Reinforced Ni(ɪɪ)-Cyclam Derivatives as Dual ¹H/¹⁹F MRI Probes
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Reinforced Ni(ɪɪ)-Cyclam Derivatives as Dual ¹H/¹⁹F MRI ProbesAutor(es)
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2019-03-11Cita bibliográfica
R. Pujales-Paradela, T. Savić, I. Brandariz, P. Pérez-Lourido, G. Angelovski, D. Esteban-Gómez and C. Platas-Iglesias, Reinforced Ni(II)-cyclam derivatives as dual 1H/19F MRI probes, Chem. Commun., 2019, 55, 4115–4118. DOI: 10.1039/C9CC01204D
Resumo
[Abstract] Reinforced cross-bridged Ni²⁺-cyclam complexes were functionalised with pendant arms containing both amide protons and CF₃ groups that lead to a dual ¹H/¹⁹F response. The resulting complexes possess very high inertness favourable for MRI applications. The paramagnetism of the Ni²⁺ ion shifts the amide resonance 56 ppm away from bulk water favouring the chemical exchange saturation transfer (CEST) effect and shortening the acquisition times in ¹⁹F magnetic resonance imaging (MRI) experiments, thus enhancing the signal-to-noise ratios compared to the fluorinated diamagnetic reference.
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1364-548X