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dc.contributor.authorDíaz-Prado, Silvia
dc.contributor.authorMedina Villaamil, Vanessa
dc.contributor.authorAparicio Gallego, Guadalupe
dc.contributor.authorBlanco, Moisés
dc.contributor.authorLópez Cedrún, José Luis
dc.contributor.authorSironvalle Soliva, Sheila
dc.contributor.authorValladares-Ayerbes, Manuel
dc.contributor.authorGarcía Campelo, Rosario
dc.contributor.authorAntón-Aparicio, Luis M.
dc.date.accessioned2016-11-14T11:52:38Z
dc.date.available2016-11-14T11:52:38Z
dc.date.issued2009
dc.identifier.citationDíaz Prado S, Medina Villamil V, Aparicio Gallego G, Blanco Calvo M, López Cedrún JL, Sironvalle Soliva S, et al. Expression of Wnt gene family and frizzled receptors in head and neck squamous cell carcinomas. Virchows Archiv. 2009;455(1):67-75.es_ES
dc.identifier.issn0945-6317
dc.identifier.issn1432-2307
dc.identifier.urihttp://hdl.handle.net/2183/17557
dc.description.abstract[Abstract] Genes of the Wnt and Frizzled class, expressed in HNSCC tissue and cell lines, have an established role in cell morphogenesis and differentiation, and also they have oncogenic properties. We studied Wnt and Fz genes as potential tumor-associated markers in HNSCC by qPCR. Expression levels of Wnt and Fz genes in 22 unique frozen samples from HNSCC were measured. We also assessed possible correlation between the expression levels obtained in cancer samples in relation to clinicopathologic outcome. Wnt-1 was not expressed in the majority of the HNSCC studied, whereas Wnt-5A was the most strongly expressed by the malignant tumors. Wnt-10B expression levels were related with higher grade of undifferentiation. Related to Fz genes, Fz-5 showed more expression levels in no-affectation of regional lymph nodes. Kaplan–Meier survival analyses suggest a reduced time of survival for low and high expression of Wnt-7A and Fz-5 mRNA, respectively. qPCR demonstrated that HNSCC express Wnt and Fz members, and suggested that Wnt and Fz signaling is activated in HNSCC cells.es_ES
dc.language.isoenges_ES
dc.publisherSpirngeres_ES
dc.relation.urihttp://dx.doi.org/10.1007/s00428-009-0793-zes_ES
dc.rightsThe final publication is avaliable at Springer Linkes_ES
dc.subjectWntes_ES
dc.subjectFrizzledes_ES
dc.subjectHead and neck squamous cell carcinomaes_ES
dc.subjectQuantitative real-time PCRes_ES
dc.subjectMolecular markeres_ES
dc.titleExpression of Wnt gene family and frizzled receptors in head and neck squamous cell carcinomases_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.accessinfo:eu-repo/semantics/openAccesses_ES
UDC.journalTitleVirchows Archives_ES
UDC.volume455es_ES
UDC.issue1es_ES
UDC.startPage67es_ES
UDC.endPage75es_ES


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