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Association of torquetenovirus viremia with physical frailty and cognitive impairment in three independent european cohorts
dc.contributor.author | Giacconi, Robertina | |
dc.contributor.author | Laffon, Blanca | |
dc.contributor.author | Costa, Solange | |
dc.contributor.author | Teixeira-Gomes, Armanda | |
dc.contributor.author | Maggi, Fabrizio | |
dc.contributor.author | Macera, Lisa | |
dc.contributor.author | Spezia, Pietro Giogio | |
dc.contributor.author | Piacenza, Francesco | |
dc.contributor.author | Bürkle, Alexander | |
dc.contributor.author | Moreno-Villanueva, María | |
dc.contributor.author | Bonassi, Stefano | |
dc.contributor.author | Valdiglesias, Vanessa | |
dc.contributor.author | Teixeira, Joao Paulo | |
dc.contributor.author | Dollé, Martijn E.T. | |
dc.contributor.author | Rietman, M. Liset | |
dc.contributor.author | Jansen, Eugène | |
dc.contributor.author | Grune, Tilman | |
dc.contributor.author | Gonos, Efstathios S. | |
dc.contributor.author | Franchesci, Claudio | |
dc.contributor.author | Capri, Miriam | |
dc.contributor.author | Weinberger, Birgit | |
dc.contributor.author | Sikora, Ewa | |
dc.contributor.author | Stuetz, Wolfgang | |
dc.contributor.author | Toussaint, Olivier | |
dc.contributor.author | Debacq-Chainiaux, Florence | |
dc.contributor.author | Hervonen, Antti | |
dc.contributor.author | Hurme, Mikko | |
dc.contributor.author | Slagboom, P. Eline | |
dc.contributor.author | Schön, Christiane | |
dc.contributor.author | Bernhardt, Jürgen | |
dc.contributor.author | Breusing, Nicolle | |
dc.contributor.author | Pásaro, Eduardo | |
dc.contributor.author | Maseda, Ana | |
dc.contributor.author | Lorenzo-López, Laura | |
dc.contributor.author | Millán-Calenti, José Carlos | |
dc.contributor.author | Provinciali, Mauro | |
dc.contributor.author | Malavolta, Marco | |
dc.date.accessioned | 2023-07-10T09:56:09Z | |
dc.date.issued | 2023-01-10 | |
dc.identifier.citation | Giacconi R, Laffon B, Costa S, Teixeira-Gomes A, Maggi F, Macera L, et al. Association of torquetenovirus viremia with physical frailty and cognitive impairment in three independent european cohorts. Gerontology. 2023;69(6):684-693. | es_ES |
dc.identifier.issn | 0304-324X | |
dc.identifier.uri | http://hdl.handle.net/2183/33304 | |
dc.description.abstract | [Abstract] Introduction: Immunosenescence and inflammaging have been implicated in the pathophysiology of frailty. Torquetenovirus (TTV), a single-stranded DNA anellovirus, the major component of the human blood virome, shows an increased replication rate with advancing age. An elevated TTV viremia has been associated with an impaired immune function and an increased risk of mortality in the older population. The objective of this study was to analyze the relation between TTV viremia, physical frailty, and cognitive impairment. Methods: TTV viremia was measured in 1,131 nonfrail, 45 physically frail, and 113 cognitively impaired older adults recruited in the MARK-AGE study (overall mean age 64.7 ± 5.9 years), and then the results were checked in two other independent cohorts from Spain and Portugal, including 126 frail, 252 prefrail, and 141 nonfrail individuals (overall mean age: 77.5 ± 8.3 years). Results: TTV viremia ≥4log was associated with physical frailty (OR: 4.69; 95% CI: 2.06-10.67, p < 0.0001) and cognitive impairment (OR: 3.49, 95% CI: 2.14-5.69, p < 0.0001) in the MARK-AGE population. The association between TTV DNA load and frailty status was confirmed in the Spanish cohort, while a slight association with cognitive impairment was observed (OR: 1.33; 95% CI: 1.000-1.773), only in the unadjusted model. No association between TTV load and frailty or cognitive impairment was found in the Portuguese sample, although a negative association between TTV viremia and MMSE score was observed in Spanish and Portuguese females. Conclusions: These findings demonstrate an association between TTV viremia and physical frailty, while the association with cognitive impairment was observed only in the younger population from the MARK-AGE study. Further research is necessary to clarify TTV's clinical relevance in the onset and progression of frailty and cognitive decline in older individuals. | es_ES |
dc.description.sponsorship | This work was supported by the European Commission (Project Full Name: European Study to Establish Biomarkers of Human Ageing; Project Acronym: MARK-AGE; Project No. 200880) and in part by the Project: SInergie di RIcerca della Rete Aging (SIRI) by Italian Health Ministry. Support was also obtained from the Spanish Ministry of Science and Innovation: MCIN/ AEI/10.13039/501100011033 (Grant PID2020- 113788RB-I00), Xunta de Galicia (ED431B 2022/16, ED431F 2017/09), the Ministry of Education, Culture and Sport (BEAGAL18/00142 to V.V.), and the Spanish Ministry of Economy and Competitiveness, co-financed by the European Social Fund (RYC-2015- 18394 to L.L-L). Armanda Gomes is supported by Fundação para a Ciência e Tecnologia (FCT-MCTES), and the European Social Fund, through Programa Operacional Capital Humano (POCH), under the Grant SFRH/BD/121802/2016. | es_ES |
dc.description.sponsorship | Xunta de Galicia; ED431B 2022/16 | es_ES |
dc.description.sponsorship | Xunta de Galicia; ED431F 2017/09 | es_ES |
dc.description.sponsorship | info:eu-repo/grantAgreement/AEI/Programa Estatal de I+D+i Orientada a los Retos de la Sociedad/PID2020-113788RB-I00/ES/IDENTIFICACION DE FACTORES DE RIESGO Y BIOMARCADORES DE VULNERABILIDAD AL DETERIORO COGNITIVO Y FISICO EN EL ENVEJECIMIENTO | |
dc.description.sponsorship | info:eu-repo/grantAgreement/MINECO/Programa Estatal de Promoción del Talento y su Empleabilidad/RYC-2015-18394/ES/ | |
dc.language.iso | eng | es_ES |
dc.publisher | Karger | es_ES |
dc.relation | eu-repo/grantAgreement/EC/FP7/200880 | |
dc.relation.uri | https://doi.org/10.1159/000528169 | es_ES |
dc.subject | Aging | es_ES |
dc.subject | Cognitive impairment | es_ES |
dc.subject | Inflammation | es_ES |
dc.subject | Physical frailty | es_ES |
dc.subject | Torquetenovirus | es_ES |
dc.title | Association of torquetenovirus viremia with physical frailty and cognitive impairment in three independent european cohorts | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.access | info:eu-repo/semantics/embargoedAccess | es_ES |
dc.date.embargoEndDate | 2024-01-10 | es_ES |
dc.date.embargoLift | 2024-01-10 | |
UDC.journalTitle | Gerontology | es_ES |
UDC.volume | 69 | es_ES |
UDC.issue | 6 | es_ES |
UDC.startPage | 684 | es_ES |
UDC.endPage | 693 | es_ES |
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