• Advanced heart failure: a position statement of the Heart Failure Association of the European Society of Cardiology 

      Crespo-Leiro, María Generosa; Metra, Marco; Lund, Lars H.; Milicic, Davor; Costanzo, Maria Rosa; Filippatos, Gerasimos; Gustafsson, Finn; Tsui, Steven; Barge-Caballero, Eduardo; De Jonge, Nicolaas; Frigerio, Maria; Hamdan, Righab; Hasin, Tal; Hülsmann, Martin; Nalbantgil, Sanem; Potena, Luciano; Bauersachs, Johann; Gkouziouta, Aggeliki; Ruhparwar, Arjang; Ristic, A.D.; Straburzynska-Migaj, Ewa; McDonagh, Theresa; Seferovic, Petar M.; Ruschitzka, Frank (Wiley, 2018-05-27)
      [Abstract] This article updates the Heart Failure Association of the European Society of Cardiology (ESC) 2007 classification of advanced heart failure and describes new diagnostic and treatment options for these patients. ...
    • Advanced heart failure: definition, epidemiology, and clinical course 

      Crespo-Leiro, María Generosa; Barge-Caballero, Eduardo (Elsevier, 2021-07-15)
      [Abstract] Advanced heart failure (HF) is characterized by a progressive worsening of symptoms disabling for daily life, refractory to all therapies, and with high mortality. These patients may be candidates for life-prolonging ...
    • Assessing the relationship between molecular rejection and parenchymal injury in heart transplant biopsies 

      Madill-Thomsen, Katelynn S.; Reeve, Jeff; Aliabadi-Zuckermann, Arezu; Cadeiras, Martin; Crespo-Leiro, María Generosa; Depasquale, Eugene D.; Deng, Mario; Goeckler, Johannes; Kim, Daniel H.; Kobashigawa, Jon; MacDonald, Peter; Potena, Luciano; Shah, Keyur; Stehlik, Josef; Zuckermann, Andreas; Halloran, Philip F. (Wolters Kluwer, 2022-11)
      [Abstract] Background: The INTERHEART study (ClinicalTrials.gov #NCT02670408) used genome-wide microarrays to detect rejection in endomyocardial biopsies; however, many heart transplants with no rejection have late dysfunction ...
    • Chronic renal dysfunction in maintenance heart transplant patients: the ICEBERG study 

      González-Vílchez, Francisco; Arizón-del-Prado, José M.; Segovia-Cubero, Javier; Almenar-Bonet, Luis; Crespo-Leiro, María Generosa; Palomo, Jesús; Delgado Jiménez, Juan Francisco; Mirabet, Sonia; Rábago, Gregorio; Pérez-Villa, Félix; Díaz, Beatriz; Sanz, M.L.; Pascual, Domingo; Fuente, Luis de la; Guinea, G. (Elsevier, 2014-02-05)
      [Abstract] Chronic renal dysfunction (CRD) is a major complication after heart transplantation. We sought to describe the renal function over time, to assess the risk factors associated with CRD development, and to evaluate ...
    • Circulating miR-181a-5p as a New Biomarker for Acute Cellular Rejection in Heart Transplantation 

      Constanso-Conde, Ignacio; Hermida-Prieto, Manuel; Barge-Caballero, Eduardo; Núñez, Lucía; Pombo-Otero, Jorge; Suárez-Fuentetaja, Natalia; Paniagua-Martín, María J.; Barge-Caballero, Gonzalo; Couto-Mallón, David; Pan Lizcano, Ricardo Francisco; Vázquez Rodríguez, José Manuel; Crespo-Leiro, María Generosa (Elsevier, 2020-06-07)
      [Abstract] Background: Acute cellular rejection (ACR) is a major complication in heart transplantation (HTx). Endomyocardial biopsy is the reference method for early detection of ACR, but a new non-invasive approach is ...
    • Clinical evaluation of rosuvastatin in heart transplant patients with hypercholesterolemia and therapeutic failure of other statin regimens: short-term and long-term efficacy and safety results 

      Barge-Caballero, Gonzalo; Barge-Caballero, Eduardo; Marzoa Rivas, Raquel; Paniagua-Martín, María J.; Barrio-Rodríguez, Alfredo; Naya, Carmen; Blanco-Canosa, Paula; Grille Cancela, Zulaika; Vázquez Rodríguez, José Manuel; Crespo-Leiro, María Generosa (Wiley, 2015-04-23)
      [Abstract] We conducted an observational study of 30 heart transplant recipients with serum low-density lipoprotein cholesterol (LDL-c) >100 mg/dl despite previous statin therapy, who were treated with rosuvastatin 10 mg ...
    • Epidemiological study of tricuspid regurgitation after cardiac transplantation: does it influence survival? 

      López-Vilella, Raquel; Paniagua-Martín, María J.; González-Vílchez, Francisco; Donoso Trenado, Víctor; Barge-Caballero, Eduardo; Sánchez-Lázaro, Ignacio; Aller Fernández, Ana Vanesa; Martínez-Dolz, Luis; Crespo-Leiro, María Generosa; Almenar-Bonet, Luis (Frontiers, 2022-03-21)
      [Abstract] Background: Tricuspid valve disease is the most frequent valvulopathy after heart transplantation (HTx). Evidence for the negative effect of post-transplant tricuspid regurgitation (TR) on survival is contradictory. ...
    • Evaluation of humoral immunity profiles to identify heart recipients at risk for development of severe infections: a multicenter prospective study 

      Sarmiento, Elizabeth; Jaramillo, María; Calahorra, Leticia; Fernández-Yáñez, Juan; Gómez-Sánchez, Miguel; Crespo-Leiro, María Generosa; Paniagua-Martín, María J.; Almenar-Bonet, Luis; Cebrián, Mónica; Rábago, Gregorio; Levy, Beltrán; Segovia-Cubero, Javier; Gómez-Bueno, Manuel; López, Javier; Mirabet, Sonia; Navarro, Joaquín; Rodríguez-Molina, Juan José; Fernández-Cruz, Eduardo; Carbone, Javier (Elsevier, 2017)
      [Abstract] BACKGROUND: New biomarkers are necessary to improve detection of the risk of infection in heart transplantation. We performed a multicenter study to evaluate humoral immunity profiles that could better enable ...
    • Health‐related quality of life, social support, and caregiver burden between six and 120 months after heart transplantation: a Spanish multicenter cross‐sectional study 

      Delgado Jiménez, Juan Francisco; Almenar-Bonet, Luis; González-Vílchez, Francisco; Arizón-del-Prado, José M.; Gómez-Bueno, Manuel; De la Fuente-Galán, Luis; Brossa-Loidi, Vicens; Fernández-Yáñez, Juan; Díaz Molina, Beatriz; Pascual Figal, Domingo A.; Lage-Gallé, Ernesto; Sanz-Julve, Marisa; Manito-Lorite, Nicolás; Crespo-Leiro, María Generosa (Wiley, 2015-06-15)
      [Abstract] A multicenter cross-sectional study was conducted to determine the current heart transplant (HTx) outcomes in Spain. Clinical and functional status, health-related quality of life (HRQoL), social support, and ...
    • Heart transplantation: focus on donor recovery strategies, left ventricular assist devices, and novel therapies 

      Crespo-Leiro, María Generosa; Costanzo, María Rosa; Gustafsson, Finn; Khush, Kiran K.; Macdonald, Peter S.; Potena, Luciano; Stehlik, Josef; Zuckermann, Andreas; Mehra, Mandeep R. (Oxford Academic, 2022-06-14)
      [Abstract] Heart transplantation is advocated in selected patients with advanced heart failure in the absence of contraindications. Principal challenges in heart transplantation centre around an insufficient and underutilized ...
    • In-hospital postoperative infection after heart transplantation: risk factors and development of a novel predictive score 

      Fernández-Ugidos, Paula; Barge-Caballero, Eduardo; Gómez-López, Rocío; Paniagua-Martín, María J.; Barge-Caballero, Gonzalo; Couto-Mallón, David; Solla-Buceta, Miguel; Iglesias-Gil, Carmen; Aller-Fernández, Vanesa; González-Barbeito, Miguel; Vázquez Rodríguez, José Manuel; Crespo-Leiro, María Generosa (Wiley, 2019-05-11)
      [Abstract] Introduction: Infection is one of the most significant complications following heart transplantation (HT). The aim of this study was to identify specific risk factors for early postoperative infections in HT ...
    • Incidence and prognosis of colorectal cancer after heart transplantation: data from the spanish post-heart transplant tumor registry 

      Sagastagoitia-Fornie, Marta; Morán-Fernández, Laura; Blázquez-Bermejo, Zorba; Díaz-Molina, Beatriz; Gómez-Bueno, Manuel; Almenar-Bonet, Luis; López Granados, Amador; González-Vílchez, Francisco; Mirabet-Pérez, Sonia; García-Romero, Elena; Sobrino-Márquez, José Manuel; Rábago Juan-Aracil, Gregorio; Castel-Lavilla, María Ángeles; Blasco-Peiró, Teresa; Garrido-Bravo, Iris P.; De la Fuente-Galán, Luis; Muñiz, Javier; Crespo-Leiro, María Generosa (Frontiers, 2023-05)
      [Abstract] In this observational and multicenter study, that included all patients who underwent a heart transplantation (HT) in Spain from 1984 to 2018, we analyzed the incidence, management, and prognosis of colorectal ...
    • Indications, complications, and outcomes of cardiac surgery after heart transplantation: results from the cash study 

      Gökler, Johannes; Aliabadi-Zuckermann, Arezu Z.; Kaider, Alexandra; Ambardekar, Amrut V.; Antretter, Herwig; Artemiou, Panagiotis; Bertolotti, Alejandro M.; Boeken, Udo; Brossa, Vicens; Copeland, Hannah; Crespo-Leiro, María Generosa; Eixeré-Esteve, Andrea; Epailly, Eric; Farag, Mina; Hulman, Michal; Khush, Kiran K.; Masetti, Marco; Patel, Jignesh; Ross, Heather J.; Rudez, Igor; Silvestry, Scott; Martín Suárez, Sofía; Vest, Amanda; Zuckermann, Andreas O. (Frontiers, 2022-06-09)
      [Abstract] Background: Allograft pathologies, such as valvular, coronary artery, or aortic disease, may occur early and late after cardiac transplantation. Cardiac surgery after heart transplantation (CASH) may be an option ...
    • Malignancy following heart transplantation: differences in incidence and prognosis between sexes – a multicenter cohort study 

      Minguito‐Carazo, Carlos; Gómez-Bueno, Manuel; Almenar‐Bonet, Luis; Barge-Caballero, Eduardo; González-Vílchez, Francisco; Delgado-Jiménez, Juan F.; Arizón-del-Prado, José M.; Sousa-Casasnovas, Iago; Mirabet, Sonia; González-Costello, José; Sobrino-Márquez, José Manuel; Pérez-Villa, Félix; Díaz Molina, Beatriz; Rábago, Gregorio; Blasco-Peiró, Teresa; De la Fuente-Galán, Luis; Garrido-Bravo, Iris P.; García-Guereta, Luis; Camino, Manuela; Albert-Brotons, Dimpna C.; Muñiz, Javier; Crespo-Leiro, María Generosa (Wiley Online Library, 2021-03-12)
      [Abstract] Male patients are at increased risk for developing malignancy postheart transplantation (HT); however, real incidence and prognosis in both genders remain unknown. The aim of this study was to assess differences ...
    • Polymorphisms in genes related to the complement system and antibody-mediated cardiac allograft rejection 

      Marrón Liñares, Grecia Manuela; Núñez, Lucía; Crespo-Leiro, María Generosa; Barge-Caballero, Eduardo; Pombo-Otero, Jorge; Paniagua-Martín, María J.; Suárez-Fuentetaja, Natalia; Cid, Javier; Grille Cancela, Zulaika; Muñiz, Javier; Tan, Carmela D.; Rene Rodríguez, E.; Vázquez Rodríguez, José Manuel; Hermida-Prieto, Manuel (Elsevier, 2017-07-15)
      [Abstract] Background. Heart transplantation (HT) is a life-saving treatment for patients with end-stage heart failure. One of the main problems after HT is the humoral response termed antibody-mediated rejection (AMR). ...
    • Preoperative toxoplasma gondii serostatus does not affect long-term survival of cardiac transplant recipients: analysis of the Spanish Heart Transplantation Registry 

      Barge-Caballero, Eduardo; Almenar-Bonet, Luis; Crespo-Leiro, María Generosa; Brossa-Loidi, Vicens; Rangel-Sousa, Diego; Gómez-Bueno, Manuel; Farrero-Torres, Marta; Díaz-Molina, Beatriz; Delgado-Jiménez, Juan F.; Martínez-Sellés, Manuel; López-Granados, Amador; De la Fuente-Galán, Luis; González-Costello, José; Garrido-Bravo, Iris P.; Blasco-Peiró, Teresa; Rábago, Gregorio; González-Vílchez, Francisco (Elsevier, 2017-10-07)
      [Abstract] Background. It's unclear whether pre-transplant T. gondii seropositivity is associated with impaired survival in heart transplant recipients. Objectives. To test the above-mentioned hypothesis in the Spanish ...
    • Prevalence and correlates of cost-related medication nonadherence to immunosuppressive drugs after heart transplantation: the international multicenter cross-sectional bright study 

      Schönfeld, Sandra; Denhaerynck, Kris; Berben, Lut; Dobbels, Fabienne; Russell, Cynthia L.; Crespo-Leiro, María Generosa; De Geest, Sabina (Wolters Kluwer, 2020)
      [Abstract] Background: Cost-related medication nonadherence (CRMNA) refers to not taking medications as prescribed because of difficulties paying for them. Objectives: The aims of this study were (1) to assess the ...
    • Registro Español de Trasplante Cardiaco. XXVII: Informe Oficial de la Sección de Insuficiencia Cardiaca y Trasplante Cardiaco de la Sociedad Española de Cardiología (1984-2015) 

      González-Vílchez, Francisco; Segovia-Cubero, Javier; Almenar-Bonet, Luis; Crespo-Leiro, María Generosa; Arizón-del-Prado, José M.; Sousa-Casasnovas, Iago; Delgado-Jiménez, Juan F.; Roig, Eulàlia; Sobrino, José Manuel; González-Costello, José (Elsevier, 2016-10-01)
      [Resumen] Introducción y objetivos. Se presentan las características y los resultados del trasplante cardiaco en España desde que empezó su actividad en mayo de 1984. Métodos. Se realiza un análisis descriptivo de las ...
    • Spanish Heart Transplantation Registry. 27th Official Report of the Spanish Society of Cardiology Working Group on Heart Failure and Heart Transplantation (1984-2015) 

      González-Vílchez, Francisco; Segovia-Cubero, Javier; Almenar, Luis; Crespo-Leiro, María Generosa; Arizón-del-Prado, José M.; Sousa-Casasnovas, Iago; Delgado-Jiménez, Juan F.; Roig, Eulàlia; Sobrino, José Manuel; González-Costello, José (Elsevier para Sociedad Española de Cardiología, 2016-10-01)
      [Abstract] Introduction and objectives. The present article reports the characteristics and results of heart transplants in Spain since this therapeutic modality was first used in May 1984. Methods. We describe the main ...
    • Temporal trends in the use and outcomes of temporary mechanical circulatory support as a bridge to cardiac transplantation in Spain. Final report of the ASIS-TC study 

      Barge-Caballero, Eduardo; González-Vílchez, Francisco; Almenar-Bonet, Luis; García-Cosío, María Dolores; González-Costello, José; Gómez-Bueno, Manuel; Castel-Lavilla, María Ángeles; Lambert-Rodríguez, José Luis; Martínez-Sellés, Manuel; Mirabet-Pérez, Sonia; De la Fuente-Galán, Luis; Hervás-Sotomayor, Daniela; Rangel-Sousa, Diego; Garrido-Bravo, Iris P.; Blasco-Peiró, Teresa; Rábago Juan-Aracil, Gregorio; Muñiz, Javier; Crespo-Leiro, María Generosa (Elsevier, 2022-11-09)
      [Abstract] Background: We aimed to describe recent trends in the use and outcomes of temporary mechanical circulatory support (MCS) as a bridge to heart transplantation (HTx) in Spain. Methods: Retrospective case-by-case ...