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Analysis of the Chondrogenic Potential and Secretome of Mesenchymal Stem Cells Derived from Human Umbilical Cord Stroma
(Mary Ann Liebert, 2011-06-28)
[Abstract] Mesenchymal stem cells (MSCs) from umbilical cord stroma were isolated by plastic adherence and characterized by flow cytometry, looking for cells positive for OCT3/4 and SSEA-4 as well as the classic MSC markers ...
Differentiation of Murine Embryonic Stem Cells to Thyrocytes Requires Insulin and Insulin-like Growth Factor-1
(Elsevier, 2009-02-14)
[Abstract] The mechanisms controlling thyrocyte development during embryonic stem (ES) cell differentiation have only been partially elucidated, although previous studies have suggested the participation of thyroid stimulating ...
Chondrogenic Potential of Subpopulations of Cells Expressing Mesenchymal Stem Cell Markers Derived from Human Synovial Membranes
(Wiley, 2010-07-21)
[Abstract] In this study we analyzed the chondrogenic potential of subpopulations of mesenchymal stem cells (MSCs) derived from human synovial membranes enriched for CD73, CD106, and CD271 markers. Subpopulations of human ...
Differentiation of Synovial CD-105+ Human Mesenchymal Stem Cells into Chondrocyte-like Cells through Spheroid Formation
(Wiley, 2009-06-18)
[Abstract] Mesenchymal stem cells (MSCs) have the capacity to differentiate into several cell lineages, some of which can generate bone, cartilage, or adipose tissue. The presence of MSCs in the synovial membrane was ...
Umbilical Cord as a Mesenchymal Stem Cell Source for Treating Joint Pathologies
(Baishideng, 2011-06-18)
[Abstract] Articular cartilage disorders and injuries often result in life-long chronic pain and compromised quality of life. Regrettably, the regeneration of articular cartilage is a continuing challenge for biomedical ...
High-Throughput Screen Detects Calcium Signaling Dysfunction in Hutchinson-Gilford Progeria Syndrome
(MDPI, 2021-07-07)
[Abstract] Hutchinson–Gilford progeria syndrome (HGPS) is a deadly childhood disorder, which is considered a very rare disease. It is caused by an autosomal dominant mutation on the LMNA gene, and it is characterized by ...
Influence of mesenchymal stem cell-derived extracellular vesicles in vitro and their tole in ageing
(Springer Nature, 2020-01-03)
[Abstract]
Introduction: This study assessed whether mesenchymal stem cell (MSC)-derived extracellular vesicles influenced
ageing and pluripotency markers in cell cultures where they are added.
Methods: MSC-derived ...
Mesenchymal stromal cells for articular cartilage repair: preclinical studies
(AO Research Institute Davos (ARI), 2020-08-26)
[Abstract]
Rheumatic diseases such as osteoarthritis (OA) are a major social and economic burden because of the
population aging and the lack of curative solutions. An effective cell therapy may be the best treatment ...
Next-generation sequencing and quantitative proteomics of Hutchinson-Gilford progeria syndrome-derived cells point to a role of nucleotide metabolism in premature aging
(PLOS, 2018-10-31)
[Abstract] Hutchinson-Gilford progeria syndrome (HGPS) is a very rare fatal disease characterized for accelerated aging. Although the causal agent, a point mutation in LMNA gene, was identified more than a decade ago, the ...
The addition of albumin improves Schwann cells viability in nerve cryopreservation
(Springer, 2018-04-26)
[Abstract] The purpose of the current study was to establish a valid protocol for nerve cryopreservation, and to evaluate if the addition of albumin supposed any advantage in the procedure. We compared a traditional ...