Listar GI-TCMR - Artigos por autor "Cucchiarini, Magali"
Mostrando ítems 1-10 de 10
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Biomaterial-Assisted Gene Therapy for Translational Approaches to Treat Musculoskeletal Disorders
Venkatesan, Jagadeesh Kumar; Rey-Rico, Ana; Meng, Weikun; Cai, Xiaoyu; Pons, Françoise; Lebeau, Luc; Migonney, Véronique; Madry, Henning; Cucchiarini, Magali (Elsevier, 2020-12-28)[Abstract] Biomaterial-assisted gene therapy is a promising strategy for the treatment of various musculoskeletal disorders such as those concerning the articular cartilage, bones, tendons and ligaments, and meniscus as ... -
Controlled Release of rAAV Vectors from APMA-Functionalized Contact Lenses for Corneal Gene Therapy
Álvarez-Rivera, Fernando; Rey-Rico, Ana; Venkatesan, Jagadeesh K.; Díaz-Gómez, Luis; Cucchiarini, Magali; Concheiro, Ángel; Álvarez-Lorenzo, Carmen (MDPI, 2020-04-09)[Abstract] As an alternative to eye drops and ocular injections for gene therapy, the aim of this work was to design for the first time hydrogel contact lenses that can act as platforms for the controlled delivery of ... -
Current trends in viral gene therapy for human orthopaedic regenerative medicine
Venkatesan, Jagadeesh Kumar; Rey-Rico, Ana; Cucchiarini, Magali (Springer, 2019-02-21)[Abstract] Background: Viral vector-based therapeutic gene therapy is a potent strategy to enhance the intrinsic reparative abilities of human orthopaedic tissues. However, clinical application of viral gene transfer remains ... -
Effective remodelling of human osteoarthritic cartilage by sox9 gene transfer and overexpression upon delivery of rAAV vectors in polymeric micelles
Rey-Rico, Ana; Venkatesan, Jagadesh K.; Schmitt, Gertrud; Speicher-Mentges, Susanne; Madry, Henning; Cucchiarini, Magali (American Chemical Society, 2018-05-15)[Abstract] Recombinant adeno-associated virus (rAAV) vectors are well suited carriers to provide durable treatments for human osteoarthritis (OA). Controlled release of rAAV from polymeric micelles was already shown to ... -
PEO-PPO-PEO tri-block copolymers for gene delivery applications in human regenerative medicine: an overview
Rey-Rico, Ana; Cucchiarini, Magali (MDPI, 2018-03-08)[Abstract] Lineal (poloxamers or Pluronic®) or X-shaped (poloxamines or Tetronic®) amphiphilic tri-block copolymers of poly(ethylene oxide) and poly(propylene oxide) (PEO-PPO-PEO) have been broadly explored for controlled ... -
rAAV-Mediated Overexpression of SOX9 and TGF-β via Carbon Dot-Guided Vector Delivery Enhances the Biological Activities in Human Bone Marrow-Derived Mesenchymal Stromal Cells
Meng, Weikun; Rey-Rico, Ana; Claudel, Mickaël; Schmitt, Gertrud; Speicher-Mentges, Susanne; Pons, Françoise; Lebeau, Luc; Venkatesan, Jagadeesh K.; Cucchiarini, Magali (MDPI, 2020-04-28)[Abstract] Scaffold-assisted gene therapy is a highly promising tool to treat articular cartilage lesions upon direct delivery of chondrogenic candidate sequences. The goal of this study was to examine the feasibility ... -
Remodeling of human osteochondral defects via rAAV-mediated co-overexpression of TGF-β and IGF-I from implanted human bone marrow-derived mesenchymal stromal cells
Morscheid, Stephanie; Venkatesan, Jagadeesh Kumar; Rey-Rico, Ana; Schmitt, Gertrud; Cucchiarini, Magali (MDPI, 2019-08-28)[Abstract] The application of chondrogenic gene sequences to human bone marrow-derived mesenchymal stromal cells (hMSCs) is an attractive strategy to activate the reparative activities of these cells as a means to enhance ... -
Scaffold-Mediated Gene Delivery for Osteochondral Repair
Madry, Henning; Venkatesan, Jagadeesh Kumar; Carballo-Pedrares, Natalia; Rey-Rico, Ana; Cucchiarini, Magali (MDPI, 2020-09-29)[Abstract] Osteochondral defects involve both the articular cartilage and the underlying subchondral bone. If left untreated, they may lead to osteoarthritis. Advanced biomaterial-guided delivery of gene vectors has ... -
Therapeutic Delivery of rAAV sox9 via Polymeric Micelles Counteracts the Effects of Osteoarthritis-Associated Inflammatory Cytokines in Human Articular Chondrocytes
Urich, Jonas; Cucchiarini, Magali; Rey-Rico, Ana (MDPI, 2020-06-25)[Abstract] Osteoarthritis (OA) is a prevalent joint disease linked to the irreversible degradation of key extracellular cartilage matrix (ECM) components (proteoglycans, type-II collagen) by proteolytic enzymes due to an ... -
Therapeutic effects of rAAV-mediated concomittant gene transfer and overexpression of TGF-β and IGF-I on the chondrogenesis of human bone-marrow-derived mesenchymal stem cells
Morscheid, Stephanie; Rey-Rico, Ana; Schmitt, Gertrud; Madry, Henning; Cucchiarini, Magali; Venkatesan, Jagadeesh Kumar (MDPI, 2019-05-27)[Abstract] Application of chondroreparative gene vectors in cartilage defects is a powerful approach to directly stimulate the regenerative activities of bone-marrow-derived mesenchymal stem cells (MSCs) that repopulate ...