• Effect of miR-21 in mesenchymal stem cells-derived extracellular vesicles behavior 

      Morente-López, Miriam; Mato-Basalo, Rocío; Lucio-Gallego, Sergio; Gil, Concha; Carrera, Mónica; Fafián Labora, Juan Antonio; Arufe, M.C. (BioMed Central, 2023-12-21)
      [Abstract] Background: A challenging new branch of research related to aging-associated diseases is the identification of miRNAs capable of modulating the senescence-associated secretory phenotype (SASP) which characterizes ...
    • NF-κB/IKK Activation by Small Extracellular Vesicles Within the SASP 

      Fafián Labora, Juan Antonio; O'Loghlen, Ana (Wiley, 2021-06-29)
      [Abstract] Cellular senescence plays an important role in different biological and pathological conditions. Senescent cells communicate with their microenvironment through a plethora of soluble factors, metalloproteases ...
    • Therapy free of cells vs human mesenchymal stem cells from umbilical cord stroma to treat the inflammation in OA 

      Morente-López, Miriam; Mato-Basalo, Rocío; Lucio-Gallego, Sergio; Silva-Fernández, Lucía; González-Rodríguez, Alba; De-Toro, Javier; Fafián Labora, Juan Antonio; Arufe, M.C. (Springer, 2022-10-20)
      [Abstract] Osteoarthritis (OA) is closely linked to the increase in the number of senescent cells in joint tissues, and the senescence-associated secretory phenotype (SASP) is implicated in cartilage degradation. In the ...