org/10.1039/D0NR04102Ees_ES
dc.rightsAtribución-NoComercial 3.0
dc.rights.urihttps://creativecommons.org/licenses/by-nc/3.0/
dc.subjectGraphenees_ES
dc.subjectPhysiological modelses_ES
dc.subjectTargeted drug deliveryes_ES
dc.subjectCovalent bondes_ES
dc.subjectDrug Liberationes_ES
dc.subjectImineses_ES
dc.titleElectrochemically Controlled Cleavage of Imine Bonds on a Graphene Platform: Towards New Electro-Responsive Hybrids for Drug Releasees_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.accessinfo:eu-repo/semantics/openAccesses_ES
UDC.journalTitleNanoscalees_ES
UDC.issue12es_ES
UDC.startPage23824es_ES
UDC.endPage23830es_ES
dc.identifier.doi10.1039/D0NR04102E


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