Now showing items 1-20 of 47

    • A novel procedure for protein extraction from formalin-fixed paraffin-embedded tissues 

      Rodríguez-Rigueiro, Teresa; Valladares-Ayerbes, Manuel; Haz, Mar; Blanco, Moisés; Aparicio Gallego, Guadalupe; Fernández-Puente, Patricia; Blanco García, Francisco J; Lorenzo-Patiño, María J.; Antón-Aparicio, Luis M.; Figueroa, Angélica (Wiley, 2011-05-18)
      [Abstract] Most of the archived pathological specimens in hospitals are kept as formalin-fixed paraffin-embedded tissues (FFPE) for long-term preservation. Up to now, these samples are only used for immunohistochemistry ...
    • A primary signet ring cell carcinoma of the prostate with bone metastasis with impressive response to FOLFOX and Cetuximab 

      Roldán, Ana Milena; Fernández-Núñez, Natalia; Grande Pulido, Enrique; Álvarez-García, Augusto; Antón-Aparicio, Luis M. (Elsevier, 2012-03-10)
    • Bioinformatics approach to mRNA markers discovery for detection of circulating tumor cells in patients with gastrointestinal cancer 

      Valladares-Ayerbes, Manuel; Díaz Prado, Silvia; Reboredo, Margarita; Medina Villaamil, Vanessa; Iglesias-Díaz, Pilar; Lorenzo-Patiño, María J.; García Campelo, Rosario; Haz, Mar; Santamarina, Isabel; Antón-Aparicio, Luis M. (Elsevier, 2008)
      [Abstract] Background: Detection of tumor cells in the blood, or minimal deposits in distant organs as bone marrow, could be important to identify cancer patients at high risk of relapse or disease progression. Quantitative ...
    • Bioinformatics approach to mRNA markers discovery for detection of circulating tumor cells in patients with gastrointestinal cancer 

      Valladares-Ayerbes, Manuel; Díaz Prado, Silvia; Reboredo, Margarita; Medina Villaamil, Vanessa; Iglesias-Díaz, Pilar; Lorenzo-Patiño, María J.; Campelo, Rosario G.; Haz, Mar; Santamarina, Isabel; Antón-Aparicio, Luis M. (Elsevier, 2008-09-17)
      [Abstract] Background: Detection of tumor cells in the blood, or minimal deposits in distant organs as bone marrow, could be important to identify cancer patients at high risk of relapse or disease progression. Quantitative ...
    • Biological influence of Hakai in cancer: a 10-year review 

      Antón-Aparicio, Luis M.; Valladares-Ayerbes, Manuel; Blanco, Moisés; Alonso, Guillermo; Figueroa, Angélica (Springer, 2012-02-19)
      [Abstract] In order to metastasize, cancer cells must first detach from the primary tumor, migrate, invade through tissues, and attach to a second site. Hakai was discovered as an E3 ubiquitin-ligase that mediates the ...
    • Cabazitaxel for metastatic castration-resistant prostate cancer: safety data from the Spanish expanded access program 

      Castellano, Daniel; Antón-Aparicio, Luis M.; Esteban, Emilio; Sánchez-Hernández, Alfredo; Germá, José Ramón; Batista, Norberto; Maroto, Pablo; Pérez-Valderrama, Begoña; Luque, Raquel; Méndez-Vidal, María José (Taylor & Francis, 2014-07-07)
      [Abstract] BACKGROUND: Based on the TROPIC study results, cabazitaxel was approved for the management of metastatic castration-resistant prostate cancer (mCRPC) progressing on or after docetaxel. METHODS: This multi-centre ...
    • La ciclooxigenasa-2 (COX-2) y el factor de crecimiento epidérmico (EFG) en lesiones epiteliales orales premalignas 

      Díaz Prado, Silvia; Antón-Aparicio, Luis M.; Gallego Guadalupe, A.; López-Cedrún Cembranos, José Luis; Ferreras Granado, José (Sociedad Española de Cirugía Oral y Maxilofacial (SECOM), 2009)
      [Resumen] Las lesiones premalignas orales incluyen eritroplasias (manchas rojas) y leucoplasias (manchas blancas), las cuales se desarrollan a lo largo de superficies epiteliales. Estas lesiones son considerados marcadores ...
    • Circulating levels of GDF15, MMP7 and miR-200c as a poor prognostic signature in gastric cancer 

      Blanco, Moisés; Tarrío, Nuria; Reboredo, Margarita; Haz, Mar; García, Jorge; Quindós-Varela, María; Figueroa, Angélica; Antón-Aparicio, Luis M.; Calvo, Lourdes; Valladares-Ayerbes, Manuel (Future Science, 2014-06-20)
      [Abstract] Aim: To analyze GDF15 and MMP7 serum levels as diagnostic biomarkers in gastric cancer (GC) patients. The prognostic value of GDF15 and MMP7 serum levels in combination with miR-200c blood expression was also ...
    • Circulating microRNAs: molecular microsensors in gastrointestinal cancer 

      Blanco, Moisés; Calvo, Lourdes; Figueroa, Angélica; Haz, Mar; Antón-Aparicio, Luis M.; Valladares-Ayerbes, Manuel (MPDI, 2012-07-09)
      [Abstract] MicroRNAs (miRNAs) are small molecules of single strand non-coding RNAs, which are able to regulate gene expression. miRNAs have been involved in multiple cellular processes, such as proliferation, apoptosis and ...
    • Circulating miR-200c and miR-141 and outcomes in patients with breast cancer 

      Antolín, Silvia; Calvo, Lourdes; Blanco, Moisés; Paz Santiago, María; Lorenzo-Patiño, María J.; Haz, Mar; Santamarina, Isabel; Figueroa, Angélica; Antón-Aparicio, Luis M.; Valladares-Ayerbes, Manuel (BioMed Central, 2015)
      [Abstract] Background. The deregulation of microRNAs in both tumours and blood has led to the search for microRNAs to indicate the presence of cancer and predict prognosis. We hypothesize the deregulation of miR-200c/miR-141 ...
    • Circulating miR-200c as a diagnostic and prognostic biomarker for gastric cancer 

      Valladares-Ayerbes, Manuel; Reboredo, Margarita; Medina Villaamil, Vanessa; Iglesias-Díaz, Pilar; Lorenzo-Patiño, María J.; Haz, Mar; Santamarina, Isabel; Blanco, Moisés; Fernández-Tajes, Juan; Quindós-Varela, María; Carral, Alberto; Figueroa, Angélica; Antón-Aparicio, Luis M.; Calvo, Lourdes (BioMed Central, 2012-09-06)
      [Abstract] Background. MicroRNAs are aberrantly expressed and correlate with tumourigenesis and the progression of solid tumours. The miR-200 family determines the epithelial phenotype of cancer cells and regulates ...
    • Clinical implications of epithelial cell plasticity in cancer progression 

      Antón-Aparicio, Luis M.; Blanco, Moisés; Castosa, Raquel; Concha, Ángel; Valladares-Ayerbes, Manuel; Calvo, Lourdes; Figueroa, Angélica (Elsevier, 2015)
      [Abstract] In the last few years, the role of epithelial cell plasticity in cancer biology research has gained increasing attention. This concept refers to the ability of the epithelial cells to dynamically switch between ...
    • Comprehensive lung injury pathology induced by mTOR inhibitors 

      Aparicio Gallego, Guadalupe; Medina, Vanessa; Fernández, Ovidio; Jiménez, Paula; Lema, Martina; Figueroa, Angélica; Antón-Aparicio, Luis M. (Springer para Federation of Spanish Oncology Sociesties (FESEO), 2009-08-29)
      [Abstract] Interstitial lung disease is a rare side effect of temsirolimus treatment in renal cancer patients. Pulmonary fibrosis is characterised by the accumulation of extracellular matrix collagen, fibroblast proliferation ...
    • Crossing paths in Human Renal Cell Carcinoma (hRCC) 

      Aparicio Gallego, Guadalupe; Medina Villaamil, Vanessa; Grande Pulido, Enrique; Santamarina, Isabel; Antón-Aparicio, Luis M. (MDPI, 2012-10-05)
      [Abstract] Historically, cell-signaling pathways have been studied as the compilation of isolated elements into a unique cascade that transmits extracellular stimuli to the tumor cell nucleus. Today, growing evidence ...
    • Cyclooxygenase-2 (COX-2): a molecular target in prostate cancer 

      Aparicio Gallego, Guadalupe; Díaz Prado, Silvia; Jiménez Fonseca, P.; García Campelo, Rosario; Casinello Espinosa, J.; Antón-Aparicio, Luis M. (Springer, 2007-12-15)
      [Abstract] Epidemiological studies provided the first evidence that COX may be involved in the pathogenesis of cancer. In the process of carcinogenesis and in the route of intracellular signalling during carcinogenesis, ...
    • Diagnostic accuracy of small breast epithelial mucin mRNA as a marker for bone marrow micrometastasis in breast cancer: a pilot study 

      Valladares-Ayerbes, Manuel; Iglesias-Díaz, Pilar; Díaz Prado, Silvia; Ayude, Daniel; Medina Villaamil, Vanessa; Haz, Mar; Reboredo, Margarita; Antolín, Silvia; Calvo, Lourdes; Antón-Aparicio, Luis M. (Springer-Verlag, 2009-02-17)
      [Abstract] Background. Detection of isolated tumour cells (ITC) in the blood or minimal deposits in distant organs such as bone marrow (BM) could be important to identify breast cancer patients at high risk of relapse or ...
    • Effect of a microtubule-targeting drug on cell–cell contacts in bladder epithelial tumour cells 

      Antón-Aparicio, Luis M.; Castosa, Raquel; Haz, Mar; Blanco, Moisés; Rodríguez, M.; Valladares-Ayerbes, Manuel; Figueroa, Angélica (Elsevier, 2014)
    • Enzalutamide: a new prostate cancer targeted therapy against the androgen receptor 

      Lázaro Quintela, Martín; León Mateos, Luis; Vázquez Estévez, Sergio; Fernández Calvo, Ovidio; Anido Herranz, Urbano; Afonso Afonso, Francisco Javier; Santomé, Lucía; Antón-Aparicio, Luis M. (Elsevier, 2015-03)
      [Abstract] Enzalutamide (MDV3100), an androgen receptor-signalling inhibitor, represents the most recent compound added to the therapeutic armamentarium for the treatment of metastatic castration-resistant prostate cancer ...
    • Evaluation of COX-2, EGFR, and p53 as biomarkers of non-dysplastic oral leukoplakias 

      Díaz Prado, Silvia; López Cedrún, José Luis; Luaces Rey, Ramón; Medina Villaamil, Vanessa; Álvarez García, Augusto; Valladares-Ayerbes, Manuel; Antón-Aparicio, Luis M. (Elsevier, 2010-07-01)
      [Abstract] Objective. Identify candidate SEBs (surrogate endpoint biomarkers) for premalignant trends in head and neck mucosa. Study design. Study, by qPCR (quantitative real-time polymerase chain reaction), the expression ...
    • Evaluation of Plakophilin-3 mRNA as a biomarker for detection of circulating tumor cells in gastrointestinal cancer patients 

      Valladares-Ayerbes, Manuel; Díaz Prado, Silvia; Reboredo, Margarita; Medina, Vanessa; Lorenzo-Patiño, María J.; Iglesias-Díaz, Pilar; Haz, Mar; Pértega-Díaz, Sonia; Santamarina, Isabel; Blanco, Moisés; Quindós-Varela, María; Figueroa, Angélica; Antón-Aparicio, Luis M. (American Association for Cancer Research, 2010-05-25)
      [Abstract] Background: This study aims to assess Plakophilin-3 (PKP3) as a surrogate biomarker of circulating tumor cells in patients with gastrointestinal cancer. Methods: The primary aim is to estimate the diagnostic ...