Listar GI-MODES - Artigos por autor "Jácome, M. A."
Mostrando ítems 1-20 de 23
-
A Product-Limit Estimator of the Conditional Survival Function When Cure Status Is Partially Known
Safari, Wende Clarence; López-de-Ullibarri, Ignacio; Jácome, M. A. (Wiley, 2021-03-01)[Abstract] We introduce a nonparametric estimator of the conditional survival function in the mixture cure model for right-censored data when cure status is partially known. The estimator is developed for the setting of a ... -
Altered pathways in methylome and transcriptome longitudinal analysis of normal weight and bariatric surgery women
Nicoletti, C. F.; Pinhel, M.A.S.; Noronha, N.Y.; De Oliveira, B.A.; Salgado Junior, W.; Jácome, M. A.; Díaz-Lagares, Angel; Casanueva, F.; Crujeiras, A. B.; Nonino, C. B. (NLM (Medline), 2020-04-15)[Abstract] DNA methylation could provide a link between environmental, genetic factors and weight control and can modify gene expression pattern. This study aimed to identify genes, which are differentially expressed and ... -
Characterizing the Invasive Tumor Front of Aggressive Uterine Adenocarcinoma and Leiomyosarcoma
Sanegre, Sabina; Eritja, Núria; Andrea, Carlos de; Díaz-Martín, Juan; Díaz-Lagares, Angel; Jácome, M. A.; Salguero Aranda, Carmen; García-Ros, David; Davidson, Ben; López-López, Rafael; Melero, Ignacio; Navarro, Samuel; Ramón y Cajal, Santiago; Alava, Enrique de; Matias-Guiu, Xavier; Noguera, Rosa (Frontiers, 2021)[Abstract] The invasive tumor front (the tumor–host interface) is vitally important in malignant cell progression and metastasis. Tumor cell interactions with resident and infiltrating host cells and with the surrounding ... -
Comparing conditional survival functions with missing population marks in a competing risks model
Bandyopadhyay, Dipankar; Jácome, M. A. (Elsevier, 2016-11-25)[Abstract] In studies involving nonparametric testing of the equality of two or more survival distributions, the survival curves can exhibit a wide variety of behaviors such as proportional hazards, early/late differences, ... -
DNA methylation screening after roux-en Y gastric bypass reveals the epigenetic signature stems from genes related to the surgery per se
Nicoletti, C. F.; Pinhel, M.A.S.; Díaz-Lagares, Angel; Casanueva, F.; Jácome, M. A.; Pinhanelli, Vitor Caressato; De Oliveira, B.A.; Crujeiras, A. B.; Nonino, C. B. (Springer Nature, 2019-05-27)[Abstract] Background/objectives: Obesity has been associated with gene methylation regulation. Recent studies have shown that epigenetic signature plays a role in metabolic homeostasis after Roux-en Y gastric bypass ... -
Epigenetic Landscape in Blood Leukocytes Following Ketosis and Weight Loss Induced by a Very Low Calorie Ketogenic Diet (VLCKD) in Patients With Obesity
Crujeiras, A. B.; Izquierdo, Andrea G.; Primo, David; Milagro, F; Sajoux, Ignacio; Jácome, M. A.; Fernández-Quintela, Alfredo; Portillo, Maria P.; Martínez, J.A.; Martínez Olmos, Miguel Ángel; Luis, Daniel de; Casanueva, F. (Elsevier, 2021)[Abstract] Background:The molecular mechanisms underlying the potential health benefits of a ketogenic diet areunknown and could be mediated by epigenetic mechanisms.Objective:To identify the changes in the obesity-related ... -
Epigenomic Analysis Reveals a Unique DNA Methylation Program of Metastasis-Competent Circulating Tumor Cells in Colorectal Cancer
Bao-Caamano, Aida; Costa-Fraga, Nicolás; Cayrefourcq, Laure; Jácome, M. A.; Rodríguez-Casanova, Aitor; Muinelo Romay, Laura; López-López, Rafael; Alix-Panabières, Catherine; Díaz-Lagares, Ángel (Springer Nature, 2023-09-16)[Abstract] Circulating tumor cells (CTCs) and epigenetic alterations are involved in the development of metastasis from solid tumors, such as colorectal cancer (CRC). The aim of this study was to characterize the DNA ... -
Estimating Lengths-Of-Stay of Hospitalized COVID-19 Patients Using a Non-parametric Model: A Case Study in Galicia (Spain)
López-Cheda, Ana; Cao, Ricardo; De Salazar, Pablo M.; Jácome, M. A. (Cambridge University Press, 2021)[Abstract] Estimating the lengths-of-stay (LoS) of hospitalised COVID-19 patients is key for predicting the hospital beds’ demand and planning mitigation strategies, as overwhelming the healthcare systems has critical ... -
Estimation of patient flow in hospitals using up-to-date data. Application to bed demand prediction during pandemic waves
García-Vicuña, Daniel; López-Cheda, Ana; Jácome, M. A.; Mallor, Fermín (PLOS, 2023-02-27)[Abstract] Hospital bed demand forecast is a first-order concern for public health action to avoid healthcare systems to be overwhelmed. Predictions are usually performed by estimating patients flow, that is, lengths of ... -
Exercise training and DNA methylation profile in post-bariatric women: Results from an exploratory study
Nicoletti, C. F.; Roschel, Hamilton; Merege-Filho, Carlos; Lima, Alisson P.; Gil, Saulo; Pinhel, M.A.S.; Noronha, N.Y.; Santo, Marco Aurelio; Jácome, M. A.; Crujeiras, A. B.; Gualano, Bruno; Nonino, C. B. (Frontiers Media S.A., 2023-02-08)[Abstract]: Exercise training and bariatric surgery have been shown to independently modulate DNA methylation profile in clusters of genes related to metabolic and inflammatory pathways. This study aimed to investigate the ... -
Inter-and Intra-Examiner Reliability of Supraspinatus Muscle Tendon Palpation: A Cross-Sectional Study by Ultrasonography
Naranjo-Cinto, Fermín; Falcón-Machado, Giezi; Garrido-Marín, Alejandro; Senín-Camargo, Francisco; Jácome, M. A.; Fernández-Matías, Rubén; Pecos-Martín, Daniel; Gallego-Izquierdo, Tomás (Kauno Medicinos Universitetas,Kaunas University of Medicine, 2020-02-18)[Abstract] Background and objectives: Palpation is an inherent and basic skill of health professionals—particularly manual therapists who base their diagnosis and treatment in a clinical environment. Many authors have ... -
Latency function estimation under the mixture cure model when the cure status is available
Safari, Wende Clarence; López-de-Ullibarri, Ignacio; Jácome, M. A. (Springer, 2023-03)[Abstract]: This paper addresses the problem of estimating the conditional survival function of the lifetime of the subjects experiencing the event (latency) in themixture curemodel when the cure status information is ... -
Molecular basis of Gender Dysphoria: androgen and estrogen receptor interaction
Fernández, Rosa; Guillamón, Antonio; Cortés-Cortés, Joselyn; Gómez-Gil, Esther; Jácome, M. A.; Esteva, Isabel; Almaraz, Mari Cruz; Mora, Mireia; Aranda, Gloria; Pásaro, Eduardo (Elsevier, 2018-08-27)[Abstract] Background: Polymorphisms in sex steroid receptors have been associated with transsexualism. However, published replication studies have yielded inconsistent findings, possibly because of a limited sample size ... -
New Problems for Old Vineyards: Mitigating the Impacts of Yellow-Legged Hornets (Vespa velutina) in a Historical Wine-Producing Area
Lueje, Yaiza R.; Jácome, M. A.; Servia, María J. (Elsevier, 2024-03-14)[Abstract] Traditional small-sized vineyards are especially sensitive to different impacts, including the arrival of new pests. The adults of the yellow-legged hornet (Vespa velutina), an invasive alien species present in ... -
Nonparametric covariate hypothesis tests for the cure rate in mixture cure models
López-Cheda, Ana; Jácome, M. A.; Keilegom, Ingrid Van; Cao, Ricardo (John Wiley & Sons, 2020-06)[Abstract]: In lifetime data, like cancer studies, there may be long term survivors, which lead to heavy censoring at the end of the follow-up period. Since a standard survival model is not appropriate to handle these data, ... -
Nonparametric Estimation in Mixture Cure Models with Covariates
López-Cheda, Ana; Peng, Yingwei; Jácome, M. A. (Springer Nature, 2023-05-17)[Abstract] Nonparametric estimation methods for the cure rate and the distribution of the failure time of uncured subjects with covariates for censored survival data have attracted much attention in the last few years. To ... -
Nonparametric incidence estimation and bootstrap bandwidth selection in mixture cure models
López-Cheda, Ana; Cao, Ricardo; Jácome, M. A.; Keilegom, Ingrid Van (Elsevier, 2017-01)[Abstract]: A completely nonparametric method for the estimation of mixture cure models is proposed. A nonparametric estimator of the incidence is extensively studied and a nonparametric estimator of the latency is presented. ... -
Nonparametric Kernel Estimation of the Probability of Cure in a Mixture Cure Model when the Cure Status is Partially Observed
Safari, Wende Clarence; López-de-Ullibarri, Ignacio; Jácome, M. A. (Sage, 2022-08-01)[Abstract] Cure models are a class of time-to-event models where a proportion of individuals will never experience the event of interest. The lifetimes of these so-called cured individuals are always censored. It is usually ... -
Nonparametric latency estimation for mixture cure models
López-Cheda, Ana; Jácome, M. A.; Cao, Ricardo (Springer Nature, 2017-06)[Abstract]: A nonparametric latency estimator for mixture cure models is studied in this paper. An i.i.d. representation is obtained, the asymptotic mean squared error of the latency estimator is found, and its asymptotic ... -
npcure: An R Package for Nonparametric Inference in Mixture Cure Models
López-Cheda, Ana; Jácome, M. A.; López-de-Ullibarri, Ignacio (Technische Universitaet Wien, 2021)[Abstract] Mixture cure models have been widely used to analyze survival data with a cure fraction. They assume that a subgroup of the individuals under study will never experience the event (cured subjects). So, the goal ...