Listar por autor "Angelovski, Goran"
Mostrando ítems 1-11 de 11
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Endeavor toward Redox-Responsive Transition Metal Contrast Agents Based on the Cross-Bridge Cyclam Platform
Uzal-Varela, Rocío; Rodríguez-Rodríguez, Aurora; Lalli, Daniela; Valencia, Laura; Maneiro, Marcelino; Botta, Mauro; Iglesias, Emilia; Esteban-Gómez, David; Angelovski, Goran; Platas-Iglesias, Carlos (American Chemical Society, 2024-01-10)[Abstract]: We present the synthesis and characterization of a series of Mn(III), Co(III), and Ni(II) complexes with cross-bridge cyclam derivatives (CB-cyclam = 1,4,8,11-tetraazabicyclo[6.6.2]hexadecane) containing acetamide ... -
Europium(III) Macrocyclic Chelates Appended with Tyrosine-based Chromophores and Di-(2-picolyl)amine-based Receptors: Turn-On Luminescent Chemosensors Selective to Zinc(II) Ions
Wang, Gaoji; Platas-Iglesias, Carlos; Angelovski, Goran (Wiley, 2020-01-22)[Abstract] Zinc ions play an important role in many biological processes in the human body. To selectively detect Zn²⁺, two EuDO3A‐based complexes (DO3A=1,4,7,10‐tetraazacyclododecane‐1,4,7‐tricarboxylic acid) appended ... -
Gd3+-based magnetic resonance imaging contrast agent responsive to Zn2+
Regueiro-Figueroa, Martín; Gündüz, Serhat; Patinec, Véronique; Logothetis, Nikos K.; Esteban-Gómez, David; Tripier, Raphaël; Angelovski, Goran; Platas-Iglesias, Carlos (American Chemical Society, 2015-10-15)[Abstract] We report the heteroditopic ligand H5L, which contains a DO3A unit for Gd3+ complexation connected to an NO2A moiety through a N-propylacetamide linker. The synthesis of the ligand followed a convergent route ... -
In Situ Ternary Adduct Formation of Yttrium Polyaminocarboxylates Leads to Small Molecule Capture and Activation
Tickner, Ben; Platas-Iglesias, Carlos; Duckett, Simon; Angelovski, Goran (Wiley-VCH, 2022-07-19)[Abstract]: In this work the chemistry of yttrium complexes is exploited for small molecule capture and activation. Nuclear magnetic resonance (NMR) and density functional theory (DFT) studies were used to investigate the ... -
In-depth study of a novel class of ditopic gadolinium(III)-based MRI probes sensitive to zwitterionic neurotransmitters
Toljic, Djordje; Platas-Iglesias, Carlos; Angelovski, Goran (Frontiers, 2019-07-24)[Abstract] The efficacy of Gd-based low-molecular weight ditopic MRI probes on binding zwitterionic neurotransmitters (ZNTs) relies on their structural compatibility. ZNTs are challenging biomarkers for monitoring chemical ... -
Inert macrocyclic Eu3+ complex with affirmative paraCEST features
Gambino, Tanja; Valencia, Laura; Pérez-Lourido, Paulo; Esteban-Gómez, David; Zaiss, Moritz; Platas-Iglesias, Carlos; Angelovski, Goran (Royal Society of Chemistry, 2020-06-21)[Abstract]: We report on a macrocyclic platform based on an 18-membered macrocycle that forms kinetically highly inert paramagnetic complexes and possesses an excellent outlook for the development of bioresponsive paraCEST ... -
Investigations into the effects of linker length elongation on the behaviour of calcium-responsive MRI probes
Connah, Liam; Truffault, Vincent; Platas-Iglesias, Carlos; Angelovski, Goran (Royal Society of Chemistry, 2019-07-25)[Abstract] Understanding the relationship between chemical structure and the effectiveness of bioresponsive magnetic resonance imaging (MRI) contrast agents can offer help to identify key components required for the future ... -
Paramagnetic lanthanide chelates for multicontrast MRI
Cakic, Nevenka; Savic, Tanja; Stricker-Shaver, Janice; Truffault, Vincent; Platas-Iglesias, Carlos; Mirkes, Christian; Pohmann, Rolf; Scheffler, Klaus; Angelovski, Goran (Royal Society of Chemistry, 2016-06-02)[Abstract] The preparation of a paramagnetic chelator that serves as a platform for multicontrast MRI, and can be utilized either as a T1-weighted, paraCEST or 19F MRI contrast agent is reported. Its europium(III) complex ... -
Reinforced Ni(ɪɪ)-Cyclam Derivatives as Dual ¹H/¹⁹F MRI Probes
Pujales-Paradela, Rosa; Savic, Tanja; Brandariz, Isabel; Pérez-Lourido, Paulo; Angelovski, Goran; Esteban-Gómez, David; Platas-Iglesias, Carlos (Royal Society of Chemistry, 2019-03-11)[Abstract] Reinforced cross-bridged Ni²⁺-cyclam complexes were functionalised with pendant arms containing both amide protons and CF₃ groups that lead to a dual ¹H/¹⁹F response. The resulting complexes possess very high ... -
Spectrally undiscerned isomers might lead to erroneous determination of water exchange rates of paraCEST Eu(III) agents
Cakic, Nevenka; Tickner, Ben; Zaiss, Moritz; Esteban-Gómez, David; Platas-Iglesias, Carlos; Angelovski, Goran (American Chemical Society, 2017-07-17)[Abstract] We report a detailed study of the solution structure and water exchange rate of a Eu(III) complex with the cyclen-based ligand L1, containing (S)-2-(2-acetamido)-3-(4 (trifluoromethyl)phenyl)propanoate pendant ... -
Synthesis and characterisation of bismacrocyclic DO3A-amide derivatives – an approach towards metal-responsive PARACEST agents
Cakic, Nevenka; Verbić, Tatjana Ž.; Jelić, Ratomir M.; Platas-Iglesias, Carlos; Angelovski, Goran (Royal Society of Chemistry, 2016-02-26)[Abstract] Three new bismacrocyclic Ln3+ chelates consisting of triamide derivatives of cyclen with glycine, methyl and tert-butyl substituents (L1–3, respectively) linked to an acyclic EGTA-derived calcium chelator were ...
