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dc.contributor.authorÁlvarez-Álvarez, Rolando J.
dc.contributor.authorBarge-Caballero, Eduardo
dc.contributor.authorChávez-Leal, Sergio
dc.contributor.authorPaniagua-Martín, María J.
dc.contributor.authorMarzoa Rivas, Raquel
dc.contributor.authorBarbeito Caamaño, Cayetana
dc.contributor.authorLópez-Sainz, A.
dc.contributor.authorGrille Cancela, Zulaika
dc.contributor.authorBlanco-Canosa, Paula
dc.contributor.authorHerrera-Noreña, José M.
dc.contributor.authorCuenca-Castillo, José J.
dc.contributor.authorCastro-Beiras, Alfonso
dc.contributor.authorCrespo-Leiro, María Generosa
dc.date.accessioned2017-06-20T10:44:19Z
dc.date.available2017-06-20T10:44:19Z
dc.date.issued2015-10-02
dc.identifier.citationÁlvarez-Álvarez R, Barge-Caballero E, Chávez-Leal SA, et al. Venous thromboembolism in heart transplant recipients: Incidence, recurrence and predisposing factors. J Heart Lung Transpl. 2015;34(2):167-174es_ES
dc.identifier.issn1053-2498
dc.identifier.issn1557-3117
dc.identifier.urihttp://hdl.handle.net/2183/19189
dc.description.abstract[Abstract] Background. A high frequency of venous thromboembolism (VTE) has been observed after lung, kidney, and liver transplantation. However, data about the incidence of this complication among heart transplant (HT) recipients are lacking. Methods. We analyzed the incidence, recurrence, and predisposing factors of VTE in a single-center cohort of 635 patients who underwent HT from April 1991 to April 2013. Deep venous thrombosis (DVT) and pulmonary embolism (PE) were considered as VTE episodes. Results. During a median post-transplant follow-up of 8.4 years, 62 VTE episodes occurred in 54 patients (8.5%). Incidence rates of VTE, DVT, and PE were, respectively, 12.7 (95% confidence interval [CI], 9.7–16.3), 8.4 (95% CI, 6.0–11.4), and 7.0 (95% CI 4.8–9.7) episodes per 1,000 patient-years. Incidence rates of VTE during the first post-transplant year and beyond were, respectively, 45.1 (95% CI, 28.9–67.1) and 8.7 (95% CI 6.2–11.2) episodes per 1,000 patient-years. The incidence rate of VTE recurrence after a first VTE episode was 30.5 (95% CI, 13.2–60.2) episodes per 1,000 patient-years. By means of multivariable Cox regression, chronic renal dysfunction, older age, obesity, and the use of mammalian target of rapamycin inhibitors were identified as independent risk factors for VTE among HT recipients. Conclusions. VTE is a frequent complication after HT, mainly during the first post-operative year. In view of a high recurrence rate, long-term anti-coagulation should be considered in HT recipients who experience a first VTE episode.es_ES
dc.language.isoenges_ES
dc.publisherElsevier para International Society for Heart and Lung Transplantationes_ES
dc.relation.urihttp://dx.doi.org/10.1016/j.healun.2014.09.039es_ES
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 Españaes_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/*
dc.subjectHeart transplantationes_ES
dc.subjectThromboembolismes_ES
dc.subjectDeep venous thrombosises_ES
dc.subjectPulmonary embolismes_ES
dc.titleVenous thromboembolism in heart transplant recipients: Incidence, recurrence and predisposing factorses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.accessinfo:eu-repo/semantics/openAccesses_ES
UDC.journalTitleThe Journal of Heart and Lung Transplantationes_ES
UDC.volume34es_ES
UDC.issue2es_ES
UDC.startPage167es_ES
UDC.endPage174es_ES


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