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Evaluation of COX-2, EGFR, and p53 as biomarkers of non-dysplastic oral leukoplakias
dc.contributor.author | Díaz-Prado, Silvia | |
dc.contributor.author | López Cedrún, José Luis | |
dc.contributor.author | Luaces Rey, Ramón | |
dc.contributor.author | Medina Villaamil, Vanessa | |
dc.contributor.author | Álvarez García, Augusto | |
dc.contributor.author | Valladares-Ayerbes, Manuel | |
dc.contributor.author | Antón-Aparicio, Luis M. | |
dc.date.accessioned | 2015-06-19T08:31:32Z | |
dc.date.available | 2015-06-19T08:31:32Z | |
dc.date.issued | 2010-07-01 | |
dc.identifier.citation | Díaz Prado S, López Cedrún JL, Luaces Rey R, Medina Villamil V, Álvarez García A, Valladares Ayerbes M, et al. Evaluation of COX-2, EGFR, and p53 as biomarkers of non-dysplastic oral leukoplakias. Exp Mol Pathol. 2010;89(2):197-203. | es_ES |
dc.identifier.uri | http://hdl.handle.net/2183/14708 | |
dc.description.abstract | [Abstract] Objective. Identify candidate SEBs (surrogate endpoint biomarkers) for premalignant trends in head and neck mucosa. Study design. Study, by qPCR (quantitative real-time polymerase chain reaction), the expression of COX-2, EGFR and p53 in 24 biopsies of non-dysplastic oral leukoplakia and contra-lateral normal-appearing mucosa. Results. COX-2 was up-regulated in leukoplakia (79.2%); whereas EGFR and p53 were up-regulated (p > 0.05) in oral contra-lateral normal-appearing mucosa (60% and 46% respectively). Also, p53 expression was correlated with tobacco smoke habits and Spearman's rank correlation coefficient showed a positive linear correlation between p53 and EGFR mRNA expression levels. Conclusions. COX-2 would serve as SEB of oral leukoplakia. The results suggest that p53 appears to be one of the molecular targets of tobacco-related carcinogens in leukoplakia and that the co-expression of p53 and EGFR may play a role in this kind of oral pre-cancerous lesion. More detailed studies of EGFR and p53 should be continued in the future. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Elsevier | es_ES |
dc.relation.uri | http://dx.doi.org/10.1016/j.yexmp.2010.06.004 | es_ES |
dc.rights | Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International Licence (CC-BY-NC-ND 4.0) | |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.subject | EGFR | es_ES |
dc.subject | COX-2 | es_ES |
dc.subject | p53 | es_ES |
dc.subject | Oral leukoplakia | es_ES |
dc.subject | Quantitative real-time PCR | es_ES |
dc.subject | Molecular marker | es_ES |
dc.title | Evaluation of COX-2, EGFR, and p53 as biomarkers of non-dysplastic oral leukoplakias | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.access | info:eu-repo/semantics/openAccess | es_ES |
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