Mitochondrial DNA haplogroup H as a risk factor for idiopathic dilated cardiomyopathy in Spanish population
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Mitochondrial DNA haplogroup H as a risk factor for idiopathic dilated cardiomyopathy in Spanish populationAutor(es)
Fecha
2013-03-23Cita bibliográfica
Fernández-Caggiano M, Barallobre-Barreiro J, Rego-Pérez I, et al. Mitochondrial DNA haplogroup H as a risk factor for idiopathic dilated cardiomyopathy in spanish population. Mitochondrion. 2013;13(4):263-268
Resumen
[Abstract] Idiopathic dilated cardiomyopathy (IDC) is a structural heart disease with strong genetic background. The different single nucleotide polymorphisms (SNPs) that constitute mitochondrial haplogroups could play an important role in IDC progression. The aim of this study was to test frequencies of mitochondrial haplogroups in healthy controls (n = 422) and IDC patients (n = 304) of a Caucasian Spanish population. To achieve this, ten major European haplogroups were identified. Frequencies and Odds Ratios for the association between IDC and haplogroups were calculated in both groups. We found that compared to healthy controls, the prevalence of haplogroup H was significantly higher in IDC patients (40.0% vs 50.7%, p-value = 0.040).
Palabras clave
Mitochondrial haplogroups
Idiopathic dilated cardiomyopathy
Oxidative stress
Reactive oxygen species
Single nucleotide polymorphisms
Idiopathic dilated cardiomyopathy
Oxidative stress
Reactive oxygen species
Single nucleotide polymorphisms
Versión del editor
Derechos
Atribución-NoComercial-SinDerivadas 3.0 España
ISSN
1567-7249
1872-8278
1872-8278