PEO-PPO-PEO tri-block copolymers for gene delivery applications in human regenerative medicine: an overview
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PEO-PPO-PEO tri-block copolymers for gene delivery applications in human regenerative medicine: an overviewDate
2018-03-08Citation
Rey-Rico A, Cucchiarini M. PEO-PPO-PEO tri-block copolymers for gene delivery applications in human regenerative medicine: an overview. 2018;19(3):775
Abstract
[Abstract] Lineal (poloxamers or Pluronic®) or X-shaped (poloxamines or Tetronic®) amphiphilic tri-block copolymers of poly(ethylene oxide) and poly(propylene oxide) (PEO-PPO-PEO) have been broadly explored for controlled drug delivery in different regenerative medicine approaches. The ability of these copolymers to self-assemble as micelles and to undergo sol-to-gel transitions upon heating has endowed the denomination of “smart” or “intelligent” systems. The use of PEO-PPO-PEO copolymers as gene delivery systems is a powerful emerging strategy to improve the performance of classical gene transfer vectors. This review summarizes the state of art of the application of PEO-PPO-PEO copolymers in both nonviral and viral gene transfer approaches and their potential as gene delivery systems in different regenerative medicine approaches.
Keywords
PEO-PPO-PEO copolymers
Nonviral vectors
Viral vectors
Gene transfer
Nonviral vectors
Viral vectors
Gene transfer
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Atribución 3.0 España
ISSN
1422-0067