• A Meta-Analysis of Genome-Wide Association Studies Identifies Novel Variants Associated with Osteoarthritis of the Hip 

      Evangelou, Evangelos; Kerkhof, Hanneke J.; Styrkarsdottir, Unnur; Ntzani, Evangelia E.; Bos, Steffan D.; Esko, Tonu; Evans, Daniel S.; Metrustry, Sarah; Panoutsopoulou, Kalliope; Ramos, Yolande F. M.; Thorleifsson, Gudmar; Tsilidis, Konstantinos K.; Arden, Nigel; Aslam, Nadim; Bellamy, Nicholas; Birrell, Fraser; Blanco García, Francisco J; Carr, Andrew; Chapman, Kay; Day-Williams, Aaaron G.; Deloukas, Panos; Doherty, Michael; Engström, Gunnar; Helgadottir, Hafdis T.; Hofman, Albert; Ingvarsson, Thorvaldur; Jonsson, Helgi; Keis, Aime; Keurentjes, J. Christiaan; Kloppenburg, Margreet; Lind, Penelope A.; McCaskie, Andrew; Martin, Nicholas G.; Milani, Lili; Montgomery, Grant W.; Nelissen, Rob G.H.H.; Nevitt, Michael C.; Nilsson, Peter M.; Ollier, William E.R.; Parimi, Neeta; Rai, Ashok; Ralston, Stuart H.; Reed, Mike R.; Riancho, José A.; Rivadeneira, Fernando; Rodríguez-Fontenla, Cristina; Southam, Lorraine; Thorsteindottir, Unnur; Tsezou, Aspasia; Wallis, Gillian A.; Wilkinson, J. Mark; González, Antonio; Lane, Nancy E.; Lohmander, L. Stefan; Loughlin, John; Metspalu, Andres; Uitterlinden, André G.; Jonsdottir, Ingileif; Stefansson, Kari; Slagboom, P. Eline; Zeggini, Eleftheria; Meulebelt, Ingrid; Ionnidis, John P.A.; Spector, Tim D.; van Meurs, Joyce B.J.; Valdes, Ana M. (BMJ, 2013-08-29)
      [Abstract] OBJECTIVES: Osteoarthritis (OA) is the most common form of arthritis with a clear genetic component. To identify novel loci associated with hip OA we performed a meta-analysis of genome-wide association studies ...
    • Baseline clinical characteristics of predicted structural and pain progressors in the IMI-APPROACH knee OA cohort 

      van Helvoort, Eefje M.; Ladel, Christoph H.; Mastbergen, Simon; Kloppenburg, Margreet; Blanco García, Francisco J; Haugen, Ida K.; Berenbaum, Francis; Bacardit, Jaume; Widera, Pawel; Welsing, Paco M.J.; Lafeber, Floris (BMJ, 2021-08-23)
      [Abstract] Objectives: To describe the relations between baseline clinical characteristics of the Applied Public-Private Research enabling OsteoArthritis Clinical Headway (IMI-APPROACH) participants and their predicted ...
    • Cardiovascular disease in immune-mediated inflammatory diseases: a cross-sectional analysis of 6 cohorts 

      Fernández-Gutiérrez, Benjamín; Perrotti, Pedro P.; Gisbert, Javier P.; Doménech, Eugeni; Fernández-Nebro, Antonio; Cañete, Juan D.; Ferrándiz, Carlos; Tornero, Jesús; García-Sánchez, Valle; Panés, Julián; Fonseca, Eduardo; Blanco García, Francisco J; Rodríguez-Moreno, Jesús; Carreira, Patricia; Juliá, Antonio; Marsal, Sara; Rodríguez-Rodríguez, Luis (Wolters Kluwer, 2017-06)
      [Abstract] To analyze in several immune-mediated inflammatory diseases (IMIDs) the influence of demographic and clinical-related variables on the prevalence of cardiovascular disease (CVD), and compare their standardized ...
    • International Consortium for Health Outcomes Measurement (ICHOM): standardized patient-centered outcomes measurement set for heart failure patients 

      Burns, Daniel J.P.; Arora, Jason; Okunade, Oluwakemi; Beltrame, John F.; Bernardez-Pereira, Sabrina; Crespo-Leiro, María Generosa; Filippatos, Gerasimos; Hardman, Suzanna; Hoes, Arno W.; Hutchinson, Steven; Jessup, Mariell; Kinsella, Tina; Knapton, Michael; Lam, Carolyn S.P.; Masoudi, Frederick A.; McIntyre, Hugh; Mindham, Richard; Morgan, Louise; Otterspoor, Luuk; Parker, Victoria; Peerson, Hans E.; Pinnock, Claude; Reid, Christopher M.; Riley, Jillian; Stevenson, Lynne W.; McDonagh, Theresa A. (American College of Cardiology Foundation, 2020-03)
      [Abstract] Whereas multiple national, international, and trial registries for heart failure have been created, international standards for clinical assessment and outcome measurement do not currently exist. The working ...
    • Mitochondrial DNA haplogroups influence the risk of incident knee osteoarthritis in OAI and CHECK cohorts: a meta-analysis and functional study 

      Fernández-Moreno, Mercedes; Soto-Hermida, Ángel; Vázquez-Mosquera, María E.; Cortés-Pereira, Estefanía; Relaño, Sara; Hermida Gómez, Tamara; Pértega-Díaz, Sonia; Oreiro, Natividad; Fernández-López, Carlos; Garesse, Rafael; Blanco García, Francisco J; Rego-Pérez, Ignacio (BMJ, 2016-12-05)
      [Abstract] Objective To evaluate the influence of the mitochondrial DNA (mtDNA) haplogroups in the risk of incident knee osteoarthritis (OA) and to explain the functional consequences of this association to identify potential ...
    • Osteoarthritis endotype discovery via clustering of biochemical marker data 

      Angelini, Federico; Widera, Pawel; Mobasheri, Ali; Blair, Joseph; Struglics, André; Uebelhoer, Melanie; Hentorin, Yves; Marijnissen, Anne CA; Kloppenburg, Margreet; Blanco García, Francisco J; Haugen, Ida K.; Berenbaum, Francis; Ladel, Christoph; Larkin, Jonathan; Bay-Jensen, Anne C.; Bacardit, Jaume (BMJ, 2022-04-08)
      [Abstract] Objectives: Osteoarthritis (OA) patient stratification is an important challenge to design tailored treatments and drive drug development. Biochemical markers reflecting joint tissue turnover were measured in ...
    • Prevalence of electrocardiographic patterns associated with sudden cardiac death in the spanish population aged 40 years or older: results of the OFRECE study 

      Awamleh García, Paula; Alonso, Joaquin J; Graupner Abad, Catherine; Jiménez Hernández, Rosa María; Curcio Ruigómez, Alejandro; Talavera Calle, Pedro; Cristóbal Varela, Carmen; Serrano Antolín, José; Muñiz, Javier; Gómez Doblas, Juan José; Roig, Eulàlia (Elsevier para Sociedad Española de Cardiología, 2017-01-23)
      [Abstract] Introduction and objectives. Some electrocardiographic patterns are associated with an increased risk of sudden cardiac death due to ventricular arrhythmias. There is no information on the prevalence of these ...
    • Prevalence of hospital PCR-confirmed COVID-19 cases in patients with chronic inflammatory and autoimmune rheumatic diseases 

      Pablos, José L.; Abasolo, Lydia; Álvaro-Gracia, José M.; Blanco García, Francisco J; Blanco, Ricardo; Castrejón, Isabel; Fernández-Fernández, David; Fernández-Gutiérrez, Benjamín; Galindo-Izquierdo, María; González-Gay, Miguel Á.; Manrique-Arija, Sara; Mena Vázquez, Natalia; Mera Varela, Antonio; Retuerto, Miriam; Seijas-López, Álvaro (BMJ, 2020-06-12)
      [Abstract] Background: The susceptibility of patients with rheumatic diseases and the risks or benefits of immunosuppressive therapies for COVID-19 are unknown. Methods: We performed a retrospective study with patients ...
    • Prevalence of Stable Angina in Spain: results of the OFRECE Study 

      Alonso, Joaquin J; Muñiz, Javier; Gómez Doblas, Juan José; Rodríguez-Roca, Gustavo; Lobos, José María; Permanyer-Miralda, Gaietá; Anguita, Manuel; Chorro, Francisco Javier; Roig, Eulàlia (Elsevier, 2015-02-17)
      [Abstract] Introduction and objectives. The objective of the OFRECE study was to estimate the prevalence of stable angina in Spain. This prevalence is currently unknown, due to a lack of recent studies and to changes in ...
    • Prevalence of Systemic Lupus Erythematosus in Spain: Higher than Previously Reported in Other Countries? 

      Cortés Verdú, Raúl; Pego-Reigosa, J.; Seoane-Mato, Daniel; Morcillo Valle, Mercedes; Palma Sánchez, Deseada; Moreno Martínez, María J.; Mayor González, Marta; Atxotegi Sáez de Buruaga, Joana; Urionagüena Onaindia, Irati; Blanco Cáceres, Boris A.; Silva-Fernández, Lucía; Sivera, Francisca; Blanco García, Francisco J; Sánchez-Piedra, Carlos; Díaz-González, Federico; Bustabad, Sagrario (Oxford, 2020-01-30)
      [Abstract] Objectives: Prevalence of SLE varies among studies, being influenced by study design, geographical area and ethnicity. Data about the prevalence of SLE in Spain are scarce. In the EPISER2016 study, promoted by ...
    • Prevalence of Systemic Lupus Erythematosus in Spain: Higher than Previously Reported in other Countries? 

      Cortés Verdú, Raúl; Pego-Reigosa, J.; Seoane-Mato, Daniel; Morcillo Valle, Mercedes; Palma Sánchez, Deseada; Moreno Martínez, María J.; Mayor González, Marta; Atxotegi Sáez de Buruaga, Joana; Urionagüena Onaindia, Irati; Blanco Cáceres, Boris A.; Silva-Fernández, Lucía; Sivera, Francisca; Blanco García, Francisco J; Sánchez-Piedra, Carlos; Díaz-González, Federico; Bustabad, Sagrario (Oxford, 2020-01-30)
      [Abstract] Objectives: Prevalence of SLE varies among studies, being influenced by study design, geographical area and ethnicity. Data about the prevalence of SLE in Spain are scarce. In the EPISER2016 study, promoted by ...
    • Prevalencia de patrones electrocardiográficos asociados a muerte súbita en la población española de 40 años o más: resultados del estudio OFRECE 

      Awamleh García, Paula; Alonso, Joaquin J; Graupner Abad, Catherine; Jiménez Hernández, Rosa María; Curcio Ruigómez, Alejandro; Talavera Calle, Pedro; Cristóbal Varela, Carmen; Serrano Antolín, José; Muñiz, Javier; Gómez Doblas, Juan José; Roig, Eulalia (Elsevier, 2017-01-23)
      [Resumen] Introducción y objetivos: Hay patrones electrocardiográficos asociados a mayor riesgo de muerte súbita por arritmias ventriculares. En España no existe información acerca de su prevalencia en la población. El ...
    • Preventing heart failure: a position paper of the Heart Failure Association in collaboration with the European Association of Preventive Cardiology 

      Piepoli, Massimo Francesco; Adamo, Marianna; Barison, Andrea; Bestetti, Reinaldo B.; Biegus, Jan; Böhm, Michael; Butler, Javed; Carapetis, Jonathan; Ceconi, Claudio; Chioncel, Ovidiu; Coats, Andrew; Crespo-Leiro, María Generosa; de Simone, Giovanni; Drexel, Heinz; Emdin, Michele; Farmakis, Dimitros; Halle, Martin; Heymans, Stephane; Jaarsma, Tiny; Jankowska, Ewa; Lainscak, Mitja; Lam, Carolyn S.P.; Løchen, Maja-Lisa; Lopatin, Yuri; Maggioni, Aldo; Matrone, Benedetta; Metra, Marco; Noonan, Katharine; Pina, Ileana; Prescott, Eva; Rosano, Giuseppe; Seferovic, Petar M.; Sliwa, Karen; Stewart, Simon; Uijl, Alicia; Vaartjes, Ilonca; Vermeulen, Roel; Verschuren, W.M.; Volterrani, Maurizio; Von Haehling, Stephan; Hoes, Arno (Oxford Academic, 2022-01-27)
      [Abstract] The heart failure epidemic is growing and its prevention, in order to reduce associated hospital readmission rates and its clinical and economic burden, is a key issue in modern cardiovascular medicine. The ...
    • Trends in the presentation and management of traumatic spinal cord lesions above T6: 20-Year experience in a tertiary-level hospital in Spain 

      Esmorís, Inés; Galeiras, Rita; Seoane-Quiroga, L.; Ferreiro-Velasco, María Elena; Pértega-Díaz, Sonia (Taylor & Francis, 2021-01-14)
      [Abstract] Objective: To analyze the changes in demographic and lesion characteristics of persons with acute traumatic spinal cord injury (ATSCI) above T6 over a period of 20 years, and to evaluate their impact on ICU ...