Paramagnetic lanthanide chelates for multicontrast MRI
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TitleParamagnetic lanthanide chelates for multicontrast MRI
Cakic N., Savic T., Stricker-Shaver J., Truffault V., Platas-Iglesias C., Mirkes C., et al. Paramagnetic lanthanide chelates for multicontrast MRI. Chem. Commun. 2016, 59, 9224. https://doi.org/10.1039/C6CC04011J
[Abstract] The preparation of a paramagnetic chelator that serves as a platform for multicontrast MRI, and can be utilized either as a T1-weighted, paraCEST or 19F MRI contrast agent is reported. Its europium(III) complex exhibits an extremely slow water exchange rate which is optimal for the use in CEST MRI. The potential of this platform was demonstrated through a series of MRI studies on tube phantoms and animals.