Host-Guest Stimuli-Responsive Click Chemistry
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Host-Guest Stimuli-Responsive Click ChemistryAutor(es)
Data
2024-05-10Cita bibliográfica
A. Blanco-Gómez, M. Díaz-Abellás, I. Montes de Oca, C. Peinador, E. Pazos, M. D. García, Chem. Eur. J. 2024, 30, e202400743. https://doi.org/10.1002/chem.202400743
Resumo
[Abstract] Click chemistry has reached its maturity as the weapon of choice for the irreversible ligation of molecular fragments, with over 20 years of research resulting in the development or improvement of highly efficient kinetically controlled conjugation reactions. Nevertheless, traditional click reactions can be disadvantageous not only in terms of efficiency (side products, slow kinetics, air/water tolerance, etc.), but also because they completely avoid the possibility to reversibly produce and control bound/unbound states. Recently, non-covalent click chemistry has appeared as a more efficient alternative, in particular by using host-guest self-assembled systems of high thermodynamic stability and kinetic lability. This review discusses the implementation of molecular switches in the development of such non-covalent ligation processes, resulting in what we have termed stimuli-responsive click chemistry, in which the bound/unbound constitutional states of the system can be favored by external stimulation, in particular using host-guest complexes. As we exemplify with handpicked selected examples, these supramolecular systems are well suited for the development of human-controlled molecular conjugation, by coupling thermodynamically regulated processes with appropriate temporally resolved extrinsic control mechanisms, thus mimicking nature and advancing our efforts to develop a more function-oriented chemical synthesis.
Palabras chave
Click chemistry
Host-guest chemistry
Molecular ligation
Molecular switches
Supramolecular switches
Host-guest chemistry
Molecular ligation
Molecular switches
Supramolecular switches
Descrición
Financiado para publicación en acceso aberto: Universidade da Coruña/CISUG
Versión do editor
Dereitos
Atribución 3.0 España
ISSN
1521-3765
0947-6539
0947-6539