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What did we learn from 'omics' studies in osteoarthritis
(Wolters Kluwer, 2018-01-01)
[Abstract] Purpose of review: 'Omics' technologies developed for the massive analysis of the major biologically relevant molecules (genes, proteins, metabolites) have been applied to the study of osteoarthritis (OA) for ...
Mitochondrial haplogroups define two phenotypes of osteoarthritis
(Frontiers, 2012-05-11)
[Abstract] Objective: To assess a mitochondrion-related phenotype in patients with osteoarthritis (OA).
Methods: Serum levels of the following OA-related biomarkers: matrix metalloproteinase-1 (MMP-1); MMP-3; MMP-13; ...
Genetic biomarkers in osteoarthritis: a quick overview
(Faculty Opinions, 2021-11-10)
[Abstract] Osteoarthritis (OA) is a chronic musculoskeletal disease with a polygenic and heterogeneous nature. In addition, when clinical manifestations appear, the evolution of the disease is usually already irreversible. ...
Effect of hydrogen sulfide sources on inflammation and catabolic markers on interleukin 1β-stimulated human articular chondrocytes
(Elsevier, 2014-07)
[Abstract] Objective. Hydrogen sulfide (H2S), the third gasotransmitter together with NO and CO, is emerging as a regulator of inflammation. To test if it might offer therapeutic value in the treatment of osteoarthritis ...
Generation of human immortalized chondrocytes from osteoarthritic and healthy cartilage
(The British Editorial Society of Bone & Joint Surgery, 2023-01-17)
[Abstract] Aims. After a few passages of in vitro culture, primary human articular chondrocytes undergo senescence and loss of their phenotype. Most of the available chondrocyte cell lines have been obtained from cartilage ...
Can gait patterns be explained by joint structure in people with and without radiographic knee osteoarthritis?: data from the IMI-APPROACH cohort
(Springer Nature, 2024-03-27)
[Abstract]
Objective: To determine the association between joint structure and gait in patients with knee osteoarthritis (OA).
Methods: IMI-APPROACH recruited 297 clinical knee OA patients. Gait data was collected ...
Metabolic syndrome is not associated with erosive hand osteoarthritis: a cross-sectional study using data from the PROCOAC cohort
(Springer Nature, 2024-03-12)
[Abstract] To delineate the phenotype of erosive hand osteoarthritis (EHOA) in a Spanish population and assess its correlation with metabolic syndrome. We conducted a cross-sectional study using baseline data from the ...
Defective chaperone-mediated autophagy is a hallmark of joint disease in patients with knee osteoarthritis
(Elsevier, 2023-03-08)
[Abstract] Objective: Defects in autophagy contribute to joint aging and Osteoarthritis (OA). Identifying specific autophagy types could be useful for developing novel treatments for OA.
Design: An autophagy-related ...
Epigenetics as a therapeutic target in osteoarthritis
(MDPI, 2023-01-21)
[Abstract] Osteoarthritis (OA) is a heterogenous, complex disease affecting the integrity of diarthrodial joints that, despite its high prevalence worldwide, lacks effective treatment. In recent years it has been discovered ...
Proteomic profiling of human menisci from mild joint degeneration and end-stage osteoarthritis versus healthy controls
(Elsevier, 2023-12)
[Abstract] Objective. To gain new insight into the molecular changes of the meniscus by comparing the proteome profiles of healthy controls with mild degeneration and end-stage osteoarthritis (OA).
Method. We obtained ...