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Reinforced Ni(ɪɪ)-Cyclam Derivatives as Dual ¹H/¹⁹F MRI Probes
dc.contributor.author | Pujales-Paradela, Rosa | |
dc.contributor.author | Savic, Tanja | |
dc.contributor.author | Brandariz, Isabel | |
dc.contributor.author | Pérez-Lourido, Paulo | |
dc.contributor.author | Angelovski, Goran | |
dc.contributor.author | Esteban-Gómez, David | |
dc.contributor.author | Platas-Iglesias, Carlos | |
dc.date.accessioned | 2022-03-18T09:23:10Z | |
dc.date.available | 2022-03-18T09:23:10Z | |
dc.date.issued | 2019-03-11 | |
dc.identifier.citation | R. Pujales-Paradela, T. Savić, I. Brandariz, P. Pérez-Lourido, G. Angelovski, D. Esteban-Gómez and C. Platas-Iglesias, Reinforced Ni(II)-cyclam derivatives as dual 1H/19F MRI probes, Chem. Commun., 2019, 55, 4115–4118. DOI: 10.1039/C9CC01204D | es_ES |
dc.identifier.issn | 1364-548X | |
dc.identifier.uri | http://hdl.handle.net/2183/30055 | |
dc.description.abstract | [Abstract] Reinforced cross-bridged Ni²⁺-cyclam complexes were functionalised with pendant arms containing both amide protons and CF₃ groups that lead to a dual ¹H/¹⁹F response. The resulting complexes possess very high inertness favourable for MRI applications. The paramagnetism of the Ni²⁺ ion shifts the amide resonance 56 ppm away from bulk water favouring the chemical exchange saturation transfer (CEST) effect and shortening the acquisition times in ¹⁹F magnetic resonance imaging (MRI) experiments, thus enhancing the signal-to-noise ratios compared to the fluorinated diamagnetic reference. | es_ES |
dc.description.sponsorship | Authors R. P.-P., D. E.-G. and C. P.-I. thank Ministerio de Economía y Competitividad (CTQ2016-76756-P) and Xunta de Galicia (ED431B 2017/59 and ED431D 2017/01) for generous financial support. R. P.-P. thanks Ministerio de Economía y Competitividad for a PhD FPI grant (BES-2014-068399) and a fellowship for a short term stay in Tuebingen (EEBB-I-17-12213). T. S. thanks the German Academic Exchange Service (DAAD) for the PhD fellowship | es_ES |
dc.description.sponsorship | Xunta de Galicia; ED431B 2017/59 | es_ES |
dc.description.sponsorship | Xunta de Galicia; ED431D 2017/01 | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Royal Society of Chemistry | es_ES |
dc.relation | info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/CTQ2016-76756-P/ES/NUEVA GENERACION DE AGENTES DE CONTRASTE PARA IMAGEN POR RESONANCIA MAGNETICA (IRM) ALTERNATIVOS A LOS DERIVADOS DE GADOLINIO/ | |
dc.relation | info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/BES-2014-068399/ES/ | |
dc.relation | info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/EEBB-I-17-12213/ES/ | |
dc.relation.uri | https://doi.org/10.1039/C9CC01204D | es_ES |
dc.title | Reinforced Ni(ɪɪ)-Cyclam Derivatives as Dual ¹H/¹⁹F MRI Probes | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.access | info:eu-repo/semantics/openAccess | es_ES |
UDC.journalTitle | Chemical Communications | es_ES |
UDC.volume | 55 | es_ES |
UDC.issue | 28 | es_ES |
UDC.startPage | 4115 | es_ES |
UDC.endPage | 4118 | es_ES |
dc.identifier.doi | 10.1039/C9CC01204D |
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