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In‐hospital and 1‐year mortality associated with diabetes in patients with acute heart failure: results from the ESC‐HFA Heart Failure Long‐Term Registry
dc.contributor.author | Targher, Giovanni | |
dc.contributor.author | Dauriz, Marco | |
dc.contributor.author | Laroche, Cecile | |
dc.contributor.author | Temporelli, Pier Luigi | |
dc.contributor.author | Hassanein, Mahmoud | |
dc.contributor.author | Seferovic, Petar M. | |
dc.contributor.author | Drozdz, Jaroslaw | |
dc.contributor.author | Ferrari, Roberto | |
dc.contributor.author | Anker, Stefan | |
dc.contributor.author | Coats, Andrew | |
dc.contributor.author | Filippatos, Gerasimos | |
dc.contributor.author | Crespo-Leiro, María Generosa | |
dc.contributor.author | Mebazaa, Alexandre | |
dc.contributor.author | Piepoli, Massimo F. | |
dc.contributor.author | Maggioni, Aldo P. | |
dc.contributor.author | Tavazzi, Luigi | |
dc.date.accessioned | 2019-03-12T12:40:39Z | |
dc.date.available | 2019-03-12T12:40:39Z | |
dc.date.issued | 2016-10-28 | |
dc.identifier.citation | Targher G, Dauriz M, Laroche C, et al. In‐hospital and 1‐year mortality associated with diabetes in patients with acute heart failure: results from the ESC‐HFA Heart Failure Long‐Term Registry. Eur J Heart Fail. 2017; 19(1): 54-65 | es_ES |
dc.identifier.issn | 1879-0844 | |
dc.identifier.uri | http://hdl.handle.net/2183/22184 | |
dc.description.abstract | [Abstract] AIMS: The aim of this study was to evaluate the in-hospital and 1-year prognostic impact of diabetes and elevated blood glucose levels at hospital admission in patients with acute heart failure (HF). METHODS AND RESULTS: We studied a multinational cohort of 6926 hospitalized patients with acute HF enrolled in the European Society of Cardiology (ESC) and Heart Failure Association (HFA) Long-Term Registry, of whom 49.4% (n = 3422) had known or previously undiagnosed diabetes (defined as self-reported history, or medication use, or fasting glucose levels ≥7.0 mmol/L or haemoglobin A1c ≥6.5%). Compared with those without diabetes, patients with known or previously undiagnosed diabetes had higher cumulative rates of in-hospital mortality, 1-year mortality, and 1-year HF re-hospitalization that occurred independently of multiple clinical risk factors: in-hospital mortality [6.8 vs. 4.4%; adjusted hazard ratio (HR) 1.774; 95% confidence interval (CI) 1.282-2.456, P < 0.001], 1-year all-cause mortality (27.5 vs. 24%; adjusted HR 1.162; 95% CI 1.020-1.325, P = 0.024), and 1-year hospital re-admissions for HF (23.2 vs. 18.5%; adjusted HR 1.320; 95% CI 1.139-1.530, P < 0.001). Moreover, elevated admission blood glucose concentrations were powerfully prognostic for in-hospital mortality, but not for 1-year mortality or re-hospitalizations, in both patients with and without diabetes. CONCLUSIONS: Among patients hospitalized for acute HF, the presence of diabetes is independently associated with an increased risk of in-hospital mortality, 1-year all-cause mortality, and 1-year re-hospitalizations for HF, underscoring the need for more effective and personalized treatments of diabetes in this particularly high-risk patient population. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Wiley | es_ES |
dc.relation.uri | https://doi.org/10.1002/ejhf.679 | es_ES |
dc.rights | Atribución-NoComercial-SinDerivadas 3.0 España | es_ES |
dc.rights | This is the peer reviewed version of the article which has been published in final form at Wiley Online Library. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for self-archiving. | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ | * |
dc.subject | Co-morbidities | es_ES |
dc.subject | Diabetes | es_ES |
dc.subject | Acute heart failure | es_ES |
dc.subject | Observational outcome study | es_ES |
dc.title | In‐hospital and 1‐year mortality associated with diabetes in patients with acute heart failure: results from the ESC‐HFA Heart Failure Long‐Term Registry | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.access | info:eu-repo/semantics/openAccess | es_ES |
UDC.journalTitle | European Journal of Heart Failure | es_ES |
UDC.volume | 19 | es_ES |
UDC.issue | 1 | es_ES |
UDC.startPage | 54 | es_ES |
UDC.endPage | 65 | es_ES |
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