Listar INIBIC-OCT - Artigos por autor "Blanco, Moisés"
Mostrando ítems 1-12 de 12
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A new scenario in metastatic renal cell carcinoma: a SOG‑GU consensus
Vázquez Estévez, Sergio; Anido Herranz, Urbano; Lázaro Quintela, Martín; Fernández Calvo, Ovidio; Fernández-Núñez, Natalia; Dios Álvarez, N. de; Varela, V.; Campos Balea, B.; Agraso, S.; Areses, M. C.; Iglesias, L.; Blanco, Moisés; Maciá, S.; Antón-Aparicio, Luis M. (Springer, 2020-02-15)[Abstract] Background This article describes and compares approved targeted therapies and the newer immunotherapy agents. Materials and methods This article especially performs an in-depth review of currently available ... -
A novel procedure for protein extraction from formalin-fixed paraffin-embedded tissues
Rodríguez-Rigueiro, Teresa; Valladares-Ayerbes, Manuel; Haz, Mar; Blanco, Moisés; Aparicio Gallego, Guadalupe; Fernández-Puente, Patricia; Blanco García, Francisco J; Lorenzo-Patiño, María J.; Antón-Aparicio, Luis M.; Figueroa, Angélica (Wiley, 2011-05-18)[Abstract] Most of the archived pathological specimens in hospitals are kept as formalin-fixed paraffin-embedded tissues (FFPE) for long-term preservation. Up to now, these samples are only used for immunohistochemistry ... -
Biological influence of Hakai in cancer: a 10-year review
Antón-Aparicio, Luis M.; Valladares-Ayerbes, Manuel; Blanco, Moisés; Alonso, Guillermo; Figueroa, Angélica (Springer, 2012-02-19)[Abstract] In order to metastasize, cancer cells must first detach from the primary tumor, migrate, invade through tissues, and attach to a second site. Hakai was discovered as an E3 ubiquitin-ligase that mediates the ... -
Circulating levels of GDF15, MMP7 and miR-200c as a poor prognostic signature in gastric cancer
Blanco, Moisés; Tarrío, Nuria; Reboredo, Margarita; Haz, Mar; García, Jorge; Quindós-Varela, María; Figueroa, Angélica; Antón-Aparicio, Luis M.; Calvo, Lourdes; Valladares-Ayerbes, Manuel (Future Science, 2014-06-20)[Abstract] Aim: To analyze GDF15 and MMP7 serum levels as diagnostic biomarkers in gastric cancer (GC) patients. The prognostic value of GDF15 and MMP7 serum levels in combination with miR-200c blood expression was also ... -
Circulating microRNAs: molecular microsensors in gastrointestinal cancer
Blanco, Moisés; Calvo, Lourdes; Figueroa, Angélica; Haz, Mar; Antón-Aparicio, Luis M.; Valladares-Ayerbes, Manuel (MPDI, 2012-07-09)[Abstract] MicroRNAs (miRNAs) are small molecules of single strand non-coding RNAs, which are able to regulate gene expression. miRNAs have been involved in multiple cellular processes, such as proliferation, apoptosis and ... -
Circulating miR-200c and miR-141 and outcomes in patients with breast cancer
Antolín, Silvia; Calvo, Lourdes; Blanco, Moisés; Paz Santiago, María; Lorenzo-Patiño, María J.; Haz, Mar; Santamarina, Isabel; Figueroa, Angélica; Antón-Aparicio, Luis M.; Valladares-Ayerbes, Manuel (BioMed Central, 2015)[Abstract] Background. The deregulation of microRNAs in both tumours and blood has led to the search for microRNAs to indicate the presence of cancer and predict prognosis. We hypothesize the deregulation of miR-200c/miR-141 ... -
Circulating miR-200c as a diagnostic and prognostic biomarker for gastric cancer
Valladares-Ayerbes, Manuel; Reboredo, Margarita; Medina Villaamil, Vanessa; Iglesias-Díaz, Pilar; Lorenzo-Patiño, María J.; Haz, Mar; Santamarina, Isabel; Blanco, Moisés; Fernández-Tajes, Juan; Quindós-Varela, María; Carral, Alberto; Figueroa, Angélica; Antón-Aparicio, Luis M.; Calvo, Lourdes (BioMed Central, 2012-09-06)[Abstract] Background. MicroRNAs are aberrantly expressed and correlate with tumourigenesis and the progression of solid tumours. The miR-200 family determines the epithelial phenotype of cancer cells and regulates ... -
Clinical implications of epithelial cell plasticity in cancer progression
Antón-Aparicio, Luis M.; Blanco, Moisés; Castosa, Raquel; Concha, Ángel; Valladares-Ayerbes, Manuel; Calvo, Lourdes; Figueroa, Angélica (Elsevier, 2015)[Abstract] In the last few years, the role of epithelial cell plasticity in cancer biology research has gained increasing attention. This concept refers to the ability of the epithelial cells to dynamically switch between ... -
miR-203 regulates cell proliferation through Its influence on Hakai expression
Abella Cajigal, Vanessa; Valladares-Ayerbes, Manuel; Rodríguez, Teresa; Haz, Mar; Blanco, Moisés; Tarrío, Nuria; Iglesias, Pilar; Antón-Aparicio, Luis M.; Figueroa, Angélica (PLoS, 2012-12-20)Gene expression is potently regulated through the action of microRNAs (miRNAs). Here, we present evidence of a miRNA regulating Hakai protein. Hakai was discovered as an E3 ubiquitin-ligase that mediates the posttranslational ... -
New insights into molecular mechanisms of sunitinib-associated side effects
Aparicio Gallego, Guadalupe; Blanco, Moisés; Figueroa, Angélica; García-Campelo, Rosario; Valladares-Ayerbes, Manuel; Grande Pulido, Enrique; Antón-Aparicio, Luis M. (American Association for Cancer Research, 2011-12)[Abstract] The introduction of targeted therapy represents a major advance in the treatment of tumor progression. Targeted agents are a novel therapeutic approach developed to disrupt different cellular signaling pathways. ... -
Potential role of sugar transporters in cancer and their relationship with anticancer therapy
Blanco, Moisés; Figueroa, Angélica; Grande Pulido, Enrique; García Campelo, Rosario; Antón-Aparicio, Luis M. (Hindawi, 2010-06-20)[Abstract] Sugars, primarily glucose and fructose, are the main energy source of cells. Because of their hydrophilic nature, cells use a number of transporter proteins to introduce sugars through their plasma membrane. ... -
Role of the microtubule-targeting drug vinflunine on cell-cell adhesions in bladder epithelial tumour cells
Antón-Aparicio, Luis M.; Castosa, Raquel; Haz, Mar; Rodríguez, Marta; Blanco, Moisés; Valladares-Ayerbes, Manuel; Figueroa, Angélica (BioMed Central, 2014-07-10)[Abstract] Background. Vinflunine (VFL) is a microtubule-targeting drug that suppresses microtubule dynamics, showing anti-metastatic properties both in vitro and in living cancer cells. An increasing body of evidence ...