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Graphene, Other Carbon Nanomaterials and the Immune System: Toward Nanoimmunity-By-Design
dc.contributor.author | Gazzi, Arianna | |
dc.contributor.author | Criado, Alejandro | |
dc.contributor.author | Delogu, Lucia Gemma | |
dc.date.accessioned | 2024-06-26T15:33:07Z | |
dc.date.available | 2024-06-26T15:33:07Z | |
dc.date.issued | 2020-07-13 | |
dc.identifier.citation | Arianna Gazzi et al 2020 J. Phys. Mater. 3 034009 DOI 10.1088/2515-7639/ab9317 | es_ES |
dc.identifier.issn | 2515-7639 | |
dc.identifier.uri | http://hdl.handle.net/2183/37432 | |
dc.description | © 2020 The Author(s). Published by IOP Publishing Ltd. Original content from this work may be used under the terms of the Creative Commons Attribution 4.0 license (http://creativecommons.org/licenses/by/4.0/). Any further distribution of this work must maintain attribution to the author(s) and the title of the work, journal citation and DOI. | es_ES |
dc.description.abstract | [Abstract]: Carbon-based materials (CBMs), such as graphene, nanodiamonds, carbon fibers, and carbon dots, have attracted a great deal scientific attention due to their potential as biomedical tools. Following exposure, particularly intravenous injection, these nanomaterials can be recognized by immune cells. Such interactions could be modulated by the different physicochemical properties of the materials (e.g. structure, size, and chemical functions), by either stimulating or suppressing the immune response. However, a harmonized cutting-edge approach for the classification of these materials based not only on their physicochemical parameters but also their immune properties has been missing. The European Commission-funded G-IMMUNOMICS and CARBO-IMmap projects aimed to fill this gap, developing a functional pipeline for the qualitative and quantitative immune characterization of graphene, graphene-related materials (GRMs), and other CBMs. The goal was to open breakthrough perspectives for the definition of the immune profiles of these materials. Here, we summarize our methodological approach, key results, and the necessary multidisciplinary expertise ranging across various fields, from material chemistry to engineering, immunology, toxicology, and systems biology. G-IMMUNOMICS, as a partnering project of the Graphene Flagship, the largest scientific research initiative on graphene worldwide, also complemented the studies performed in the Flagship on health and environmental impact of GRMs. Finally, we present the nanoimmunity-by-design concept, developed within the projects, which can be readily applied to other 2D materials. Overall, the G-IMMUNOMICS and CARBO-IMmap projects have provided new insights on the immune impact of GRMs and CBMs, thus laying the foundation for their safe use and future translation in medicine. | es_ES |
dc.description.sponsorship | We gratefully acknowledge financial support from FLAG-ERA JTC Graphene 2015 (G-IMMUNOMICS project), awarded to L G D, A B, M P, A Y, K K, and B S; and Euro-pean Union's Horizon 2020 research and innovation programme under the Marie Sklo-dowska-Curie Grant Agreement No. 734381 (CARBO-IMmap), awarded to L G D, A B, M P, D B, X F, Y M, C C, G C, and M P. The work in San Sebastián was performed under the Maria de Maeztu Units of Excellence Program from the Spanish State Re-search Agency – Grant No. MDM-2017-0720. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | IOP Publishing | es_ES |
dc.relation | info:eu-repo/grantAgreement/EC/H2020/730027 | es_ES |
dc.relation | info:eu-repo/grantAgreement/EC/H2020/734381 | es_ES |
dc.relation | info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/MDM-2017-0720/ES/ | es_ES |
dc.relation.uri | https://doi.org/10.1088/2515-7639/ab9317 | es_ES |
dc.subject | Graphene | es_ES |
dc.subject | Carbon nanotubes | es_ES |
dc.subject | Nanomedicine | es_ES |
dc.subject | Nanosafety | es_ES |
dc.subject | Nanotoxicology | es_ES |
dc.subject | Single cell mass cytometry | es_ES |
dc.subject | Systems biology | es_ES |
dc.title | Graphene, Other Carbon Nanomaterials and the Immune System: Toward Nanoimmunity-By-Design | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.access | info:eu-repo/semantics/openAccess | es_ES |
UDC.journalTitle | Journal of Physics: Materials | es_ES |
UDC.volume | 3 | es_ES |
UDC.issue | 3 | es_ES |
UDC.startPage | Article 034009 | es_ES |
dc.identifier.doi | 10.1088/2515-7639/ab9317 |
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