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Mostrando ítems 1-10 de 21
New insights into molecular mechanisms of sunitinib-associated side effects
(American Association for Cancer Research, 2011-12)
[Abstract] The introduction of targeted therapy represents a major advance in the treatment of tumor progression. Targeted agents are a novel therapeutic approach developed to disrupt different cellular signaling pathways. ...
Fructose transporter Glut5 expression in clear renal cell carcinoma
(Spandidos, 2010-12-10)
[Abstract] Renal cell carcinomas (RCC) can be subclassified for general purposes into clear cell, papillary cell, chromophobe cell carcinomas and oncocytomas. Other tumours such as collecting duct, medullary, mucinous ...
Hakai reduces cell-substratum adhesion and increases epithelial cell invasion
(BioMed Central, 2011-11-03)
[Abstract]
Background. The dynamic regulation of cell-cell adhesions is crucial for developmental processes, including tissue formation, differentiation and motility. Adherens junctions are important components of the ...
Role of the microtubule-targeting drug vinflunine on cell-cell adhesions in bladder epithelial tumour cells
(BioMed Central, 2014-07-10)
[Abstract]
Background. Vinflunine (VFL) is a microtubule-targeting drug that suppresses microtubule dynamics, showing anti-metastatic properties both in vitro and in living cancer cells. An increasing body of evidence ...
Multiple biomarker tissue arrays: a computational approach to identifying protein-protein interactions in the EGFR/ERK signalling pathway
(BioMed Central, 2012-09-01)
[Abstract]
Background. Many studies have demonstrated genetic and environmental factors that lead to renal cell carcinoma (RCC) and that occur during a protracted period of tumourigenesis. It appears suitable to identify ...
Sunitinib-induced asthenia: from molecular basis to clinical relief
(Taylor & Francis, 2011-11-01)
[Abstract] Asthenia-fatigue syndrome (AFS) is defined as a persistent, subjective sense of tiredness related to cancer or its treatment and greatly impacts quality of life among cancer patients. All tyrosine kinase inhibitors, ...
Biological influence of Hakai in cancer: a 10-year review
(Springer, 2012-02-19)
[Abstract] In order to metastasize, cancer cells must first detach from the primary tumor, migrate, invade through tissues, and attach to a second site. Hakai was discovered as an E3 ubiquitin-ligase that mediates the ...
Potential role of sugar transporters in cancer and their relationship with anticancer therapy
(Hindawi, 2010-06-20)
[Abstract] Sugars, primarily glucose and fructose, are the main energy source of cells. Because of their hydrophilic nature, cells use a number of transporter proteins to introduce sugars through their plasma membrane. ...
miR-203 regulates cell proliferation through Its influence on Hakai expression
(PLoS, 2012-12-20)
Gene expression is potently regulated through the action of microRNAs (miRNAs). Here, we present evidence of a miRNA regulating Hakai protein. Hakai was discovered as an E3 ubiquitin-ligase that mediates the posttranslational ...
Clinical implications of epithelial cell plasticity in cancer progression
(Elsevier, 2015)
[Abstract] In the last few years, the role of epithelial cell plasticity in cancer biology research has gained increasing attention. This concept refers to the ability of the epithelial cells to dynamically switch between ...
