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Parvimonas micra can translocate from the subgingival sulcus of the human oral cavity to colorectal adenocarcinoma
dc.contributor.author | Ladra, Susana | |
dc.contributor.author | Poza, Margarita | |
dc.contributor.author | Conde-Pérez, Kelly | |
dc.contributor.author | Buetas, Elena | |
dc.contributor.author | Aja-Macaya, Pablo | |
dc.contributor.author | Martin-De Arribas, E. | |
dc.contributor.author | Iglesias Corrás, Iago | |
dc.contributor.author | Trigo-Tasende, Noelia | |
dc.contributor.author | Nasser-Ali, Mohammed | |
dc.contributor.author | Estévez, Lara | |
dc.contributor.author | Rumbo-Feal, Soraya | |
dc.contributor.author | Otero Alén, Begoña | |
dc.contributor.author | Noguera, José Francisco | |
dc.contributor.author | Concha, Ángel | |
dc.contributor.author | Pardiñas López, Simón | |
dc.contributor.author | Carda-Diéguez, Miguel | |
dc.contributor.author | Gómez-Randulfe Rodríguez, Martín Igor | |
dc.contributor.author | Martinez-Lago, Nieves | |
dc.contributor.author | Aparicio, Luis A. | |
dc.contributor.author | Bou, Germán | |
dc.contributor.author | Mira, Alex | |
dc.contributor.author | Vallejo, J.A. | |
dc.date.accessioned | 2024-09-03T15:47:00Z | |
dc.date.available | 2024-09-03T15:47:00Z | |
dc.date.issued | 2023 | |
dc.identifier.citation | Conde-Pérez, K., Buetas, E., Aja-Macaya, P., Martin-De Arribas, E., Iglesias-Corrás, I., Trigo-Tasende, N., Nasser-Ali, M., Estévez, L. S., Rumbo-Feal, S., Otero-Alén, B., Noguera, J. F., Concha, Á., Pardiñas-López, S., Carda-Diéguez, M., Gómez-Randulfe, I., Martínez-Lago, N., Ladra, S., Aparicio, L. A., Bou, G., et al. (2023). Parvimonas micra can translocate from the subgingival sulcus of the human oral cavity to colorectal adenocarcinoma. Molecular Oncology. 18(5). 1143-1173 https://doi.org/10.1002/1878-0261.13506 | es_ES |
dc.identifier.uri | http://hdl.handle.net/2183/38829 | |
dc.description.abstract | [Abstract] Oral and intestinal samples from a cohort of 93 colorectal cancer (CRC) patients and 30 healthy controls (non-CRC) were collected for microbiome analysis. Saliva (28 non-CRC and 94 CRC), feces (30 non-CRC and 97 CRC), subgingival fluid (20 CRC), and tumor tissue samples (20 CRC) were used for 16S metabarcoding and/or RNA sequencing (RNAseq) approaches. A differential analysis of the abundance, performed with the ANCOM-BC package, adjusting the P-values by the Holm-Bonferroni method, revealed that Parvimonas was significantly over-represented in feces from CRC patients (P-value < 0.001) compared to healthy controls. A total of 11 Parvimonas micra isolates were obtained from the oral cavity and adenocarcinoma of CRC patients. Genome analysis identified a pair of isolates from the same patient that shared 99.2% identity, demonstrating that P. micra can translocate from the subgingival cavity to the gut. The data suggest that P. micra could migrate in a synergistic consortium with other periodontal bacteria. Metatranscriptomics confirmed that oral bacteria were more active in tumor than in non-neoplastic tissues. We suggest that P. micra could be considered as a CRC biomarker detected in non-invasive samples such as feces. | es_ES |
dc.description.sponsorship | The present authors want to thank all the cancer patients of the University Hospital of A Coruña for participating in this study, collaborating with us despite their health problems. We warmly want to thank Gema Carro Díaz and Montserrat Ingelmo Sánchez (surgical service nurses of HUAC) for their support during patient's recruitment time and also with sample collection. Moreover, we want to appreciate the valuable assistance received in anaerobic culturing by David Velasco Fernández (microbiologist) and Ana María Fernández Liñares (technician), and in FFPE samples processing by the pathology service technicians: Diego Barco Díaz, Cristina Vázquez Costa and Ana María Mejuto Rial. This work would not be possible without all the professionals of the Microbiology, Surgery, Pathology and Oncology services and Biobank from CHUAC who support this microbiome and cancer research project. This study has been funded by Instituto de Salud Carlos III (ISCIII) through the project PI20/00413 and co-funded by the European Union to MP. The work has been also supported by the project RTI2018-102032-B-I00 from the Spanish Ministry of Science and Innovation to AM and by the CIBER INF ISCIII (CB21/13/00055) to GB and MP. Biobank of University Hospital Complex of A Coruña was supported by Instituto de Salud Carlos III – Fondos FEDER (EU) by grant PT20/00128. K. Conde-Pérez was financially supported with a predoctoral fellowship by the Asociación Española Contra el Cáncer (AECC). E. Buetas is supported by a grant from the Spanish Ministry of Science and Innovation with the reference PRE2019-088126. S. Ladra, E. Martin-De Arribas and Iago Iglesias-Corrás are supported by grants from GAIN (Xunta de Galicia, Spain) with references ED431C 2021/53 and ED431G | es_ES |
dc.description.sponsorship | Xunta de Galicia; ED431C 2021/53 | es_ES |
dc.description.sponsorship | Xunta de Galicia; ED431G | es_ES |
dc.language.iso | eng | es_ES |
dc.relation | info:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/CB21%2F13%2F00055/ES/ | es_ES |
dc.relation | info:eu-repo/grantAgreement/ISCII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PT20%2F00128/ES/Plataformas ISCIII de apoyo a la I+D+I en Biomedicina y Ciencias de la Salud: Plataforma de Biobanco y Organoides | es_ES |
dc.relation | info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PRE2019-088126/ES/EFECTOS LOCALES Y SISTEMICOS DE LA MICROBIOTA ORAL | es_ES |
dc.relation | info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018-102032-B-I00/ES/EFECTOS LOCALES Y SISTEMICOS DE LA MICROBIOTA ORAL | es_ES |
dc.relation | info:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PI20%2F00413/ES/FARMACOMICROBIOMICA Y MEDICINA PERSONALIZADA EN LA TERAPIA DEL CANCER COLORECTAL/ | es_ES |
dc.relation.uri | https://doi.org/10.1002/1878-0261.13506 | es_ES |
dc.rights | Creative Commons Attribution License CC-BY | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.subject | Colorectal cancer | es_ES |
dc.subject | Metabarcoding | es_ES |
dc.subject | Metatranscriptomics | es_ES |
dc.subject | Microbiome | es_ES |
dc.subject | Parvimonas micra | es_ES |
dc.subject | Periodontal disease | es_ES |
dc.title | Parvimonas micra can translocate from the subgingival sulcus of the human oral cavity to colorectal adenocarcinoma | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.access | info:eu-repo/semantics/openAccess | es_ES |
UDC.journalTitle | Molecular Oncology | es_ES |
UDC.volume | 18 | es_ES |
UDC.issue | 5 | es_ES |
UDC.startPage | 114 | es_ES |
UDC.endPage | 1173 | es_ES |
dc.identifier.doi | 10.1002/1878-0261.13506 |
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GI-LBD - Artigos [51]