Mostrar o rexistro simple do ítem
FASN activity is important for the initial stages of the induction of senescence
dc.contributor.author | Fafián Labora, Juan Antonio | |
dc.contributor.author | Carpintero-Fernández, Paula | |
dc.contributor.author | Jordan, Samuel James Davison | |
dc.contributor.author | Shikh-Bahaei, Tamanna | |
dc.contributor.author | Abdullah, Sana Mohammad | |
dc.contributor.author | Mahenthiran, Midusa | |
dc.contributor.author | Rodríguez-Navarro, José Antonio | |
dc.contributor.author | Niklison-Chirou, María Victoria | |
dc.contributor.author | O’Loghlen, Ana | |
dc.date.accessioned | 2024-06-06T09:49:52Z | |
dc.date.available | 2024-06-06T09:49:52Z | |
dc.date.issued | 2019-04-08 | |
dc.identifier.citation | Fafián-Labora J, Carpintero-Fernández P, Jordan SJD, Shikh-Bahaei T, Abdullah SM, Mahenthiran M, Rodríguez-Navarro JA, Niklison-Chirou MV, O'Loghlen A. FASN activity is important for the initial stages of the induction of senescence. Cell Death Dis. 2019 Apr 8;10(4):318. | es_ES |
dc.identifier.issn | 2041-4889 | |
dc.identifier.uri | http://hdl.handle.net/2183/36820 | |
dc.description.abstract | [Abstract] Senescent cells accumulate in several tissues during ageing and contribute to several pathological processes such as ageing and cancer. Senescence induction is a complex process not well defined yet and is characterized by a series of molecular changes acquired after an initial growth arrest. We found that fatty acid synthase (FASN) levels increase during the induction of senescence in mouse hepatic stellate cells and human primary fibroblasts. Importantly, we also observed a significant increase in FASN levels during ageing in mouse liver tissues. To probe the central role of FASN in senescence induction, we used a small-molecule inhibitor of FASN activity, C75. We found that C75 treatment prevented the induction of senescence in mouse and human senescent cells. Importantly, C75 also reduced the expression of the signature SASP factors interleukin 1α (IL-1α), IL-1β and IL-6, and suppressed the secretion of small extracellular vesicles. These findings were confirmed using a shRNA targeting FASN. In addition, we find that FASN inhibition induces metabolic changes in senescent cells. Our work underscores the importance of C75 as a pharmacological inhibitor for reducing the impact of senescent cell accumulation. | es_ES |
dc.description.sponsorship | This work was funded by Children with Cancer UK (Number: 14–178) awarded to M.V.N.-C., the BBSRC (BB/P000223/1) and The Royal Society (RG170399) awarded to A.O.L., and the Nacional Health Institute Carlos III-Miguel-Servet (CP13-00234) and MINECO (SAF2016-78666 R) awarded to J.A.R.-N. J.F.-L. and P.C.-F. are funded by the Xunta de Galicia Fellowships (ED481B 2017/117 and IN606B 2017/014 respectivelly). | es_ES |
dc.description.sponsorship | Biotechnology and Biological Sciences Research Council (United KIngdom); BB/P000223/1 | es_ES |
dc.description.sponsorship | Royal Society (United Kingdom); RG170399 | es_ES |
dc.description.sponsorship | info:eu-repo/grantAgreement/MINECO/Programa Estatal de I+D+I Orientada a los Retos de la Sociedad/CP13%2F00234/ES/ | es_ES |
dc.description.sponsorship | Ministerio de Economía y Competitividad (España) ; SAF2016-78666R | es_ES |
dc.description.sponsorship | Xunta de Galicia; ED481B 2017/117 | es_ES |
dc.description.sponsorship | Xunta de Galicia; IN606B 2017/014 | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Springer Nature | es_ES |
dc.relation.uri | https://doi.org/10.1038/s41419-019-1550-0 | es_ES |
dc.rights | Creative Commons Attribution 4.0 International License (CC-BY 4.0) | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | Cellular Senescence | es_ES |
dc.subject | Fatty Acid Synthase, Type I | es_ES |
dc.subject | Fibroblast | es_ES |
dc.subject | Hepatic Stellate Cells | es_ES |
dc.subject | Mitochondria | es_ES |
dc.title | FASN activity is important for the initial stages of the induction of senescence | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.access | info:eu-repo/semantics/openAccess | es_ES |
UDC.journalTitle | Cell Death & Disease | es_ES |
UDC.volume | 10 | es_ES |
UDC.startPage | 318 | es_ES |
dc.identifier.doi | 10.1038/s41419-019-1550-0 |
Ficheiros no ítem
Este ítem aparece na(s) seguinte(s) colección(s)
-
GI-TCMR - Artigos [129]