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Poly(Boc-acryloyl hydrazide): the importance of temperature and RAFT agent degradation on its preparation
dc.contributor.author | Adoni, Pavan | |
dc.contributor.author | Creese, Oliver | |
dc.contributor.author | Su, Guanlong | |
dc.contributor.author | Romanyuk, Andrey | |
dc.contributor.author | Fernández-Trillo, Paco | |
dc.date.accessioned | 2024-07-11T16:50:04Z | |
dc.date.available | 2024-07-11T16:50:04Z | |
dc.date.issued | 2019 | |
dc.identifier.citation | Creese, O., Adoni, P., Su, G., Romanyuk, A., & Fernandez-Trillo, P. (2019). Poly(Boc-acryloyl hydrazide): The importance of temperature and RAFT agent degradation on its preparation. Polymer Chemistry, 10(41), 5645-5651. https://doi.org/10.1039/C9PY01222B | es_ES |
dc.identifier.uri | http://hdl.handle.net/2183/37947 | |
dc.description.abstract | [Abstract] Poly(acryloyl hydrazide) is a versatile polymer scaffold readily functionalised through post-polymerisation modification with aldehydes to yield polymers for biological applications. However, its polymerisation is affected by nucleophilic degradation of the RAFT agent that leads to early termination, an issue often overlooked in the polymerisation of primary acrylamides. Here we report the effect of temperature on the RAFT polymerisation of N′-(tert-butoxycarbonyl)acryloyl hydrazide (1) and demonstrate that by carefully selecting this polymerisation temperature, a balance between rate of polymerisation and rate of degradation of the RAFT agent can be achieved. This way greater control over the polymerisation process is achieved, allowing the synthesis of Boc-protected poly(acryloyl hydrazide) with higher degrees of polymerisation (DP) than those obtained previously, while still maintaining low dispersities (ĐM). | es_ES |
dc.description.sponsorship | All authors thank the P. F. T. group for useful discussions. P. F. T. thanks the University of Birmingham for the John Evans Fellowship. O. C. and P. A. thank BBSRC’s Midlands Integrative Biosciences Training Partnership MIBTP (BB/ M01116X/1) for PhD scholarships and A. R. thanks the European Union’s Horizon 2020 Research and Innovation Programme (Marie Sklodowska-Curie Grant Agreement No. 795082). | es_ES |
dc.description.sponsorship | United Kindong. Midlands Integrative Biosciences Training Partnership; MIBTP (BB/ M01116X/1 | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Royal Society of Chemistry | es_ES |
dc.relation | info:eu-repo/grantAgreement/EC/H2020/795082 | es_ES |
dc.relation.uri | https://doi.org/10.1039/C9PY01222B | es_ES |
dc.rights | Creative Commons Attribution 3.0 Unported Licence | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.subject | Poly(Boc-acryloyl hydrazide) | es_ES |
dc.subject | RAFT | es_ES |
dc.subject | Polymerization | es_ES |
dc.title | Poly(Boc-acryloyl hydrazide): the importance of temperature and RAFT agent degradation on its preparation | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.access | info:eu-repo/semantics/openAccess | es_ES |
UDC.journalTitle | Polymer Chemistry | es_ES |
UDC.volume | 10 | es_ES |
UDC.issue | 41 | es_ES |
UDC.startPage | 5645 | es_ES |
UDC.endPage | 5651 | es_ES |
dc.identifier.doi | 10.1039/C9PY01222B |
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