Listar por autor "Angelovski, Goran"
Mostrando ítems 1-9 de 9
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Europium(III) Macrocyclic Chelates Appended with Tyrosine-based Chromophores and Di-(2-picolyl)amine-based Receptors: Turn-On Luminescent Chemosensors Selective to Zinc(II) Ions
Wang, Gaoji; Platas-Iglesias, Carlos; Angelovski, Goran (Wiley, 2020-01-22)[Abstract] Zinc ions play an important role in many biological processes in the human body. To selectively detect Zn²⁺, two EuDO3A‐based complexes (DO3A=1,4,7,10‐tetraazacyclododecane‐1,4,7‐tricarboxylic acid) appended ... -
Gd3+-based magnetic resonance imaging contrast agent responsive to Zn2+
Regueiro-Figueroa, Martín; Gündüz, Serhat; Patinec, Véronique; Logothetis, Nikos K.; Esteban-Gómez, David; Tripier, Raphaël; Angelovski, Goran; Platas-Iglesias, Carlos (American Chemical Society, 2015-10-15)[Abstract] We report the heteroditopic ligand H5L, which contains a DO3A unit for Gd3+ complexation connected to an NO2A moiety through a N-propylacetamide linker. The synthesis of the ligand followed a convergent route ... -
In-depth study of a novel class of ditopic gadolinium(III)-based MRI probes sensitive to zwitterionic neurotransmitters
Toljic, Djordje; Platas-Iglesias, Carlos; Angelovski, Goran (Frontiers, 2019-07-24)[Abstract] The efficacy of Gd-based low-molecular weight ditopic MRI probes on binding zwitterionic neurotransmitters (ZNTs) relies on their structural compatibility. ZNTs are challenging biomarkers for monitoring chemical ... -
Inert macrocyclic Eu3+ complex with affirmative paraCEST features
Gambino, Tanja; Valencia, Laura; Pérez-Lourido, Paulo; Esteban-Gómez, David; Zaiss, Moritz; Platas-Iglesias, Carlos; Angelovski, Goran (Royal Society of Chemistry, 2020-06-21)[Abstract]: We report on a macrocyclic platform based on an 18-membered macrocycle that forms kinetically highly inert paramagnetic complexes and possesses an excellent outlook for the development of bioresponsive paraCEST ... -
Investigations into the effects of linker length elongation on the behaviour of calcium-responsive MRI probes
Connah, Liam; Truffault, Vincent; Platas-Iglesias, Carlos; Angelovski, Goran (Royal Society of Chemistry, 2019-07-25)[Abstract] Understanding the relationship between chemical structure and the effectiveness of bioresponsive magnetic resonance imaging (MRI) contrast agents can offer help to identify key components required for the future ... -
Paramagnetic lanthanide chelates for multicontrast MRI
Cakic, Nevenka; Savic, Tanja; Stricker-Shaver, Janice; Truffault, Vincent; Platas-Iglesias, Carlos; Mirkes, Christian; Pohmann, Rolf; Scheffler, Klaus; Angelovski, Goran (Royal Society of Chemistry, 2016-06-02)[Abstract] The preparation of a paramagnetic chelator that serves as a platform for multicontrast MRI, and can be utilized either as a T1-weighted, paraCEST or 19F MRI contrast agent is reported. Its europium(III) complex ... -
Reinforced Ni(ɪɪ)-Cyclam Derivatives as Dual ¹H/¹⁹F MRI Probes
Pujales-Paradela, Rosa; Savic, Tanja; Brandariz, Isabel; Pérez-Lourido, Paulo; Angelovski, Goran; Esteban-Gómez, David; Platas-Iglesias, Carlos (Royal Society of Chemistry, 2019-03-11)[Abstract] Reinforced cross-bridged Ni²⁺-cyclam complexes were functionalised with pendant arms containing both amide protons and CF₃ groups that lead to a dual ¹H/¹⁹F response. The resulting complexes possess very high ... -
Spectrally undiscerned isomers might lead to erroneous determination of water exchange rates of paraCEST Eu(III) agents
Cakic, Nevenka; Tickner, Ben; Zaiss, Moritz; Esteban-Gómez, David; Platas-Iglesias, Carlos; Angelovski, Goran (American Chemical Society, 2017-07-17)[Abstract] We report a detailed study of the solution structure and water exchange rate of a Eu(III) complex with the cyclen-based ligand L1, containing (S)-2-(2-acetamido)-3-(4 (trifluoromethyl)phenyl)propanoate pendant ... -
Synthesis and characterisation of bismacrocyclic DO3A-amide derivatives – an approach towards metal-responsive PARACEST agents
Cakic, Nevenka; Verbić, Tatjana Ž.; Jelić, Ratomir M.; Platas-Iglesias, Carlos; Angelovski, Goran (Royal Society of Chemistry, 2016-02-26)[Abstract] Three new bismacrocyclic Ln3+ chelates consisting of triamide derivatives of cyclen with glycine, methyl and tert-butyl substituents (L1–3, respectively) linked to an acyclic EGTA-derived calcium chelator were ...