Skip navigation
  •  Inicio
  • UDC 
    • Cómo depositar
    • Políticas do RUC
    • FAQ
    • Dereitos de Autor
    • Máis información en INFOguías UDC
  • Percorrer 
    • Comunidades
    • Buscar por:
    • Data de publicación
    • Autor
    • Título
    • Materia
  • Axuda
    • español
    • Gallegan
    • English
  • Acceder
  •  Galego 
    • Español
    • Galego
    • English
  
Ver ítem 
  •   RUC
  • Facultade de Ciencias da Saúde
  • Investigación (FCS)
  • Ver ítem
  •   RUC
  • Facultade de Ciencias da Saúde
  • Investigación (FCS)
  • Ver ítem
JavaScript is disabled for your browser. Some features of this site may not work without it.

Toxoplasma gondii IgG serointensity is positively associated with frailty

Thumbnail
Ver/abrir
Mohyuddin_Toxoplasma_2023.pdf (386.8Kb)
Use este enlace para citar
http://hdl.handle.net/2183/35008
Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC-BY-NC-ND 4.0)
A non ser que se indique outra cousa, a licenza do ítem descríbese como Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC-BY-NC-ND 4.0)
Coleccións
  • Investigación (FCS) [1295]
Metadatos
Mostrar o rexistro completo do ítem
Título
Toxoplasma gondii IgG serointensity is positively associated with frailty
Autor(es)
Mohyuddin, Hira
Laffon, Blanca
Teixeira, Joao
Costa, Solange
Teixeira Gomes, Armanda
Pásaro, Eduardo
Constantine, Niel
Dagdag, Aline
Ortmeyer, Heidi K.
Tizenberg, Boris
Afram, Liubov
Yen, Poyu
Marano, Christopher
Lowry, Christopher A.
Hoisington, Andrew J.
RachBeisel, Jill A.
Valdiglesias, Vanessa
Lema Arranz, Carlota
Fernández-Bertólez, Natalia
Maseda, Ana
Millán-Calenti, José Carlos
Kovacs, Elizabeth J.
Gostner, Johanna
Fuchs, Dietmar
Brenner, Lisa A.
Lorenzo-López, Laura
Postolache, Teodor T.
Data
2023-11-06
Cita bibliográfica
Mohyuddin H, Laffon B, Teixeira JP, Costa S, Teixeira-Gomes A, Pásaro E, Constantine N, Dagdag A, Ortmeyer HK, Tizenberg B, Afram L, Yen P, Marano C, Lowry CA, Hoisington AJ, RachBeisel JA, Valdiglesias V, Lema-Arranz C, Fernández-Bertólez N, Maseda A, Millán-Calenti JC, Kovacs EJ, Gostner JM, Fuchs D, Brenner LA, Lorenzo-López L, Postolache TT. Toxoplasma gondii IgG Serointensity Is Positively Associated With Frailty. J Gerontol A Biol Sci Med Sci. 2024 Mar 1;79(3):glad228.
Resumo
[Abstract] Background: Persistent inflammation related to aging ("inflammaging") is exacerbated by chronic infections and contributes to frailty in older adults. We hypothesized associations between Toxoplasma gondii (T. gondii), a common parasite causing an oligosymptomatic unremitting infection, and frailty, and secondarily between T. gondii and previously reported markers of immune activation in frailty. Methods: We analyzed available demographic, social, and clinical data in Spanish and Portuguese older adults [N = 601; age: mean (SD) 77.3 (8.0); 61% women]. Plasma T. gondii immunoglobulin G (IgG) serointensity was measured with an enzyme-linked immunosorbent assay. The Fried criteria were used to define frailty status. Validated translations of Mini-Mental State Examination, Geriatric Depression Scale, and the Charlson Comorbidity Index were used to evaluate confounders. Previously analyzed biomarkers that were significantly associated with frailty in both prior reports and the current study, and also related to T. gondii serointensity, were further accounted for in multivariable logistic models with frailty as outcome. Results: In T. gondii-seropositives, there was a significant positive association between T. gondii IgG serointensity and frailty, accounting for age (p = .0002), and resisting adjustment for multiple successive confounders. Among biomarkers linked with frailty, kynurenine/tryptophan and soluble tumor necrosis factor receptor II were positively associated with T. gondii serointensity in seropositives (p < .05). Associations with other biomarkers were not significant. Conclusions: This first reported association between T. gondii and frailty is limited by a cross-sectional design and warrants replication. While certain biomarkers of inflammaging were associated with both T. gondii IgG serointensity and frailty, they did not fully mediate the T. gondii-frailty association.
Palabras chave
Chronic toxoplasmosis
Inflamagging
Kynurenine to tryptophan ratio
sTNF-RII
 
Versión do editor
https://doi.org/10.1093/gerona/glad228
Dereitos
Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC-BY-NC-ND 4.0)
ISSN
1079-5006

Listar

Todo RUCComunidades e colecciónsPor data de publicaciónAutoresTítulosMateriasGrupo de InvestigaciónTitulaciónEsta colecciónPor data de publicaciónAutoresTítulosMateriasGrupo de InvestigaciónTitulación

A miña conta

AccederRexistro

Estatísticas

Ver Estatísticas de uso
Sherpa
OpenArchives
OAIster
Scholar Google
UNIVERSIDADE DA CORUÑA. Servizo de Biblioteca.    DSpace Software Copyright © 2002-2013 Duraspace - Suxestións