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AGT haplotype in ITGA4 gene is related to antibody-mediated rejection in heart transplant patients
dc.contributor.author | Núñez, Lucía | |
dc.contributor.author | Marrón Liñares, Grecia Manuela | |
dc.contributor.author | Crespo-Leiro, María Generosa | |
dc.contributor.author | Barge-Caballero, Eduardo | |
dc.contributor.author | Álvarez López, Eloy | |
dc.contributor.author | Suárez-Fuentetaja, Natalia | |
dc.contributor.author | Paniagua-Martín, María J. | |
dc.contributor.author | Pombo-Otero, Jorge | |
dc.contributor.author | Muñiz, Javier | |
dc.contributor.author | Tan, Carmela D. | |
dc.contributor.author | Rene Rodríguez, E. | |
dc.contributor.author | Vázquez Rodríguez, José Manuel | |
dc.date.accessioned | 2019-10-21T10:53:29Z | |
dc.date.available | 2019-10-21T10:53:29Z | |
dc.date.issued | 2019-07-23 | |
dc.identifier.citation | Núñez L, Marrón-Liñares GM, Crespo-Leiro MG et al. AGT haplotype in ITGA4 gene is related to antibody-mediated rejection in heart transplant patients. PloS One. 2019; 14(7):e0219345. | es_ES |
dc.identifier.issn | 1932-6203 | |
dc.identifier.uri | http://hdl.handle.net/2183/24161 | |
dc.description.abstract | [Abstract] Introduction. One of the main problems involved in heart transplantation (HT) is antibody-mediated rejection (AMR). Many aspects of AMR are still unresolved, including its etiology, diagnosis and treatment. In this project, we hypothesize that variants in genes involved in B-cell biology in HT patients can yield diagnostic and prognostic information about AMR. Methods. Genetic variants in 61 genes related to B-cell biology were analyzed by next generation sequencing in 46 HT patients, 23 with and 23 without AMR. Results. We identified 3 single nucleotide polymorphisms in ITGA4 gene (c.1845G>A, c.2633A>G, and c.2883C>T) that conformed the haplotype AGT-ITGA4. This haplotype is associated with the development of AMR. Moreover, AMR patients with the haplotype AGT-ITGA4 present lower levels of integrin α-4 in serum samples compared to the reference GAC haplotype in control patients. Conclusion. We can conclude that polymorphisms in genes related to the biology of B-cells could have an important role in the development of AMR. In fact, the AGT haplotype in ITGA4 gene could potentially increase the risk of AMR. | es_ES |
dc.description.sponsorship | Instituto de Salud Carlos III; PI13/02174 | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Stanislaw Stepkowski, | es_ES |
dc.relation.uri | https://doi.org/10.1371/journal.pone.0219345 | es_ES |
dc.rights | Atribución 4.0 Internacional | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.title | AGT haplotype in ITGA4 gene is related to antibody-mediated rejection in heart transplant patients | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.access | info:eu-repo/semantics/openAccess | es_ES |
UDC.journalTitle | PlosOne | es_ES |
UDC.volume | 14 | es_ES |
UDC.issue | 7 | es_ES |
UDC.endPage | e0219345 | es_ES |
dc.identifier.doi | 10.1371/journal.pone.0219345 |
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