Electrochemically Controlled Cleavage of Imine Bonds on a Graphene Platform: Towards New Electro-Responsive Hybrids for Drug Release
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Electrochemically Controlled Cleavage of Imine Bonds on a Graphene Platform: Towards New Electro-Responsive Hybrids for Drug ReleaseDate
2020-11-25Citation
Nanoscale, 2020, 12, 23824
Abstract
[Abstract] Graphene-based materials are particularly suitable platforms for the development of new systems able to release drugs upon the application of controlled electrochemical stimuli. Herein, we report a new electro-responsive graphene carrier functionalised with aldehydes (as drug models) through imine-based linkers. We explore a new type of drug loading/release combination based on the formation of a covalent bond and its cleavage upon electrolysis. The new graphene–drug model hybrid is stable under physiological conditions and displays a fast drug release upon the application of low voltages.
Keywords
Graphene
Physiological models
Targeted drug delivery
Covalent bond
Drug Liberation
Imines
Physiological models
Targeted drug delivery
Covalent bond
Drug Liberation
Imines
Editor version
Rights
Atribución-NoComercial 3.0
ISSN
2040-3372