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Effect of aging on behaviour of mesenchymal stem cells
dc.contributor.author | Fafián Labora, Juan Antonio | |
dc.contributor.author | Morente-López, Miriam | |
dc.contributor.author | Arufe, M.C. | |
dc.date.accessioned | 2019-10-09T11:07:08Z | |
dc.date.available | 2019-10-09T11:07:08Z | |
dc.date.issued | 2019-06-26 | |
dc.identifier.citation | Fafián-Labora JA, Morente-López M, Arufe MC. Effect of aging on behaviour of mesenchymal stem cells. World J Stem Cells 2019; 11(6): 337-346. | es_ES |
dc.identifier.issn | 1948-0210 | |
dc.identifier.uri | http://hdl.handle.net/2183/24068 | |
dc.description.abstract | [Abstract] Organs whose source is the mesoderm lineage contain a subpopulation of stem cells that are able to differentiate among mesodermal derivatives (chondrocytes, osteocytes, adipocytes). This subpopulation of adult stem cells, called “mesenchymal stem cells” or “mesenchymal stromal cells (MSCs)”, contributes directly to the homeostatic maintenance of their organs; hence, their senescence could be very deleterious for human bodily functions. MSCs are easily isolated and amenable their expansion in vitro because of the research demanding to test them in many diverse clinical indications. All of these works are shown by the rapidly expanding literature that includes many in vivo animal models. We do not have an in-depth understanding of mechanisms that induce cellular senescence, and to further clarify the consequences of the senescence process in MSCs, some hints may be derived from the study of cellular behaviour in vivo and in vitro, autophagy, mitochondrial stress and exosomal activity. In this particular work, we decided to review these biological features in the literature on MSC senescence over the last three years. | es_ES |
dc.description.sponsorship | Supported by Consellería de Cultura, Educación e Ordenación Universitaria, Xunta de Galicia (Spain), Fafián-Labora JA is recipient of a postdoctoral fellowship (ED481B 2017/117). | es_ES |
dc.description.sponsorship | Xunta de Galicia; ED481B 2017/117 | |
dc.language.iso | eng | es_ES |
dc.publisher | Baishideng Publishing Group Inc. | es_ES |
dc.relation.uri | https://doi.org/10.4252/wjsc.v11.i6.337 | es_ES |
dc.rights | Creative Commons Attribution 4.0 International License (CC-BY 4.0) | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by-nc/4.0/ | * |
dc.subject | Mesenchymal stem cells | es_ES |
dc.subject | Aging | es_ES |
dc.subject | Autophagy | es_ES |
dc.subject | Mitochondrial stress | es_ES |
dc.subject | Extracellular vesicles | es_ES |
dc.title | Effect of aging on behaviour of mesenchymal stem cells | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.access | info:eu-repo/semantics/openAccess | es_ES |
UDC.journalTitle | World Journal of Stem Cells | es_ES |
UDC.volume | 11 | es_ES |
UDC.issue | 6 | es_ES |
UDC.startPage | 337 | es_ES |
UDC.endPage | 346 | es_ES |
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