Inert macrocyclic Eu3+ complex with affirmative paraCEST features
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Inert macrocyclic Eu3+ complex with affirmative paraCEST featuresAutor(es)
Data
2020-06-21Cita bibliográfica
Inorg. Chem. Front., 2020,7, 2274-2286
Resumo
[Abstract]: We report on a macrocyclic platform based on an 18-membered macrocycle that forms kinetically highly
inert paramagnetic complexes and possesses an excellent outlook for the development of bioresponsive
paraCEST (paramagnetic chemical exchange saturation transfer) contrast agents. The investigated europium(
III) chelate is non-hydrated and contains four amide groups, each possessing two paramagnetically
shifted proton resonances distant from bulk water. The X-ray crystal structure and solution studies indicate
that the metal ion is ten-coordinated, being directly bound to the six N atoms of the macrocycle and
the four amide O atoms of the pendant arms. The complex presents an excellent inertness with respect
to dissociation, being stable under a variety of harsh conditions, including highly acidic and basic media or
elevated temperatures. The amide protons are in slow-to-intermediate exchange with bulk water, which
gives rise to the generation of a strong CEST effect at low probe concentration and saturation powers
(∼25% at 5 mM, B1 = 5 μT, 37 °C). We demonstrate the potential of this platform for mapping pH in its
microenvironment and foresee potential for the development of diverse paraCEST probes and sensors.
Versión do editor
Dereitos
Atribución 4.0 España
ISSN
2052-1553