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Host-Guest Stimuli-Responsive Click Chemistry
dc.contributor.author | Blanco-Gómez, Arturo | |
dc.contributor.author | Díaz Abellás, Mauro | |
dc.contributor.author | Montes de Oca Estrada, Iván | |
dc.contributor.author | Peinador, Carlos | |
dc.contributor.author | Pazos, Elena | |
dc.contributor.author | García, Marcos D. | |
dc.date.accessioned | 2024-09-25T07:58:04Z | |
dc.date.available | 2024-09-25T07:58:04Z | |
dc.date.issued | 2024-05-10 | |
dc.identifier.citation | A. Blanco-Gómez, M. Díaz-Abellás, I. Montes de Oca, C. Peinador, E. Pazos, M. D. García, Chem. Eur. J. 2024, 30, e202400743. https://doi.org/10.1002/chem.202400743 | es_ES |
dc.identifier.issn | 1521-3765 | |
dc.identifier.issn | 0947-6539 | |
dc.identifier.uri | http://hdl.handle.net/2183/39209 | |
dc.description | Financiado para publicación en acceso aberto: Universidade da Coruña/CISUG | es_ES |
dc.description.abstract | [Abstract] Click chemistry has reached its maturity as the weapon of choice for the irreversible ligation of molecular fragments, with over 20 years of research resulting in the development or improvement of highly efficient kinetically controlled conjugation reactions. Nevertheless, traditional click reactions can be disadvantageous not only in terms of efficiency (side products, slow kinetics, air/water tolerance, etc.), but also because they completely avoid the possibility to reversibly produce and control bound/unbound states. Recently, non-covalent click chemistry has appeared as a more efficient alternative, in particular by using host-guest self-assembled systems of high thermodynamic stability and kinetic lability. This review discusses the implementation of molecular switches in the development of such non-covalent ligation processes, resulting in what we have termed stimuli-responsive click chemistry, in which the bound/unbound constitutional states of the system can be favored by external stimulation, in particular using host-guest complexes. As we exemplify with handpicked selected examples, these supramolecular systems are well suited for the development of human-controlled molecular conjugation, by coupling thermodynamically regulated processes with appropriate temporally resolved extrinsic control mechanisms, thus mimicking nature and advancing our efforts to develop a more function-oriented chemical synthesis. | es_ES |
dc.description.sponsorship | We are thankful for the funding received from the MCIN/AEI/10.13039/501100011033 and ERDF A way of making Europe (PID2022-137361NB-I00 and PID2022-142374NB-I00), the Consellería de Cultura, Educación e Universidade da Xunta de Galicia (ED431C 2022/39, and 508/2020), and the European Research Council (ERC) under the European Union's Horizon 2020 research and innovation programme (grant agreement no. 851179). M. D.-A. thanks the Ministerio de Universidades for his predoctoral fellowship (FPU21/06302), A. B.-G. thanks the Consellería de Cultura, Educación e Universidade, Xunta de Galicia for his postdoctoral fellowship (ED481B-2021-099), and E. P. thanks the MCIN/AEI/10.13039/501100011033 and ESF Investing in your future for her Ramón y Cajal contract (RYC2019-027199-I). Funding for open access charge: Universidade da Coruña/CISUG | es_ES |
dc.description.sponsorship | Xunta de Galicia; ED431C 2022/39 | es_ES |
dc.description.sponsorship | Xunta de Galicia; 508/2020 | es_ES |
dc.description.sponsorship | Xunta de Galicia; ED481B-2021-099 | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Wiley | es_ES |
dc.relation | info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2022-137361NB-I00/ES/NUEVOS INTERRUPTORES MOLECULARES DE BIPIRIDINIO. HACIA LA FUNCIONALIDAD QUIMICA CONTROLADA EN MEDIO ACUOSO | es_ES |
dc.relation | info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2022-142374NB-I00/ES/SISTEMAS HIBRIDOS PEPTIDO-NANOPARTICULA EN BIOMEDICINA Y CATALISIS | es_ES |
dc.relation | info:eu-repo/grantAgreement/EC/H2020/851179 | es_ES |
dc.relation | info:eu-repo/grantAgreement/MUNI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/FPU21%2F06302/ES | es_ES |
dc.relation | info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RYC2019-027199-I/ES | es_ES |
dc.relation.uri | https://doi.org/10.1002/chem.202400743 | es_ES |
dc.rights | Atribución 3.0 España | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.subject | Click chemistry | es_ES |
dc.subject | Host-guest chemistry | es_ES |
dc.subject | Molecular ligation | es_ES |
dc.subject | Molecular switches | es_ES |
dc.subject | Supramolecular switches | es_ES |
dc.title | Host-Guest Stimuli-Responsive Click Chemistry | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.access | info:eu-repo/semantics/openAccess | es_ES |
UDC.journalTitle | Chemistry—A European Journal | es_ES |
UDC.volume | 30 | es_ES |
UDC.issue | 33 | es_ES |
UDC.startPage | e202400743 | es_ES |
dc.identifier.doi | 10.1002/chem.202400743 |
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