Listar Reumatoloxía por autor "Blanco García, Francisco J"
Mostrando ítems 21-40 de 171
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Association of serum anti-centromere protein F antibodies with clinical response to infliximab in patients with rheumatoid arthritis: a prospective study
Lourido Salas, Lucía María; Ruiz-Romero, Cristina; Picchi, Florencia; Diz-Rosales, Naomi; Vilaboa Galán, Sergio; Fernández-López, Carlos; Pinto-Tasende, José A.; Pérez-Pampin, Eva; Regueiro, Cristina; Mera-Varela, Antonio; González, Antonio; Hambardzumyan, Karen; Saevarsdottir, Saedis; Nilsson, Peter; Blanco García, Francisco J (Elsevier, 2020-06-30)[Abstract] Background: One-third of rheumatoid arthritis (RA) patients demonstrate no clinical improvement after receiving tumor necrosis factor inhibitors (TNFi). The presence of serum autoantibodies is a hallmark in RA ... -
Association of the serological status of rheumatoid arthritis patients with two circulating protein biomarkers: a useful tool for precision medicine strategies
Ruiz-Romero, Cristina; Fernández-Puente, Patricia; González, Lucía; Illiano, Anna; Lourido, Lucía; Paz, Rocío; Quaranta, Patricia; Pérez-Pampín, Eva; González, Antonio; Blanco García, Francisco J; Calamia, Valentina (Frontiers, 2022-10-28)[Abstract] Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic inflammation of the joints and presence of systemic autoantibodies, with a great clinical and molecular heterogeneity. Rheumatoid Factor ... -
Autophagy activation by resveratrol reduces severity of experimental rheumatoid arthritis
Fernández-Rodríguez, Jennifer Adriana; Almonte-Becerril, Maylin; Ramil-Gómez, Olalla; Hermida-Carballo, Laura; Viñas-Diz, Susana; Vela-Anero, Á.; Concha, Ángel; Camacho Encina, María; Blanco García, Francisco J; López-Armada, María José (Wiley, 2020-11-12) -
Baseline clinical characteristics of predicted structural and pain progressors in the IMI-APPROACH knee OA cohort
van Helvoort, Eefje M.; Ladel, Christoph H.; Mastbergen, Simon; Kloppenburg, Margreet; Blanco García, Francisco J; Haugen, Ida K.; Berenbaum, Francis; Bacardit, Jaume; Widera, Pawel; Welsing, Paco M.J.; Lafeber, Floris (BMJ, 2021-08-23)[Abstract] Objectives: To describe the relations between baseline clinical characteristics of the Applied Public-Private Research enabling OsteoArthritis Clinical Headway (IMI-APPROACH) participants and their predicted ... -
Biodistribution and immunogenicity of allogeneic mesenchymal stem cells in a rat model of intraarticular chondrocyte xenotransplantation
Marquina, Maribel; Collado, Javier A.; Pérez-Cruz, Magdiel; Fernández-Pernas, Pablo; Fafián Labora, Juan Antonio; Blanco García, Francisco J; Máñez, Rafael; Arufe, M.C.; Costa, Cristina (Frontiers, 2017-11-06)[Abstract] Xenogeneic chondrocytes and allogeneic mesenchymal stem cells (MSC) are considered a potential source of cells for articular cartilage repair. We here assessed the immune response triggered by xenogeneic ... -
Bone marrow cells immunomagnetically selected for CD271+ antigen promote in vitro the repair of articular cartilage defects
Hermida Gómez, Tamara; Fuentes Boquete, Isaac Manuel; Gimeno-Longas, María José; Muíños-López, Emma; Díaz-Prado, Silvia; De-Toro, Javier; Blanco García, Francisco J (Mary Ann Liebert, 2011-03-22)[Abstract] Objective: The purposes of this project were to quantify the cells expressing the mesenchymal stem cell (MSC) marker CD271 in synovial membranes from human osteoarthritic (OA) and healthy joints, and to determine ... -
Can gait patterns be explained by joint structure in people with and without radiographic knee osteoarthritis?: data from the IMI-APPROACH cohort
Jansen, Mylène P.; Hodgins, Diana; Mastbergen, Simon C.; Kloppenburg, Margreet; Blanco García, Francisco J; Haugen, Ida K.; Berenbaum, Francis; Eckstein, Felix; Roemer, Frank W.; Wirt, Wolfgang (Springer Nature, 2024-03-27)[Abstract] Objective: To determine the association between joint structure and gait in patients with knee osteoarthritis (OA). Methods: IMI-APPROACH recruited 297 clinical knee OA patients. Gait data was collected ... -
Cardiovascular disease in immune-mediated inflammatory diseases: a cross-sectional analysis of 6 cohorts
Fernández-Gutiérrez, Benjamín; Perrotti, Pedro P.; Gisbert, Javier P.; Doménech, Eugeni; Fernández-Nebro, Antonio; Cañete, Juan D.; Ferrándiz, Carlos; Tornero, Jesús; García-Sánchez, Valle; Panés, Julián; Fonseca, Eduardo; Blanco García, Francisco J; Rodríguez-Moreno, Jesús; Carreira, Patricia; Juliá, Antonio; Marsal, Sara; Rodríguez-Rodríguez, Luis (Wolters Kluwer, 2017-06)[Abstract] To analyze in several immune-mediated inflammatory diseases (IMIDs) the influence of demographic and clinical-related variables on the prevalence of cardiovascular disease (CVD), and compare their standardized ... -
Cartilage tissue engineering: adult human mesenchymal stromal cells and collagen biomaterials
Sanjurjo-Rodríguez, Clara; Martínez Sánchez, A.H.; Hermida Gómez, Tamara; Fuentes Boquete, Isaac Manuel; Buján, J.; De-Toro, Javier; Díaz-Prado, Silvia; Blanco García, Francisco J (Elsevier, 2014-03-20) -
CD105+-mesenchymal stem cells migrate into osteoarthritis joint: an animal model
Fernández-Pernas, Pablo; Rodríguez-Lesende, Iván; Fuente, Alexandre de la; Mateos, Jesús; Fuentes Boquete, Isaac Manuel; De-Toro, Javier; Blanco García, Francisco J; Arufe, M.C. (PLoS, 2017-11-30)[Abstract] Mesenchymal stem cells are being the focus of connective tissue technology and regenerative medicine, presenting a good choice cell source for improving old and well recognized techniques of cartilage defect ... -
Cell therapy and tissue engineering for cartilage repair
Piñeiro-Ramil, María; Castro Viñuelas, Rocío; Sanjurjo-Rodríguez, Clara; Hermida Gómez, Tamara; Fuentes Boquete, Isaac Manuel; De-Toro, Javier; Blanco García, Francisco J; Díaz-Prado, Silvia (IntechOpen, 2018-02-14)[Abstract] The integrity of the articular cartilage is necessary for the proper functioning of the diarthrodial joint. The self-repair capacity of this tissue is very limited and, currently, there is no effective treatment ... -
Characterization of microRNA expression profiles in normal and osteoarthritic human chondrocytes
Díaz-Prado, Silvia; Cicione, Claudia; Muiños-López, Emma; Hermida Gómez, Tamara; Oreiro, Natividad; Fernández-López, Carlos; Blanco García, Francisco J (BioMed Central, 2012-08-12)[Abstract] Background. Osteoarthritis (OA) is a multifactorial disease characterized by destruction of the articular cartilage due to environmental, mechanical and genetic components. The genetics of OA is complex and ... -
Chondrogenic Potential of Subpopulations of Cells Expressing Mesenchymal Stem Cell Markers Derived from Human Synovial Membranes
Arufe, M.C.; Fuente, Alexandre de la; Fuentes Boquete, Isaac Manuel; De-Toro, Javier; Blanco García, Francisco J (Wiley, 2010-07-21)[Abstract] In this study we analyzed the chondrogenic potential of subpopulations of mesenchymal stem cells (MSCs) derived from human synovial membranes enriched for CD73, CD106, and CD271 markers. Subpopulations of human ... -
Clinical, Patient-Reported, and Ultrasound Outcomes from an Open-Label, 12-week Observational Study of Certolizumab Pegol in Spanish Patients with Rheumatoid Arthritis with or without Prior Anti-TNF Exposure
Blanco García, Francisco J; Rubio-Romero, Esteban; Sanmartí, Raimon; Díaz-Torné, César; Talavera, Pablo; Dunkel, Jochen; Naredo, Esperanza (Elsevier, 2018-09-17)[Abstract] Objectives: To assess the effectiveness and safety of certolizumab pegol (CZP) in Spanish patients with RA. Materials and methods: SONAR (NCT01526434), a 12-week, open-label, prospective, observational, ... -
Cohort profile: the Applied Public-Private Research enabling OsteoArthritis Clinical Headway (IMI-APPROACH) study: a 2-year, European, cohort study to describe, validate and predict phenotypes of osteoarthritis using clinical, imaging and biochemical markers
van Helvoort, Eefje M.; van Spil, Willem E.; Jansen, Mylène P.; Welsing, Paco M.J.; Kloppenburg, Margreet; Loef, Marieke; Blanco García, Francisco J; Haugen, Ida K.; Berenbaum, Francis; Bacardit, Jaume; Ladel, Christoph H.; Loughlin, John; Bay-Jensen, Anne C.; Mobasheri, Ali; Larkin, Jonathan; Boere, Janneke; Weinans, Harrie H.; Lalande, Agnes; Marijnissen, Anne C.A.; Lafeber, Floris (BMJ, 2020-07-28)[Abstract] Purpose The Applied Public-Private Research enabling OsteoArthritis Clinical Headway (APPROACH) consortium intends to prospectively describe in detail, preselected patients with knee osteoarthritis (OA), using ... -
Combined chondroitin sulfate and glucosamine for painful knee osteoarthritis: a multicentre, randomised, double-blind, non-inferiority trial versus celecoxib
Hochberg, Marc C.; Martel-Pelletier, Johanne; Monfort, Jordi; Möller, Ingrid; Castillo, Juan Ramón; Arden, Nigel; Berenbaum, Francis; Blanco García, Francisco J; Conaghan, Philip G.; Domènech, Gema; Henrotin, Yves; Pap, Thomas; Richette, Pascal; Sawitze, Allen; Souich, Patrick du; Pelletier, Jean-Pierre (BMJ, 2015-01-14)[Abstract] Objectives. To compare the efficacy and safety of chondroitin sulfate plus glucosamine hydrochloride (CS+GH) versus celecoxib in patients with knee osteoarthritis and severe pain. Methods. Double-blind ... -
Core outcome measurement instrument selection for physical function in hand osteoarthritis using the OMERACT Filter 2.1 process
Kroon, Féline P.B.; van der Heijde, Désirée; Maxwell, Lara J.; Beaton, Dorcas E.; Abishek, Abishek; Berenbaum, Francis; Blanco García, Francisco J; Conaghan, Philip G.; Dziedzic, Krysia; Hill, Catherine L.; Haugen, Ida K.; Ishimori, Mariko; Ritschl, Valentin; Stamm, Tanja A.; Wittoek, Ruth; Kopplenburg, Margreet (Elsevier, 2021-12)[Abstract] Objective: Physical function is one of the Outcome Measures in Rheumatology (OMERACT) core outcome domains for hand osteoarthritis studies. Our aim was to select appropriate instrument(s) to measure this domain, ... -
Cryopreservation effect on proliferative and chondrogenic potential of human chondrocytes isolated from superficial and deep cartilage
Muíños López, Emma; Rendal Vázquez, María Esther; Hermida Gómez, Tamara; Fuentes Boquete, Isaac Manuel; Díaz-Prado, Silvia; Blanco García, Francisco J (Bentham Open, 2012-04-06)[Abstract] Objectives: To compare the proliferative and chondrogenic potential of fresh and frozen chondrocytes isolated from superficial and deep articular cartilage biopsies. Materials and Methodology: The study ... -
Defective chaperone-mediated autophagy is a hallmark of joint disease in patients with knee osteoarthritis
Lorenzo-Gómez, I.; Nogueira Recalde, Uxía; García-Domínguez, C.; Oreiro, Natividad; Lotz, Martin; Pinto-Tasende, José A.; Blanco García, Francisco J; Caramés, Beatriz (Elsevier, 2023-03-08)[Abstract] Objective: Defects in autophagy contribute to joint aging and Osteoarthritis (OA). Identifying specific autophagy types could be useful for developing novel treatments for OA. Design: An autophagy-related ... -
Descripción de la cohorte PROCOAC (PROspective COhort of A Coruña): cohorte prospectiva española para el estudio de la osteoartritis
Oreiro, Natividad; Raga, Ana C.; Rego-Pérez, Ignacio; Pértega-Díaz, Sonia; Silva-Díaz, María T.; Freire, Mercedes; Fernández-López, Carlos; Blanco García, Francisco J (Elsevier, 2020-11-13)[Resumen] Introducción y objetivo. El uso de cohortes de osteoartritis bien caracterizadas es obligatorio para estudiar y profundizar en el conocimiento en esta enfermedad. En España no existe actualmente ninguna cohorte ...