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dc.contributor.authorBolós Fernández, Victoria
dc.contributor.authorMedina Villaamil, Vanessa
dc.contributor.authorAparicio Gallego, Guadalupe
dc.contributor.authorDíaz-Prado, Silvia
dc.contributor.authorGrande Pulido, Enrique
dc.date.accessioned2017-02-03T13:16:39Z
dc.date.available2017-02-03T13:16:39Z
dc.date.issued2009
dc.identifier.citationBolós V, Blanco M, Medina V, Aparicio G, Díaz-Prado S, Grande E. Notch signalling in cancer stem cells. Clin Transl Oncol. 2009;11(1):11-19es_ES
dc.identifier.issn1699-048X
dc.identifier.issn1699-3055
dc.identifier.urihttp://hdl.handle.net/2183/18049
dc.description.abstract[Abstract] A new theory about the development of solid tumours is emerging from the idea that solid tumours, like normal adult tissues, contain stem cells (called cancer stem cells) and arise from them. Genetic mutations encoding for proteins involved in critical signalling pathways for stem cells such as BMP, Notch, Hedgehog and Wnt would allow stem cells to undergo uncontrolled proliferation and form tumours. Taking into account that cancer stem cells (CSCs) would represent the real driving force behind tumour growth and that they may be drug resistant, new agents that target the above signalling pathways could be more effective than current anti-solid tumour therapies. In the present paper we will review the molecular basis of the Notch signalling pathway. Additionally, we will pay attention to their role in adult stem cell self-renewal, and cell fate specification and differentiation, and we will also review evidence that supports their implication in cancer.es_ES
dc.language.isoenges_ES
dc.publisherSpringeres_ES
dc.relation.urihttp://dx.doi.org/10.1007/s12094-009-0305-2es_ES
dc.rightsThe final publication is avaliable at Srpinger Linkes_ES
dc.subjectNotch pathwayes_ES
dc.subjectCancer stem cellses_ES
dc.titleNotch signalling in cancer stem cellses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.accessinfo:eu-repo/semantics/openAccesses_ES
UDC.journalTitleClinical and Translational Oncologyes_ES
UDC.volume11es_ES
UDC.issue1es_ES
UDC.startPage11es_ES
UDC.endPage19es_ES


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