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dc.contributor.authorPérez-Belmonte, Luis M.
dc.contributor.authorMoreno-Santos, Inmaculada
dc.contributor.authorGómez Doblas, Juan José
dc.contributor.authorGarcía-Pinilla, José Manuel
dc.contributor.authorMorcillo-Hidalgo, Luis
dc.contributor.authorGarrido-Sánchez, Lourdes
dc.contributor.authorSantiago-Fernández, Concepción
dc.contributor.authorCrespo-Leiro, María Generosa
dc.contributor.authorCarrasco-Chinchilla, Fernando
dc.contributor.authorSánchez-Fernández, Pedro L.
dc.contributor.authorTeresa Galván, Eduardo de
dc.contributor.authorJiménez-Navarro, Manuel
dc.date.accessioned2017-08-28T07:51:26Z
dc.date.available2017-08-28T07:51:26Z
dc.date.issued2017-07-20
dc.identifier.citationPérez-Belmonte LM, Moreno-Santos I, Gómez-Doblas JJ, et al. Expression of epicardial adipose tissue thermogenic genes in patients with reduced and preserved ejection fraction heart failure. Int J Med Sci [Internet]. 2017 Jul 20 [acceso 2017 Ago 28]; 14(9): 891-895. Disponible en: http://www.medsci.org/v14p0891.htmes_ES
dc.identifier.issn1449-1907
dc.identifier.urihttp://hdl.handle.net/2183/19360
dc.description.abstract[Abstract] Epicardial adipose tissue has been proposed to participate in the pathogenesis of heart failure. The aim of our study was to assess the expression of thermogenic genes (Uncoupling protein 1 (UCP1), peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC1α), and PR-domain-missing 16 (PRDM16) in epicardial adipose tissue in patients with heart failure, stablishing the difference according to left ventricular ejection fraction (reduced or preserved). Among the 75 patients in our study, 42.7% (n=32) had reduced left ventricular ejection fraction. UCP1, PGC1α and PRDM16 mRNA in EAT were significantly lower in patients with reduced left ventricular ejection fraction. Multiple regression analysis showed that age, male gender, body max index, presence of obesity, type-2-diabetes mellitus, hypertension and coronary artery disease and left ventricular ejection fraction were associated with the expression levels of UCP1, PGC1α and PRDM16 mRNA. Thermogenic genes expressions in epicardial adipose tissue (UCP1: OR 0.617, 95%CI 0.103-0.989, p=0.042; PGC1α: OR 0.416, 95%CI 0.171-0.912, p=0.031; PRDM16: OR 0.643, 95%CI 0.116-0.997, p=0.044) were showed as protective factors against the presence of heart failure with reduced left ventricular ejection fraction, and age (OR 1.643, 95%CI 1.001-3.143, p=0.026), presence of coronary artery disease (OR 6.743, 95%CI 1.932-15.301, p<0.001) and type-2-diabetes mellitus (OR 4.031, 95%CI 1.099-7.231, p<0.001) were associated as risk factors. The adequate expression of thermogenic genes has been shown as possible protective factors against heart failure with reduced ejection fraction, suggesting that a loss of functional epicardial adipose tissue brown-like features would participate in a deleterious manner on heart metabolism. Thermogenic genes could represent a future novel therapeutic target in heart failure.es_ES
dc.description.sponsorshipMinisterio de Salud, Servicios Sociales e Igualdad; PI13/02542es_ES
dc.description.sponsorshipMinisterio de Salud, Servicios Sociales e Igualdad; PI11/01661es_ES
dc.description.sponsorshipRed de Investigación Cardiovascular (España), RD12/0042/0030es_ES
dc.language.isoenges_ES
dc.publisherIvyspringes_ES
dc.relation.urihttp://dx.doi.org/10.7150/ijms.19854es_ES
dc.rightsAtribución 3.0 Españaes_ES
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.subjectEpicardial adipose tissuees_ES
dc.subjectHeart failurees_ES
dc.subjectLeft ventricular ejection fractiones_ES
dc.subjectThermogenic geneses_ES
dc.titleExpression of epicardial adipose tissue thermogenic genes in patients with reduced and preserved ejection fraction heart failurees_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.accessinfo:eu-repo/semantics/openAccesses_ES
UDC.journalTitleInternational Journal of Medical Scienceses_ES
UDC.volume14es_ES
UDC.issue9es_ES
UDC.startPage891es_ES
UDC.endPage895es_ES


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