What did we learn from 'omics' studies in osteoarthritis

Ver/ abrir
Use este enlace para citar
http://hdl.handle.net/2183/26919Coleccións
- Investigación (FCS) [1286]
Metadatos
Mostrar o rexistro completo do ítemTítulo
What did we learn from 'omics' studies in osteoarthritisData
2018-01-01Cita bibliográfica
Ruiz-Romero C, Rego-Pérez I, Blanco FJ. What did we learn from 'omics' studies in osteoarthritis. Curr Opin Rheumatol. 2018;30(1):114-120
Resumo
[Abstract] Purpose of review: 'Omics' technologies developed for the massive analysis of the major biologically relevant molecules (genes, proteins, metabolites) have been applied to the study of osteoarthritis (OA) for more than a decade.
Recent findings: 'Omics' studies have undoubtedly contributed to increase the knowledge on pathogenic processes related with OA and have provided hundreds to thousands of molecules that might have a putative biomarker utility for this disease.
Summary: This review describes the most recent 'omics' studies in OA research, their conclusions, and discuss those remaining challenges. Still many validation studies must be performed in large and well-characterized cohorts for the translation of the findings from 'omics' strategies to clinical applications. The development of tools for the intelligent integration of 'omics' data with clinical and imaging information is also mandatory to take full profit of the work that has been already performed.
Palabras chave
Osteoarthritis
Genomics
Proteomics
Metabolomics
Biomakers
Genomics
Proteomics
Metabolomics
Biomakers
Descrición
Review article
Versión do editor
Dereitos
This is a non-final version of an article published in final form in Current Opinion of Rheumatology.
ISSN
1040-8711